miR ‐378a regulates keratinocyte responsiveness to interleukin‐17A in psoriasis*

Abstract

The study was approved by the Stockholm Regional Ethics Committee and conducted according to the Declaration of Helsinki principles. Written informed consent was obtained from all participants prior to enrolment.

miR ‐378a: an amplifier of the interleukin‐17A response in keratinocytes

“…In this issue of the BJD, Xia and colleagues systematically investigated the interplay between miR-378a and IL-17A in human keratinocytes. 6 Sequencing of small RNAs showed miR-378a to be overexpressed in keratinocytes isolated from lesional psoriatic skin compared with nonlesional psoriatic skin and healthy skin, a finding that was also previously published by the same group. 7 In a psoriasis mouse model, intradermal injection of miR-378a was found to exacerbate psoriasis-like skin inflammation, suggesting that increased levels of miR-378a in psoriatic keratinocytes contribute to the pathogenesis.…”

“…In this issue of the BJD , Xia and colleagues systematically investigated the interplay between miR‐378a and IL‐17A in human keratinocytes 6 . Sequencing of small RNAs showed miR‐378a to be overexpressed in keratinocytes isolated from lesional psoriatic skin compared with nonlesional psoriatic skin and healthy skin, a finding that was also previously published by the same group 7 .…”

“…Therefore, based on the work of Yen et al, we may be confident that the guideline with the least risk of providing biased or problematic recommendations is that from EuroGuiDerm, 1 followed by the other British, French and German guidelines. [5][6][7][8] This article provides an excellent summary of the available guidelines on psoriasis and describes their quality. Therefore, it should be a must-read article for dermatologists treating patients with psoriasis, for decision makers interested in psoriasis treatment and for anyone interested in using, adapting or implementing the best guidelines for their context.…”

Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment

“…Psoriasis is a multifaceted, chronic inflammatory skin disorder characterized by a complex pathogenesis, in which ncRNA classes, such as long ncRNAs and especially miRNAs, have been established to be deregulated and to play essential roles [ 15 , 48 , 54 – 56 ]. In addition, we have previously shown that global circRNA abundance is decreased in lesional relative to non-lesional skin of psoriatic patients [ 16 , 46 ].…”

“…In particular, miR-203a-3p was shown to be enriched in psoriatic skin lesions and to possess a critical role in disease progression by targeting genes involved in epidermal differentiation, such as p63 [ 63 ] and SOCS-3 [ 15 ], and in immune responses with targets like pro-inflammatory cytokines TNFα and IL-24 encoding transcripts [ 47 ]. In a recent study [ 56 ], miR-378a ectopic overexpression, mimicking the miRNA increase in psoriasis, was found to promote p63 transport to the nucleus and further contributed to the IL-17A-mediated activation of NF-κB pathway signaling by acting as suppressor of NFKBIA . While miR-378a was not included in the miRNA NanoString panel used in this study, we found miR-378i to be deregulated in skin biopsies.…”