Use of Indonesian Medicinal Plants Products Against Acne

Batubara, Irmanida; Mitsunaga, Tohru

doi:10.7831/ras.1.11

Cited by 7 publications

(3 citation statements)

References 33 publications

(29 reference statements)

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“…Several plants have been identified to contain anti-aging substances and these substances were also directly linked with antioxidants. For instance, X. granatum bark extract was reported to reduce acne at DPPH IC 50 24 ppm and was considered as a potential anti-aging and skin cosmetics agent 44 , 45 . FC found in the X. granatum leaves ethyl acetate extracts could promote lifespan increase for normal cells by attacking ROS while also regulating pathways for several growth hormones such as IGF and VEGF 42 .…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug

Darmadi

Batubara

Himawan

et al. 2021

Sci Rep

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Local Xylocarpus granatum leaves were extracted by ethyl acetate solvent and characterized by TLC fingerprinting and 2D 1H NMR spectroscopy to contain phenolic compounds as well as several organic and amino acids as metabolic byproducts, such as succinic acid and acetic acid. Traces of flavonoids and other non-categorized phenolic compounds exhibited intermediate antioxidant activity (antioxidant IC50 84.93 ppm) as well as anticancer activity against HeLa, T47D, and HT-29 cell lines; which the latter being most effective against HT-29 with Fraction 5 contained the strongest activity (anticancer IC50 23.12 ppm). Extracts also behaved as a natural growth factor and nonlethal towards brine shrimps as well as human adipose-derived stem cell hADSC due to antioxidative properties. A stability test was performed to examine how storage conditions factored in bioactivity and phytochemical structure. Extracts were compared with several studies about X. granatum leaves extracts to evaluate how ethnogeography and ecosystem factored on biologically active compounds. Further research on anticancer or antioxidant mechanism on cancer cells is needed to determine whether the extract is suitable as a candidate for an anticancer drug.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug

Darmadi

Batubara

Himawan

et al. 2021

Sci Rep

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“…About 300 distinct native ethnicities live in Indonesia and each ethnic group has used their traditional knowledge to develop medicines based on the availability of materials in their own locality. The geographic variability across Indonesia dictates that different plant species are utilized to cure various diseases by different ethnic communities in different regions of the country (Batubara and Mitsunaga 2013). Alstonia scholaris is generally used as a cure for malaria by various ethnic groups in Indonesia.…”

Section: Medicinal Plantsmentioning

confidence: 99%

Indonesian shrimp resource accounting for sustainable stock management

Anna

2017

Biodiversitas

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Abstract. Hidayat S. 2017. The use by local communities of plants from Sesaot Protected Forest, West Nusa Tenggara,. Sesaot Protected Forest is a forest area located very close to human settlements in Sesaot Village, Narmada Sub-district, West Lombok District, West Nusa Tenggara, Indonesia. The level of dependence of rural communities on the forest resources is very high. This study aimed to determine the range of utilization of plants made by people living around the forests, and to evaluate conservation needs for these plants. Utilization of the various plants by Sesaot society was observed in an ethnobotanical study employing a combination of open interview techniques and field observation over a two week period. The results of the study showed that there were 61 species of forest plants utilized by the Sesaot people. Among the 61 species, there were species that had a single function or others that had multiple functions. There were 20 species utilized as food and beverage; 19 used as medicines and herbs; and 15 species as building materials. Other species were utilized in a variety of ways: as fuel wood, as material for craft and/or furniture, for animal traps, as food wrappings and as ornamental plants. The part of the plant most widely used was wood (30.8%), either as a building material, as craft material, for firewood, or in medical treatments. The utilization of wood products poses significant risks for the survival of certain tree species, because the timber is generally obtained by illegal logging. It was noted that certain prized timber producing species tend to be targeted by illegal loggers; such as garu (Dysoxylum parasiticum), bajur (Pterospermum javanicum), rajumas (Duabanga moluccana) and some species of Myrtaceae. This study showed that Sesaot Protected Forest has an important role in sustaining the daily life of the surrounding community. However, without strong conservation efforts in the management of Sesaot Protected Forest, it is feared that unsustainable utilization practices will lead to the loss of some important plant species from this region.

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“…Sappan wood or Kayu secang (Indonesian) is reported of having medicinal properties, such as natural antioxidant, relieve vomiting of blood, and mix of ingredients for malaria drugs [4]. Indonesian people have used a lot of secang wood as traditional medicine [5]. Secang wood contains gallic acid, tannin, resin, resorcin, brazilin, brazilein, d-alpha-phellandrene, ocimene, essential oil [6].…”

Section: Introductionmentioning

confidence: 99%

A Formulation of Orally Disintegrating Secang (Caesalpinia Sappan L.) Tablets as an Antioxidant With Hydroxypropyl Cellulose as a Masking Agent

Mustarichie

Priambodo

2019

Int J App Pharm

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Objective: The objective of this research was to formulate Orally Disintegrating Tablets (ODT) preparations for secang (Caesalpinia sappan L.) wood extract as antioxidants that met the requirements as a pharmaceutical preparation. Methods: Three ODT formulas were made using the composition of the extract of secang wood, HPC-H, kollidon® CL, Avicel® PH 101, mannitol, acesulfame, magnesium stearate, citric acid, and menthol. The bitter taste of the extract of wood secang was covered with the Hydroxy Propyl Cellulose High Substitution (HPC-H) masking agent. Variations in HPC-H concentration were 4%, 4.5%, and 5%. The evaluation of tablet print mass tested included water content, flow velocity, and resting angle, real density, incompressible density, and compressibility. Evaluation of tablets tested included weight uniformity, uniformity of size, hardness, friability, and disintegration time. The tablet antioxidant activity testing was carried out by the Diphenylpicylhydrazyl (DPPH) method. Results: The results showed that all ODT formulas of secang wood extract were fulfilling the requirements as a tablet preparation according to Indonesian Pharmacopoeia IV. IC50 values obtained from antioxidant testing on the three ODT formulas for a secang wood extract for formula I was 3.614 ppm, formula II was 3.464 ppm, formula III was 3.173 ppm, and the wood extract was 3.757 ppm. Conclusion: The results obtained in this research work clearly indicated ODT formulas of secang wood extract fulfilled Indonesian Pharmacopea IV requirement and belong to the category of very strong antioxidants because they have an IC50 value of less than 50 ppm.

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Use of Indonesian Medicinal Plants Products Against Acne

Cited by 7 publications

References 33 publications

Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug

Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug

Indonesian shrimp resource accounting for sustainable stock management

A Formulation of Orally Disintegrating Secang (Caesalpinia Sappan L.) Tablets as an Antioxidant With Hydroxypropyl Cellulose as a Masking Agent

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