m RNA Export

Abstract

The expression of protein‐coding genes is a multistep process that begins with transcription and processing of premessenger ribonucleic acid (pre‐mRNA) in the nucleus. The mature mRNA is then exported from the nucleus to the cytoplasm for translation into protein. Export of mRNA involves a specific cellular machinery that is highly conserved from yeast to humans.

Fingered for a Fat Fate

“…Gupta et al went on to investigate the role of Zfp423 in fat cell formation in vivo. Because mice lacking Zfp423 display developmental defects and poor viability (Cheng et al, 2007), day 18.5 embryos were compared for the amount of interscapular brown adipose tissue (BAT), the major adipose compartment during this developmental stage. Zfp423 null mice displayed a reduced mass of BAT and an increase in connective tissue intrusions.…”