Fingered for a Fat Fate

Schupp, Michael; Lazar, Mitchell A.

doi:10.1016/j.cmet.2010.02.014

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…Zinc finger protein 423 (Zfp423) which contains 30 Krüppel-like zinc fingers, was originally identified as a negative regulator of Ebf1 (early B cell factor 1), a basic transcription factor which participates in mesenchymal cell lineage determinations such as adipocyte and osteoblast differentiation [43–45]. It was recently discovered that Zfp423 directly participated in early adipose determination [22].…”

Section: Zinc Finger Proteins In White Adipogenesismentioning

confidence: 99%

Emerging roles of zinc finger proteins in regulating adipogenesis

Wei

Zhang

Zhou

et al. 2013

Cell. Mol. Life Sci.

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Proteins containing the zinc finger domain(s) are named zinc finger proteins (ZFPs), which are one of the largest classes of transcription factors in eukaryotic genomes. A large number of ZFPs have been studied and many of them were found to be involved regulating normal growth and development of cells and tissues through diverse signal transduction pathways. Recent studies revealed that a small but increasing number of ZFPs could function as key transcriptional regulators involved in adipogenesis. As the prevalence of obesity and metabolic disorders, the investigation of molecular regulatory mechanisms of adipocyte development must be more completely understood to develop novel and long term impact strategies for ameliorating obesity. In this review, we discuss recent work which has documented that ZFPs are important functional contributors to the regulation of adipogenesis. Taken altogether these data lead to the conclusion that ZFPs may become promising targets to combat human obesity.

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Section: Zinc Finger Proteins In White Adipogenesismentioning

confidence: 99%

Emerging roles of zinc finger proteins in regulating adipogenesis

Wei

Zhang

Zhou

et al. 2013

Cell. Mol. Life Sci.

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“…In adipogenesis, Zfp423 is found to be highly expressed in pre-adipocytes compared to non-committed NIH3T3 fibroblasts, and during adipogenesis, the activation of Zfp423 was potentiated by BMP/SMAD signaling and resulted in transactivation of peroxisome proliferator activated receptor-γ (PPARγ), a key transcription factor needed for the maturation of adipocytes ( 46 – 48 ). This function of Zfp423 is controlled by WNT1-inducible signaling pathway protein 2 (WISP2), a WNT pathway protein, which forms a WISP2–Zfp423 complex in the cytoplasm, which can be dissociated with BMP4/SMAD signaling, thus allowing Zfp423 to enter the nucleus for transcriptional activation of target genes ( 38 ).…”

Section: Znf423 In Development and Differentiationmentioning

confidence: 99%

ZNF423: A New Player in Estrogen Receptor-Positive Breast Cancer

et al. 2018

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Preventive therapy can target hormone-responsive breast cancer (BC) by treatment with selective estrogen receptor modulators (SERMs) and reduce the incidence of BC. Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) with relevant predictive values, SNPs in the ZNF423 gene were associated with decreased risk of BC during SERM therapy, and SNPs in the Cathepsin O gene with an increased risk. ZNF423, which was not previously associated with BC is a multifunctional transcription factor known to have a role in development, neurogenesis, and adipogenesis and is implicated in other types of cancer. ZNF423 is transcriptionally controlled by the homolog ZNF521, early B cell factor transcription factor, epigenetic silencing of the promoter by CpG island hyper-methylation, and also by ZNF423 itself in an auto-regulatory loop. In BC cells, ZNF423 expression is found to be induced by estrogen, dependent on the binding of the estrogen receptor and calmodulin-like 3 to SNPs in ZNP423 intronic sites in proximity to consensus estrogen response elements. ZNF423 has also been shown to play a mechanistic role by trans-activating the tumor suppressor BRCA1 and thus modulating the DNA damage response. Even though recent extensive trial studies did not classify these SNPs with the highest predictive values, for inclusion in polygenic SNP analysis, the mechanism unveiled in these studies has introduced ZNF423 as a factor important in the control of the estrogen response. Here, we aim at providing an overview of ZNF423 expression and functional role in human malignancies, with a specific focus on its implication in hormone-responsive BC.

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“…Recently, several studies have demonstrated that zinc nger protein 423 (Zfp423) is important for the adipocyte lineage commitment of MSCs [16,17].…”

Section: Introductionmentioning

confidence: 99%