Genetic and Epigenetic Mechanisms of Psoriasis

Arrom, Laura Mateu; Puig, L.

doi:10.3390/genes14081619

Cited by 11 publications

(6 citation statements)

References 129 publications

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“…Histones are proteins in the cell nucleus responsible for DNA packing, providing structural support for the chromosome, and regulating gene expression [18]. A nucleosome is a fundamental chromatin subunit consisting of a histone octamer of H2A, H2B, H3, and H4 proteins wrapped around 147 base pairs of DNA [65,66].…”

Section: Histone Modificationsmentioning

confidence: 99%

“…Epigenetics explores the impact of molecular modifications on the regulation of gene expression [17]. When it comes to the pathogenesis of psoriasis, significant epigenetic changes include deoxyribonucleic acid (DNA) methylation, non-coding RNA regulation, and histone modification [18]. Moreover, several microRNAs (miRNAs) have been identified as being capable of regulating the balance between skin cells' proliferation and differentiation, constituting the underlying cause of psoriatic lesions [19,20].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Epigenetic Factors in the Pathogenesis of Psoriasis

Olejnik-Wojciechowska,

Boboryko,

Bratborska

et al. 2024

IJMS

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Psoriasis is a chronic inflammatory skin disease, the prevalence of which is increasing. Genetic, genomic, and epigenetic changes play a significant role in the pathogenesis of psoriasis. This review summarizes the impact of epigenetics on the development of psoriasis and highlights challenges for the future. The development of epigenetics provides a basis for the search for genetic markers associated with the major histocompatibility complex. Genome-wide association studies have made it possible to link psoriasis to genes and therefore to epigenetics. The acquired knowledge may in the future serve as a solid foundation for developing newer, increasingly effective methods of treating psoriasis. In this narrative review, we discuss the role of epigenetic factors in the pathogenesis of psoriasis.

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Section: Histone Modificationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of Epigenetic Factors in the Pathogenesis of Psoriasis

Olejnik-Wojciechowska,

Boboryko,

Bratborska

et al. 2024

IJMS

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“…Gene candidates for innate immunity pathways in psoriasis have been found through numerous single nucleotide polymorphisms (SNPs) [83]. Transcription of these innate immune genes may reduce the threshold necessary to activate the pathogenic adaptive immune response [83,105]. NF-kB plays a critical role in mediating the transcription of several genes that participate in the innate response [107,108].…”

Section: Skinmentioning

confidence: 99%

Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis

Rusiñol,

Puig

2024

IJMS

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Psoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated inflammatory diseases (IMIDs). The prevalence of IMIDs is increasing in industrialized societies, influenced by both environmental changes and a genetic predisposition. However, the exact immune factors driving these chronic, progressive diseases are not fully understood. By using multi-omics techniques in cutaneous IMIDs, it is expected to advance the understanding of skin biology, uncover the underlying mechanisms of skin conditions, and potentially devise precise and personalized approaches to diagnosis and treatment. We provide a narrative review of the current knowledge in genomics, epigenomics, and proteomics of atopic dermatitis and psoriasis. A literature search was performed for articles published until 30 November 2023. Although there is still much to uncover, recent evidence has already provided valuable insights, such as proteomic profiles that permit differentiating psoriasis from mycosis fungoides and β-defensin 2 correlation to PASI and its drop due to secukinumab first injection, among others.

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“…The exact cause of psoriasis is not fully understood, but abnormal immune system activity, genetic factors, and environmental factors may all play a role in the development of the disease. Genetic factors play a crucial role in the pathogenesis of psoriasis, and individuals with psoriasis often have a family history of the condition [ 9 , 10 ]. The genetic basis of psoriasis is primarily associated with variations in genes related to the human leukocyte antigen (HLA) loci [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The high expression of TOP2A and MELK induces the occurrence of psoriasis

Zhu,

Zhang,

Qin

2024

Aging

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Background: Psoriasis is a chronic inflammatory skin disease. However, the influence of the TOP2A and MELK genes on psoriasis remains unclear. Methods: Psoriasis datasets GSE166388 and GSE181318 were downloaded from the Gene Expression Omnibus (GEO) database generated from GPL570 and GPL22120. Differential gene expression (DEGs) was identified. Functional enrichment analysis, gene set enrichment analysis (GSEA), weighted gene co-expression network analysis (WGCNA), and immune infiltration analysis were conducted. The protein-protein interaction (PPI) network was constructed and analyzed. Gene expression heat map was generated. The most relevant diseases associated with core genes were determined through comparison with the Comparative Toxicogenomics Database (CTD) website. TargetScan was used to select miRNAs regulating central DEGs. Results: A total of 773 DEGs were identified. According to Gene Ontology (GO) analysis, they were mainly enriched in mitochondrial gene expression, oxidative phosphorylation, mitochondrial envelope, mitochondria and ribosome. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that target cells were mainly enriched in metabolic pathways, proteasome, and oxidative phosphorylation. Seven core genes (TOP2A, NUF2, MELK, ASPM, DLGAP5, CCNA2, DEPDC1B) were obtained. The gene expression heatmap showed high expression of core genes (TOP2A, MELK) in psoriasis samples, while DEPDC1B, CCNA2, DLGAP5, NUF2, ASPM were lowly expressed in psoriasis samples. CTD analysis found that TOP2A and MELK were related to skin neoplasms, skin diseases, psoriasis, erythema, dermatitis, and infections. Conclusion: TOP2A and MELK genes are highly expressed in psoriasis, and higher expression of TOP2A and MELK genes is associated with poorer prognosis.

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Genetic and Epigenetic Mechanisms of Psoriasis

Cited by 11 publications

References 129 publications

The Role of Epigenetic Factors in the Pathogenesis of Psoriasis

The Role of Epigenetic Factors in the Pathogenesis of Psoriasis

Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis

The high expression of TOP2A and MELK induces the occurrence of psoriasis

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