<scp>TAK</scp>1 deficiency in dendritic cells inhibits adaptive immunity in <scp>SRBC</scp>‐immunized C57<scp>BL</scp>/6 mice

Pan, Yao; Lei, Zhiming; Wei, Xuetao; Hao, Weidong

doi:10.1002/2211-5463.12062

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Additionally, TEXs shuttle vast amounts of tumor-promoting RNAs such as micro-RNAs (miRNAs), which can target different processes in different cells and thus spread immunosuppression transversally through the immune system. For example, miRNAs such as miR-584, miR-517c and miR-378 target and downregulate TGF-β-associated kinase 1 (TAK1), which is necessary for the generation and function of DCs [53,54]. While mechanisms for TEX-dependent immunosuppression accumulate every day, it is becoming evident that TEXs have the potential to impair DC development, support TAM and Treg cells differentiation and to suppress the activity of natural killer (NK) cells and cytotoxic T lymphocytes (CTL) [52,54].…”

Section: Tumor Immune Microenvironmentmentioning

confidence: 99%

Polyphenols as Immunomodulatory Compounds in the Tumor Microenvironment: Friends or Foes?

Focaccetti

Izzi

Benvenuto

et al. 2019

IJMS

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Polyphenols are natural antioxidant compounds ubiquitously found in plants and, thus, ever present in human nutrition (tea, wine, chocolate, fruits and vegetables are typical examples of polyphenol-rich foods). Widespread evidence indicate that polyphenols exert strong antioxidant, anti-inflammatory, anti-microbial and anti-cancer activities, and thus, they are generally regarded to as all-purpose beneficial nutraceuticals or supplements whose use can only have a positive influence on the body. A closer look to the large body of results of years of investigations, however, present a more complex scenario where polyphenols exert different and, sometimes, paradoxical effects depending on dose, target system and cell type and the biological status of the target cell. Particularly, the immunomodulatory potential of polyphenols presents two opposite faces to researchers trying to evaluate their usability in future cancer therapies: on one hand, these compounds could be beneficial suppressors of peri-tumoral inflammation that fuels cancer growth. On the other hand, they might suppress immunotherapeutic approaches and give rise to immunosuppressive cell clones that, in turn, would aid tumor growth and dissemination. In this review, we summarize knowledge of the immunomodulatory effects of polyphenols with a particular focus on cancer microenvironment and immunotherapy, highlighting conceptual pitfalls and delicate cell-specific effects in order to aid the design of future therapies involving polyphenols as chemoadjuvants.

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Section: Tumor Immune Microenvironmentmentioning

confidence: 99%

Polyphenols as Immunomodulatory Compounds in the Tumor Microenvironment: Friends or Foes?

Focaccetti

Izzi

Benvenuto

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…The immune-enhancement function of OR in the mice was evaluated in the same dose range (0.1, 1.0, and 3.0 g/kg BW), and several tests regarding immunomodulatory evaluation were conducted (Fang et al, 2014;Pan et al, 2016;Pan et al, 2013;Xu et al, 2008;Yu et al, 2016).…”

Section: Immunomodulatory Evaluation In Micementioning

confidence: 99%