<scp>RANKL</scp> is associated with persistent primary teeth and delayed permanent tooth emergence

Arid, Juliana; Xavier, Thaís Aparecida; Rossi, Andiara De; Silva, Léa Assed Bezerra da; Queiroz, Alexandra Mussolino de; Galo, Rodrigo; Antunes, Lívia Azeredo Alves; Silva, Marcelo José Barbosa; Antunes, Leonardo Santos; Abbasoğlu, Zerrin; Filho, Paulo Nelson; Küchler, Érika Calvano; Fukada, Sandra Yasuyo

doi:10.1111/ipd.12467

Cited by 14 publications

(9 citation statements)

References 27 publications

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“…The authors identified that a total of 51 different variations of the PTH1R (parathyroid hormone 1 receptor) gene were associated with the primary failure of eruption [ 12 ]. More recently, some studies have also raised the suggestion that the mild forms of tooth eruption alterations, such as delayed tooth eruption with or without PPT, also have a genetic background involved in its etiology [ 4 , 13 , 14 , 15 ]. Variations (SNPs) in genes such as the receptor activator of NF-κB ligand (RANKL) [ 13 ] and Matrix metalloproteases 8 (MMP8) [ 14 ] could be involved in this common condition.…”

Section: Discussionmentioning

confidence: 99%

“…More recently, some studies have also raised the suggestion that the mild forms of tooth eruption alterations, such as delayed tooth eruption with or without PPT, also have a genetic background involved in its etiology [ 4 , 13 , 14 , 15 ]. Variations (SNPs) in genes such as the receptor activator of NF-κB ligand (RANKL) [ 13 ] and Matrix metalloproteases 8 (MMP8) [ 14 ] could be involved in this common condition. Since all cases of tooth agenesis (excluding third molars agenesis) were excluded from our study, it is worth mentioning that all PPT cases also present with the delayed permanent tooth eruption of its successor.…”

Section: Discussionmentioning

confidence: 99%

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Single Nucleotide Polymorphisms in COX2 Is Associated with Persistent Primary Tooth and Delayed Permanent Tooth Eruption

Küchler

Henklein

Proff

et al. 2022

IJERPH

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Persistent primary tooth (PPT) is a prevalent clinical condition that occurs when a primary tooth is over-retained beyond the established period of its normal exfoliation time, remaining in the oral cavity. Many factors could be involved in the risk of PPT; therefore, the aim of this study was to evaluate if single nucleotide polymorphisms (SNPs) in the COX2 gene are associated with PPT. Children undergoing orthodontic treatment were screened. Orthopantomographs were assessed to evaluate PPT according to the Nolla stage of its permanent successor. The primary tooth was considered retained when its successor permanent tooth was in Nolla stage 8 and below the alveolar crypt, Nolla stage 9, or Nolla stage 10. A saliva sample from each child was collected and used for DNA extraction. A real-time PCR of two SNPs, rs689466 (−1195 G/A) and rs5275 (+665 T/C), was performed. A chi-square test was used to compare the allele and genotype distribution. Haplotype analysis was also performed. A total of 100 children were included in the study. Fifty-one had at least one PPT, while 49 children were classified as a control. The number of teeth persistent in the oral cavity ranged from 1 to 8. The genotype distribution was associated with PPT in the co-dominant model (p = 0.006) for SNP rs5275. The individuals that carry two T alleles (TT) compared with the individuals that carry at least one C allele (C + TC) had an almost three times higher chance of presenting with PPT (p = 0.012; OR = 2.99, CI95% 1.28 to 6.95–recessive model). The haplotype C-A for the SNPs rs5275 and rs689466, respectively, was significantly associated (p = 0.042). In conclusion, single nucleotide polymorphisms in the gene encoding for COX2 are associated with persistent primary tooth and may delay permanent tooth eruption.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in COX2 Is Associated with Persistent Primary Tooth and Delayed Permanent Tooth Eruption

Küchler

Henklein

Proff

et al. 2022

IJERPH

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“…DTE is the most encountered deviation from normal eruption. 68 Gaucher disease, glycogen storage disorder types 1a and 1b, I-cell disease (mucolipidosis II), mucopolysaccharidoses (predominantly Hurler Scheie, Hunter and Maroteaux Lamy syndrome) 25,69 portray systemic conditions with a predilection for DTE. Moreover, local factors such as cleft lip and palate, bony pathology, and supernumerary teeth that occur as part of certain IEM have a possibility to cause a localised DTE.…”

