Screening and manifestations of seropositive dengue fever patients in Perambalur: A Hospital based study

Anuradha, M.; Dandekar, Rahul Hanumant

doi:10.5455/ijmsph.2014.040420145

Cited by 8 publications

(7 citation statements)

References 8 publications

(7 reference statements)

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“…We can see from table 2, the value of mean MPV increases as the platelets count increases. This is in accordance with the study conducted by Bashir, et al, 2015, Anuradha, et al, 2014, Navya, et al, 2016and Mukker, et al, 2018 They also observed low value of mean platelet volume (MPV) with low platelet count. Navya, et al,2016 in their study group of 100 patients, saw a mean MPV of <9 fl in 72% of patients.…”

Section: Discussionsupporting

confidence: 91%

Study of platelet indices in dengue fever with thrombocytopenia and correlation of immature platelet fraction (IPF) with platelet recovery

Wayez¹,

Zafar²,

Aijaz³

et al. 2020

Arch Hematol Case Rep Rev

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Recently, novel platelet indices such as Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), and Platelet to Large Cell Ratio (PLCR) have been investigated as prospective platelet activation markers [4]. Mean Platelet Volume is a surrogate marker of bone marrow activity; a high MPV indicates increased megakaryocyte activity. A low MPV indicates marrow suppression. Platelets with increased number and size of pseudopodia differ in size, possibly affecting platelet distribution width (PDW) which increases during platelet activation [4]. Platelet to Large Cell Ratio (PLCR) is signifi cantly decreased in patients with thrombocytosis than in normal while it is increased in thrombocytopenia. PLCR was inversely related to platelet count and directly related to PDW and MPV [5]. The immature platelet fraction (IPF) is a new parameter which is an automated measure of reticulated platelets in peripheral

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Section: Discussionsupporting

confidence: 91%

Study of platelet indices in dengue fever with thrombocytopenia and correlation of immature platelet fraction (IPF) with platelet recovery

Wayez¹,

Zafar²,

Aijaz³

et al. 2020

Arch Hematol Case Rep Rev

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“…Study by Anuradha M et al showed 89% cases with thrombocytopenia which was slightly more than the present study (77.33%). [11,12,13] In the study conducted by Manoharan A et al, MPV was found to be high in patients with bleeding manifestations which similar to the present study. Afsar N et al found a statistically significant p value in their study of MPV which was concurrent with our study.…”

Section: Discussionsupporting

confidence: 90%

Assessment of Platelet Indices as Prognostic Markers in Seropositive Cases of Dengue

S¹

2019

jmscr

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Background: Dengue fever is the most prevalent arboviral disease globally and an increasing number of cases are being reported every year. The assessment of platelet count and platelet indices at an early stage in the disease helps to predict the life-threatening complications such as Dengue Haemorrhagic Fever and Dengue Shock Syndrome. Materials and Methods: The current case-control study was undertaken at Sambhram Institute of Medical Sciences and Research, a rural tertiary care and teaching hospital in Kolar Gold Fields. During the recent dengue outbreak between June 2019 to August 2019 where in 75 seropositive cases of dengue were reported following clinical examination. Platelet count and platelet indices (Mean Platelet Volume, Platelet Distribution Width, Plateletcrit and Platelet-Large Cell Ratio) were carried out for these cases and results were tabulated. Similar tests were carried out on 75 apparently healthy controls and required parameters were obtained. Results: Platelet counts ranged from 11-429 x 10 3 mm 3 . 58 cases (77.33%) had thrombocytopenia. MPV ranged from 8-14 fL. 15 cases (20%) had increased MPV >12 fL. PDW ranged from 9-22.4. 21 cases (28%) had increased PDW > 14fL. PCT ranged from 0.04-0.36 %. 60 cases (80%) had low plateletcrit<0.22%. P-LCR ranged from 12.8-52.4 %. 13 cases (17.33%) had increased P-LCR > 35 %. Statistically significant p values were found for Platelet count (p<0.0001), MPV (p=0.0006) and PCT (p=0.0003). The p-values for PDW (0.2966) and P-LCR (0.1229) were not found to be statistically significant. Conclusion:Although dengue fever is predominant in urban and semi urban areas, an increasing in number of cases are being reported in rural areas. Platelet indices can be an early predictor of complications in dengue fever and thus benefit both Pathologists and Clinicians alike to forsee high-risk cases. It is an easily available, fast and cost effective means to ensure prompt management in a rural centers with limited resources. Platelet count, Mean platelet volume and Plateletcrit were found to be significant prognostic markers in the present study.

