Application of dendritic cells in tumor immunotherapy and progress in the mechanism of anti-tumor effect of Astragalus polysaccharide (APS) modulating dendritic cells: a review

Dong, Wei; Cui, Qian; Yang, Yan Jie; Liu, A.Qing; Zhang, Guan; Yu, Jian Chun

doi:10.1016/j.biopha.2022.113541

Cited by 27 publications

(14 citation statements)

References 139 publications

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“…Tumor cells affect or limit the function of dendritic cells (DCs) antigen presentation via releasing growth factors and cytokines, such as vascular endothelial growth factor (VEGF) and IL-10, which finally leads to tumor immune escape (12). Thus, even with s u ffi c i e n t n u m b e r s o f D C s i n fi l t r a t i n g t h e t u m o r microenvironment, they do not perform their normal functions.…”

Section: Tumor Microenvironment Modulationmentioning

confidence: 99%

“…In addition, a large number of studies have indicated that these natural polysaccharides have significant anti-tumor effects without obvious side effects ( 2 , 10 ). Therefore, a diversity of natural polysaccharides, such as Astragalus polysaccharide, Ginseng polysaccharide, lentinan, fucoidan, Coriolus versicolor polysaccharide and pachman, have already become clinical drugs ( 3 , 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

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Immunomodulatory function and anti-tumor mechanism of natural polysaccharides: A review

Yang

2023

Front. Immunol.

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Polysaccharides extracted from natural resources have attracted extensive attention in biomedical research and pharmaceutical fields, due to their medical values in anti-tumor, immunomodulation, drug delivery, and many other aspects. At present, a variety of natural polysaccharides have been developed as adjuvant drugs in clinical application. Benefit from their structural variability, polysaccharides have great potential in regulating cellular signals. Some polysaccharides exert direct anti-tumor effects by inducing cell cycle arrest and apoptosis, while the majority of polysaccharides can regulate the host immune system and indirectly inhibit tumors by activating either non-specific or specific immune responses. As the essential of microenvironment in the process of tumor development has been gradually revealed, some polysaccharides were found to inhibit the proliferation and metastasis of tumor cells via tumoral niche modulation. Here, we focused on natural polysaccharides with biomedical application potential, reviewed the recent advancement in their immunomodulation function and highlighted the importance of their signaling transduction feature for the antitumor drug development.

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Section: Tumor Microenvironment Modulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immunomodulatory function and anti-tumor mechanism of natural polysaccharides: A review

Yang

2023

Front. Immunol.

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“…And, the ratio of immune cell composition differs significantly between the two groups. However, immune cells are widely established to be directly associated with tumor growth (31)(32)(33)(34)(35) or anti-tumor treatment (36)(37)(38)(39). Therefore, comprehensive analysis of the above, we presume that riskScore may influence patient prognosis via the TIME.…”

Section: Discussionmentioning

confidence: 99%

Identification of the mitophagy-related diagnostic biomarkers in hepatocellular carcinoma based on machine learning algorithm and construction of prognostic model

Cao²,

Zhou³

et al. 2023

Front. Oncol.

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Background and aimsAs a result of increasing numbers of studies most recently, mitophagy plays a vital function in the genesis of cancer. However, research on the predictive potential and clinical importance of mitophagy-related genes (MRGs) in hepatocellular carcinoma (HCC) is currently lacking. This study aimed to uncover and analyze the mitophagy-related diagnostic biomarkers in HCC using machine learning (ML), as well as to investigate its biological role, immune infiltration, and clinical significance.MethodsIn our research, by using Least absolute shrinkage and selection operator (LASSO) regression and support vector machine- (SVM-) recursive feature elimination (RFE) algorithm, six mitophagy genes (ATG12, CSNK2B, MTERF3, TOMM20, TOMM22, and TOMM40) were identified from twenty-nine mitophagy genes, next, the algorithm of non-negative matrix factorization (NMF) was used to separate the HCC patients into cluster A and B based on the six mitophagy genes. And there was evidence from multi-analysis that cluster A and B were associated with tumor immune microenvironment (TIME), clinicopathological features, and prognosis. After then, based on the DEGs (differentially expressed genes) between cluster A and cluster B, the prognostic model (riskScore) of mitophagy was constructed, including ten mitophagy-related genes (G6PD, KIF20A, SLC1A5, TPX2, ANXA10, TRNP1, ADH4, CYP2C9, CFHR3, and SPP1). ResultsThis study uncovered and analyzed the mitophagy-related diagnostic biomarkers in HCC using machine learning (ML), as well as to investigate its biological role, immune infiltration, and clinical significance. Based on the mitophagy-related diagnostic biomarkers, we constructed a prognostic model(riskScore). Furthermore, we discovered that the riskScore was associated with somatic mutation, TIME, chemotherapy efficacy, TACE and immunotherapy effectiveness in HCC patients.ConclusionMitophagy may play an important role in the development of HCC, and further research on this issue is necessary. Furthermore, the riskScore performed well as a standalone prognostic marker in terms of accuracy and stability. It can provide some guidance for the diagnosis and treatment of HCC patients.