Section: Considerations In the Dental Management Of Metabolic Disordersmentioning

confidence: 99%

“…Delayed tooth eruption (DTE) describes a statistically significant delayed eruption of a tooth (or teeth) compared to predefined norms for age, sex, and ethnicity. DTE is the most encountered deviation from normal eruption 68 . Gaucher disease, glycogen storage disorder types 1a and 1b, I‐cell disease (mucolipidosis II), mucopolysaccharidoses (predominantly Hurler Scheie, Hunter and Maroteaux Lamy syndrome) 25,69 portray systemic conditions with a predilection for DTE.…”

Section: Introductionmentioning

confidence: 99%

Inborn errors of metabolism and their impact in paediatric dentistry

Hirst

Chakrapani

Mubeen

2022

J of Inher Metab Disea

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The management of paediatric patients with inborn errors of metabolism (IEM) presents an unparalleled challenge for paediatric dentists owing to the multiplex of interrelated dental manifestations and metabolic management necessitating modifications to dental care. Inborn errors of metabolism describe a largely heterogenous group of genetic disorders namely attributable to a single gene defect essential for a specific metabolic pathway. Approximately 400 disorders have been described with an overall incidence of 1 in 5000 live births worldwide. Clinical presentation is classically inconspicuous and insidious in the neonatal period with pathophysiology attributable to accumulation of toxic by‐products which interfere with normal function, or insufficient synthesis of essential compounds. This paper aims to discuss the primary oral and maxillofacial manifestations across the scope of inborn errors of metabolism, whilst also considering how metabolic treatment has the propensity to complicate dental management.

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“…The incidence of ectopic eruption is 15.70%, its timely diagnosis is essential to plan a timely and effective treatment and thus avoid damage to the occlusion and costly orthodontic treatments. Arid, J, (2019). The teeth that have a predilection for erupting ectopically are the permanent third molars, followed by the maxillary canines and first molars constituting 0.8 to 2.8%.…”

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confidence: 99%

Prevalence of ectopic eruption and intercanine distance in children aged 6 to 12 years. Cycle 2019-2020

MARTÍNEZ-ORTIZ¹,

TAVIZON-GARCÍA²,

Carlos-Sánchez³

et al. 2021

CIERMMI Women in Science Medicine and Health Sciences Handbooks T-Xiii

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The development of permanent teeth and their eruption is of utmost clinical importance, it is also useful in anthropology, demography, forensic medicine and paleontology studies. When the eruption sequence and the mechanisms are not adequate, it causes an ectopic eruption that must be detected in time in order to avoid damage to the occlusion that affects the aesthetics, function, self-esteem and quality of life of the child. Objective: To identify the prevalence of ectopic eruption and intercanine distance in children aged 6 to 12 years. Methodology: An epidemiological, cross-sectional, descriptive study was carried out in order to clinically detect this eruption anomaly. The selection of the sample was 77 children who met the selection criteria, during the 2019-2020 school year. In a rural primary school in a municipality of Zacatecas, the intercanine distance measurements were subsequently carried out with the help of a Vernier, after calibration and informed consent, the information was processed through the statistical program SPSS V 24 and Excel. Results: The prevalence of ectopic eruption was 22%, the female gender the most frequent age was 7 years. The average upper intercanine distance was 26.76mm * - and in the lower jaw it was 33.4mm + _: the tooth that presented the most frequent ectopic eruption was No. 22, the least frequent was 32 and 15. It was observed a decrease in the intercanine distance 26.7mm. In children with multiple ectopic eruption, the intercanine distance decreased, the lower lateral incisors were detected between the teeth with the highest prevalence of ectopic eruption. Conclusions: It is necessary to intervene in the early stages in order to avoid the installation of malocclusion and costly, long and more difficult orthodontic treatments. Prevention is better than cure.

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RANKL is associated with persistent primary teeth and delayed permanent tooth emergence

Cited by 14 publications

References 27 publications

Single Nucleotide Polymorphisms in COX2 Is Associated with Persistent Primary Tooth and Delayed Permanent Tooth Eruption

Single Nucleotide Polymorphisms in COX2 Is Associated with Persistent Primary Tooth and Delayed Permanent Tooth Eruption

Inborn errors of metabolism and their impact in paediatric dentistry

Prevalence of ectopic eruption and intercanine distance in children aged 6 to 12 years. Cycle 2019-2020

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