Screening antiacne potency of Indonesian medicinal plants: antibacterial, lipase inhibition, and antioxidant activities

Batubara, Irmanida; Mitsunaga, Tohru; Ohashi, Haruo

doi:10.1007/s10086-008-1021-1

Cited by 93 publications

(83 citation statements)

References 15 publications

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“…The anti-P. acnes activity of CSE was markedly stronger than that previously reported by Batubara et al (2009). This may be due to the different solvents used for the extraction as well as the quality of the plant raw materials.…”

Section: Resultsmentioning

confidence: 52%

“…This result agrees with the findings of Xu and Lee (2004) and Batubara et al (2010) who have identified brazilin as the major antibacterial constituent of C. sappan heartwood. However, the previous reports by Batubara et al (2009Batubara et al ( , 2010 indicated that brazilin possessed lower anti-P. acnes than the crude ethanol extract of C. sappan wood. In contrast, our study has confirmed that brazilin was the major antibacterial constituent of C. sappan heartwood, which showed a higher anti-P. acnes activity than CSE as well as itself in the previous report by Batubara et al (2010).…”

Section: Resultsmentioning

confidence: 78%

“…In Thailand, the heartwood has been used as a coloring agent in food, beverages, cosmetics, and garments. It has been reported that C. sappan wood extract also exhibited better antibacterial activity against P. acnes as compared with other 39 medicinal plants from Indonesia (Batubara et al, 2009). Brazilin has been reported to be the active compound against P. acnes (Batubara et al, 2010), but the MIC and MBC values (0.50 mg/mL) were too high to be the antibacterial active principle.…”

Section: Introductionmentioning

confidence: 97%

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Anti-Propionibacterium acnesassay-guided purification of brazilin and preparation of brazilin rich extract fromCaesalpinia sappanheartwood

Nirmal¹,

Panichayupakaranant

2014

Pharmaceutical Biology

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Context: Caesalpinia sappan L. (Leguminosae or Fabaceae) heartwood has been used as a coloring agent, with antibacterial activity in food, beverages, cosmetics, and garments. Objectives: To purify brazilin from C. sappan heartwood and use it as a standard marker for the preparation and standardization of an active constituent-rich extract. Material and methods: Crude ethanol extracts of C. sappan heartwood (CSE) were fractionated to isolate brazilin by an anti-P. acnes assay-guided isolation. Quantitative analysis was performed by HPLC. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) were determined by the broth microdilution method. Results and discussion: Brazilin isolated from CSE possessed antibacterial activity against P. acnes with MIC and MBC values of 15.6 and 31.2 mg/mL, respectively. Brazilin was, therefore, used as a standard marker for standardization and preparation of a brazilin rich extract (BRE). BRE was prepared from CSE using a simple one-step purification using a macroporous resin column eluted with 35% v/v ethanol. This method increased the brazilin content in the BRE up to 39.9% w/w. The antibacterial activity of the standardized BRE against acne involved bacteria was higher than for the CSE but lower than brazilin. However, for industrial applications, a large-scale one-step preparation of BRE has more advantages than the use of pure brazilin in terms of convenience and a low-cost production process. Therefore, BRE is considered as a potential coloring agent with antibacterial activity which is used for pharmaceutical, cosmetic, and nutraceutical applications.

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Section: Resultsmentioning

confidence: 52%

Section: Resultsmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 97%

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Anti-Propionibacterium acnesassay-guided purification of brazilin and preparation of brazilin rich extract fromCaesalpinia sappanheartwood

Nirmal¹,

Panichayupakaranant

2014

Pharmaceutical Biology

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“…In addition, MIC and MBC of all extract was done and none of them was reported previously (Table 4), and the MIC and MBC order were C. pallida>V. pinnata>L. amoena>P. corymbosa respectively. Related to MIC and MBC several medicinal plants of India (Patil et al 2012), Korea (Kim et al 2008b), and Indonesia (Batubara et al 2009) were reported to have MIC and MBC potential against P. acnes. The inhibition of leaf extract from C. pallida may cause by some compounds contained in this plant such as pyrrolizidine alkaloids (Martins et al 2015), peptides (Pelegrini et al 2009), flavonoids (Ko et al 2004) or others compound.…”

Section: Propionibacterium Acnes Inhibitorymentioning

confidence: 99%

The conservation of native, lowland Indonesian Begonia species (Begoniaceae) in Bogor Botanic Gardens

Siregar¹

2017

Biodiversitas

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Abstract.Arung ET, Pasedan WF, Kusuma IW, Hendra M, Supriadi MB. 2017 Four plants were selected for evaluating its property on anti-acne, namely Crotalaria pallida, Lepisanthes amoena, Premna corymbosa, and Vitex pinnata by well diffusion and dilution methods. The zone inhibition (mm) against Propionibacterium acnes of these leaves extract on anti-acne at 1000 μg/mL was 9.33; 16.44; 13.78; 11.00 mm, respectively and chlorampenicol (positive control) was 29.44 mm at 500 μg/mL. These results were in line with traditional used by Dayak tribes in East and North Kalimantan, Indonesia.

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“…These are Andrographis paniculata, Psidium guajava, and Terminalia catappa. The other promising antibacterial plant species are Caesapinia sappan (Xu and Lee, 2004), which has been specifically reported as anti-P. acnes, and Curcuma xanthorrhiza, Goniothalamus macrophyllus, Helminthostachys zeylanica, and Hibiscus tiliaceus (Batubara et al, 2009). In addition, Gynura pseudochina, Koompassia malaccensis, Lepisanthes amoena, Piper cf.…”

Section: Use Of Indonesian Medicinal Plants In Antibacterial Therapiesmentioning

confidence: 99%

Use of Indonesian Medicinal Plants Products Against Acne

Batubara

Mitsunaga

2013

RAS

Self Cite

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Indonesia contains a diverse range of cultures and plants. For a long time, Jamu, which is a traditional Indonesian medicine, had been used for beauty and human health in Indonesia. In this study, Indonesian medicinal plants used for skin care were examined, and the relevant information was update to incorporate anti-acne therapies. The anti-acne mechanisms included antibacterial activity against Propionibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus, bacterial lipase inhibition, antioxidant, and anti-inflammatory activities. Most of the Indonesian medicinal plants used in skin care showed anti-acne activity that utilized et least 2 of these mechanisms. The compounds isolated from the Indonesian traditional medicinal plants related to the anti-acne activities are also discussed. In conclusion, more research on Indonesian medicinal plants is needed.

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Screening antiacne potency of Indonesian medicinal plants: antibacterial, lipase inhibition, and antioxidant activities

Cited by 93 publications

References 15 publications

Anti-Propionibacterium acnesassay-guided purification of brazilin and preparation of brazilin rich extract fromCaesalpinia sappanheartwood

Anti-Propionibacterium acnesassay-guided purification of brazilin and preparation of brazilin rich extract fromCaesalpinia sappanheartwood

The conservation of native, lowland Indonesian Begonia species (Begoniaceae) in Bogor Botanic Gardens

Use of Indonesian Medicinal Plants Products Against Acne

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