Emerging roles of non-coding RNAs in psoriasis pathogenesis

Ghosh, Debakreeta; Ganguly, Torsa; Chatterjee, Raghunath

doi:10.1007/s10142-023-01057-5

Cited by 13 publications

(14 citation statements)

References 57 publications

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“…MicroRNAs has crucial roles in psoriasis, such as keratinocyte hyperproliferation (Ghosh et al 2023 ; Loganathan and Doss 2023 ; Xu et al 2017 ; Yu et al 2017 ), chemokine and cytokine production in keratinocytes (Shen et al 2017 ), alongside mediation of immune disorder (Fu et al 2015 ). Non-coding RNA modulated the miRNA activity through its miRNAs ‘‘sponges” function.…”

Section: Discussionmentioning

confidence: 99%

Small nucleolar RNA Snora73 promotes psoriasis progression by sponging miR-3074-5p and regulating PBX1 expression

Zhang,

Guo,

Zhang

et al. 2024

Funct Integr Genomics

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Chronic psoriasis is a kind of immune-mediated skin illness and the underlying molecular mechanisms of pathogenesis remain incompletely understood. Here, we used small RNA microarray assays to scan the differential expressed RNAs in psoriasis patient samples. The downstream miRNAs and its targets were predicted using bioinformatics analysis from online bases and confirmed using fluorescence in situ hybridization and dual‑luciferase report gene assay. Cell ability of proliferation and migration were detected using CCK-8 and transwell assays. The results showed that a new snoRNA Snora73 was upregulated in psoriasis patient samples. Overexpression of Snora73 significantly increased psoriasis cells viability and migration, while knockdown of Snora73 got the opposite results. Mechanistically, our results showed that Snora73 acted as a sponge for miR-3074-5p and PBX1 is a direct target of miR-3074-5p in psoriasis cells. Furthermore, miR-3074-5p suppressed psoriasis cell proliferation and migration, while PBX1 promoted cell proliferation and migration in psoriasis. Collectively, these findings reveal a crucial role of Snora73 in progression of psoriasis through miR-3074-5p/PBX1 signaling pathway and suggest a potential therapeutic strategy.

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Section: Discussionmentioning

confidence: 99%

Small nucleolar RNA Snora73 promotes psoriasis progression by sponging miR-3074-5p and regulating PBX1 expression

Zhang,

Guo,

Zhang

et al. 2024

Funct Integr Genomics

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“…Short ncRNAs include short interfering RNAs (siRNAs), Piwi-interacting RNAs (piR-NAs), and microRNAs (miRNAs); the latter are the most relevant regarding psoriasis. Micro RNAs are 17-25 nucleotides long and regulate gene expression, mainly gene silencing, by binding to and eventually leading to degradation of mRNA, modulating methylation of DNA or targeting enzymes necessary for DNA methylation, or histone modifications [4,73]. miRNA125b, one of the most downregulated miRNAs in psoriatic lesions, has been associated with suppression of keratinocyte proliferation and promotion of keratinocyte differentiation [74,75].…”

Section: Non Coding Rnamentioning

confidence: 99%

Genetic and Epigenetic Mechanisms of Psoriasis

Arrom

Puig

2023

Genes

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Psoriasis is a disease involving the innate and adaptative components of the immune system, and it is triggered by environmental factors in genetically susceptible individuals. However, its physiopathology is not fully understood yet. Recent technological advances, especially in genome and epigenome-wide studies, have provided a better understanding of the genetic and epigenetic mechanisms to determine the physiopathology of psoriasis and facilitate the development of new drugs. This review intends to summarize the current evidence on genetic and epigenetic mechanisms of psoriasis.

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“…The remaining 98% of the non-coding RNA (ncRNA) were considered irrelevant due to their non-coding ability for biologically active proteins (Mattick 2001 ; Statello et al 2021 ). Interestingly, in the 1990s, evidence for the involvement of small ncRNA and microRNA (miRNA) in several diseases emerged (Ghosh et al 2023 ; Dehaini et al 2019 ; Giordo et al 2021 , 2022 ; Hu et al 2022 ; Posadino et al 2022 ; Wehbe et al 2019 ). These raise the interest in other forms of ncRNA such as long non-coding RNA (lncRNA) (Li et al 2023 ), and the circular RNA (circRNA).…”

Section: Introductionmentioning

confidence: 99%

“…Most circRNAs are generated by exon hopping during pre-messenger RNA (pre-mRNA) transcription (Kelly et al 2015 ), which generates an exon-containing lariat structure that is subsequently internally spliced to release introns and form EciRNAs (Eger et al 2018 ). CircRNAs can regulate a variety of biological processes including tumor cell growth, apoptosis, inhibition of cell death, invasion and migration, and angiogenesis (Li et al 2023 ; Ghosh et al 2023 ; Loganathan and Doss 2023 ). Further, circRNAs interact with and modulate several cancer-associated intracellular pathways such as Wnt/beta-catenin, PIK3/AKT, and MAPK/ERK signaling (Solé and Lawrie 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer

Gopikrishnan

Ramanathan

et al. 2023

Funct Integr Genomics

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Circular RNAs (circRNAs) are regulatory elements that are involved in orchestrating gene expression and protein functions and are implicated in various biological processes including cancer. Notably, breast cancer has a significant mortality rate and is one of the most common malignancies in women. CircRNAs have been demonstrated to contribute to the pathogenesis of breast cancer including its initiation, progression, metastasis, and resistance to drugs. By acting as miRNA sponges, circRNAs can indirectly influence gene expression by disrupting miRNA regulation of their target genes, ultimately altering the course of cancer development and progression. Additionally, circRNAs can interact with proteins and modulate their functions including signaling pathways involved in the initiation and development of cancer. Recently, circRNAs can encode peptides that play a role in the pathophysiology of breast cancer and other diseases and their potential as diagnostic biomarkers and therapeutic targets for various cancers including breast cancer. CircRNAs possess biomarkers that differentiate, such as stability, specificity, and sensitivity, and can be detected in several biological specimens such as blood, saliva, and urine. Moreover, circRNAs play an important role in various cellular processes including cell proliferation, differentiation, and apoptosis, all of which are integral factors in the development and progression of cancer. This review synthesizes the functions of circRNAs in breast cancer, scrutinizing their contributions to the onset and evolution of the disease through their interactions with exosomes and cancer-related intracellular pathways. It also delves into the potential use of circRNA as a biomarker and therapeutic target against breast cancer. It discusses various databases and online tools that offer crucial circRNA information and regulatory networks. Lastly, the challenges and prospects of utilizing circRNAs in clinical settings associated with breast cancer are explored.

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Emerging roles of non-coding RNAs in psoriasis pathogenesis

Cited by 13 publications

References 57 publications

Small nucleolar RNA Snora73 promotes psoriasis progression by sponging miR-3074-5p and regulating PBX1 expression

Small nucleolar RNA Snora73 promotes psoriasis progression by sponging miR-3074-5p and regulating PBX1 expression

Genetic and Epigenetic Mechanisms of Psoriasis

Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer

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