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“…Astragalus polysaccharide is a herbal monomer extracted from the Chinese herb Astragalus membranaceus. Numerous studies have found [37] that Astragalus polysaccharide has important pharmacological effects in inhibiting tumor cell proliferation, inducing tumor cell apoptosis, and regulating immunity.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Careolizumab combined with chemotherapy and astragalus polysaccharide(APS) in patients with intermediate to advanced NSCLC and effects on lymphocyte subsets, regulatory T cells and serum tumor markers

Dong

Wan

2023

Preprint

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Objctive:To observe the recent efficacy of the combination group on patients with intermediate to advanced non-small cell lung cancer (NSCLC) and the effects on lymphocyte subsets, regulatory T cells, serum cytokeratin 19 fragment (CYFRA21-1), angiopoietin-2 (Ang-2), and vascular endothelial growth factor (VEGF). Methods:188 patients with intermediate to advanced NSCLC admitted to our hospital from August 2021 to April 2023 were selected, and the patients were simply randomly divided into a combination group and a control group. The control group was treated with chemotherapy regimen, and the combination group was treated with Carelizumab and astragalus polysaccharide on top of it. The recent efficacy, lymphocyte subsets (B, NK, CD3+,CD4+, CD4+/CD8+), regulatory T cells (CD4+Treg) , serum tumor markers CYFRA21-1, carcinoembryonic antigen (CEA), tumor antigen 125 (CA125), neurospecific enolase (NSE)] and angiogenic indexes (Ang-2, VEGF). Results:The total effective rate of recent clinical efficacy in the combined group after treatment was 69.15%, which was significantly higher than that in the control group (38.3%) (P<0.05). After treatment, the levels of B, NK, CD3+, CD4+ and CD4+/CD8+ were reduced in both groups, and the levels in the combined group were higher than those in the control group (P<0.05); the levels of CYFRA21-1, CEA, CA125 and NSE were reduced in both groups, and the levels in the combined group were significantly lower than those in the control group (P<0.05); the levels of Ang-2 and The levels of Ang-2 and VEGF were reduced in both groups, and the levels of Ang-2 and VEGF in the combined group were significantly lower than those in the control group (P<0.05). Progression-free survival was higher in the combination group than in the control group (95% CI, 1.468-4.278; Log-rank P < 0.0001; HR, 2.506). Conclusion: Carelizumab combined with chemotherapy and astragalus polysaccharide has definite near-term efficacy in patients with intermediate to advanced NSCLC, and can reduce the impact on immune function, prolong patients' progression-free survival, significantly improve serum tumor marker levels and play a certain inhibitory effect on angiogenesis.

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Application of dendritic cells in tumor immunotherapy and progress in the mechanism of anti-tumor effect of Astragalus polysaccharide (APS) modulating dendritic cells: a review

Cited by 27 publications

References 139 publications

Immunomodulatory function and anti-tumor mechanism of natural polysaccharides: A review

Immunomodulatory function and anti-tumor mechanism of natural polysaccharides: A review

Identification of the mitophagy-related diagnostic biomarkers in hepatocellular carcinoma based on machine learning algorithm and construction of prognostic model

Efficacy of Careolizumab combined with chemotherapy and astragalus polysaccharide(APS) in patients with intermediate to advanced NSCLC and effects on lymphocyte subsets, regulatory T cells and serum tumor markers

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