Dendritic cells (
DC
s) are important in the initiation of primary T‐cell responses, while transforming growth factor‐β (
TGF
‐β)‐activated kinase 1 (
TAK
1) is a critical regulator of
DC
survival and homeostasis. This study evaluated the T‐cell dependent antibody response (
TDAR
) to sheep red blood cells (
SRBC
) on a
DC
‐specific
TAK
1‐deficient mice model. The results showed that
TAK
1 deficiency in
DC
s significantly suppressed the humoral and cellular immune response in mice.
DC
‐specific
TAK
1 deletion impaired splenic T‐cell population and conventional
DC
s, abolished the cytokine production of splenic T cells and down‐regulated some functional gene expression in the spleen. Collectively, this study suggests that
TAK
1 plays an essential role in the development of the humoral immune response.
Underground pipeline corridor is a part of the construction of Smart City. There are many kinds of pipelines in it. Because of the complex air composition and special space structure, it is impossible to carry out high-frequency manual maintenance. Therefore, in order to ensure the safe operation of pipeline corridor, it is necessary to monitor its working environment in real time. In this paper, a low-power Internet of Things (IOT) system is designed for the special environment of underground pipeline gallery. The system’s network is built by low-power ZigBee module. Cooperated with micro-sensors, it can monitor the environment of pipeline gallery in real time, and the low-power of the system can make up for the long-term unattended situation of pipeline gallery. This paper also designs a sensor packaging technology for this environment, which protects the sensor from corrosion in the corridor environment without affecting the smooth network. Finally, the material is tested.
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