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“…In present study, thrombocytopenia (platelet count <1 lakh/mm 3 Chatterjee et al, thrombocytopenia was observed in 69.15%, 84.66%, 62%, 60% and 55.5% respectively. 9,12,13 The levels of AST and ALT (>40 IU/L) were elevated in 39 (29.54.%) case and 32 (24.44%), analogous findings of AST and ALT were observed by Khan et al, 40.66% and 28% respectively. 9 However, in a study done by Deshwal et al, AST was raised in 88.5% and ALT was raised in 88% cases.…”

Section: Discussionsupporting

confidence: 64%

A study of clinical and laboratory profile of dengue positive cases in hadoti region Rajasthan, India

Meena¹,

Meena²,

Meena³

2020

Int J Res Med Sci

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Background: Dengue fever is one of the most common arboviral mediated outbreaks reported with increased prevalence year after year with considerable morbidity and mortality in hadoti region. the aim to study various clinical and laboratory manifestations of Dengue fever admitted in MBS Hospital KOTA, with a diagnosis of Dengue fever according to WHO protocol from December 2018 to January 2020.Methods: Prospective observational study was undertaken among adult patients. 132 patients were studied and analysed. And diagnosis was confirmed with Dengue IgM ELISA test. Other routine investigations done were routine hematological and biochemical investigations.Results: A total of 132 cases, out of which 95 cases of Dengue Fever (DF), 34 cases of dengue hemorrhagic fever and 3 cases of Dengue Shock syndrome, out of which Male: Female ratio was 2.1. and mean age of presentation was 37. Fever and myalgia were the most common finding (100%) followed by arthralgia and headache. Pruritus was found in 21 cases (15.9%) which carried a significant difference between DF and DHF (p value <0.05). Among the laboratory features, thrombocytopenia and hematocrit were found to be statistically significant in DHF patients (p value <0.05). Mean platelet count was 0.71 lakhs/mm3. Leukopenia in 40(30.3%) cases. Raised Serum Aminotransferase level, AST (>40 IU/L) was seen in 39 cases (29.54%.). Pleural effusion was seen in 4 cases (3%), of which 3 cases of DHF and 1 case of DSS. Ascites in 6 cases (4.8%), all cases belong to DHF. Gall bladder wall thickening was seen in 28 cases (21.21%) of which 20 cases (54.04%) were of DHF. Melena was the most common bleeding manifestation. Skin rash was found to be positive in 40.5% cases. Hess test was positive in 4 cases (10.8% of DHF).Conclusions: Incidence of dengue fever is on the rise in hadoti region and one of the most important differential diagnosis of patients presenting with fever during monsoon and post monsoon seasons.

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Screening and manifestations of seropositive dengue fever patients in Perambalur: A Hospital based study

Cited by 8 publications

References 8 publications

Study of platelet indices in dengue fever with thrombocytopenia and correlation of immature platelet fraction (IPF) with platelet recovery

Study of platelet indices in dengue fever with thrombocytopenia and correlation of immature platelet fraction (IPF) with platelet recovery

Assessment of Platelet Indices as Prognostic Markers in Seropositive Cases of Dengue

A study of clinical and laboratory profile of dengue positive cases in hadoti region Rajasthan, India

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