miR ‐378a: an amplifier of the interleukin‐17A response in keratinocytes

Abstract

Last but not least, the rigour of development was also assessed as suboptimal in two-thirds of the guidelines. This AGREE II domain evaluates the methodological process applied for conducting an appropriate and transparent evidence synthesis and selection process, and the approach for formulating trustworthy and credible recommendations. This methodological process is the core of guideline development and is the factor that defines a real evidence-based guideline. Without meeting these methodological standards, guidelines are prone to biased recommendations.Using recommendations from low-quality guidelines may lead users to recommend treatments that are ineffective or harmful, are not implementable, are not acceptable by patients and have low or no value for money. Therefore, based on the work of Yen et al., we may be confident that the guideline with the least risk of providing biased or problematic recommendations is that from EuroGuiDerm, 1 followed by the other British, French and German guidelines. [5][6][7][8] This article provides an excellent summary of the available guidelines on psoriasis and describes their quality. Therefore, it should be a must-read article for dermatologists treating patients with psoriasis, for decision makers interested in psoriasis treatment and for anyone interested in using, adapting or implementing the best guidelines for their context.