<scp>HPV</scp> load and anal cytological abnormalities

Maia, LB; Marinho, Lc; Carneiro, MV; Bocca, Anamélia Lorenzetti; Neto, Ffc; Motoyama, AB; Muniz‐Junqueira, Maria Imaculada; Ferreira, Vmm; Carneiro, FP; Oliveira, Paulo Gonçalves de

doi:10.1111/hiv.12317

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…Considering that there is a lack of a classification system for HPV related- and malignant and pre-malignant lesions in oral cytology, Bethesda classification was chosen in the current study to proceed the cytological analysis. Such classification has already been used by some studies to classify oral cytological findings ( Solomon, 2015 ; Fakhry et al, 2011 ; Dalstein et al, 2003 ; Navone, 2009 ; Maia et al, 2016 ). By conventional cytology, the cytological smears analyzed showed good cellularity and the majority were negative (98%); ASC-US was diagnosed two cases.…”

Section: Discussionmentioning

confidence: 99%

Oropharynx HPV status and its relation to HIV infection

Vianna

Carneiro

Amorim

et al. 2018

PeerJ

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BackgroundThe number of oropharyngeal lesions caused by HPV (Human papillomavirus) has been increasing worldwide in the past years. In spite of the clinical relevance of HPV infection in the anogenital tract of HIV-positive patients, the relevance of oropharynx HPV infection in these patients is not clear. The aim of the present study was to detect HPV infection, and clinical and cytological changes in the oropharynx of HIV-positive patients.MethodsSamples collected from the oropharynx of 100 HIV-positive patients were subjected to hybrid capture (HC), conventional and liquid-based cytology. Clinical data were also collected to investigate the relation with HPV status.ResultsHigh and low-risk types of HPV were present in 8% and 16.7% of the total sample. The mean ± sd (maximum-minimum) of the relative ratio light unit (RLU)/cutoff (CO) was 2.94 ± 2.58 (1.09–7.87) and 1.61 ± 0.65 (1.07–2.8) for high- and low-risk-HPV, respectively. By cytology, dysplasia was not detected, but atypical squamous cells of undetermined significance (ASC-US) were diagnosed in two samples. No clinical change, suggestive of dysplasia/cancer, was detected.ConclusionOur study was able to detect and characterize HPV infection by hybrid capture, which may represent a good tool for screening and follow-up of HPV in the studied population. The frequency and viral load of HPV were low. Neither clinical nor cytological changes suggestive of dysplasia/neoplasia were observed in oropharynx of HIV-positive patients.

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Section: Discussionmentioning

confidence: 99%

Oropharynx HPV status and its relation to HIV infection

Vianna

Carneiro

Amorim

et al. 2018

PeerJ

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Screening Women for Anal Cancers: Guidance for Health Care Professionals

et al. 2021

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Anal cancer is rare in the general population but is steadily increasing in incidence over the past decade especially in women. Identification and screening of women with high risk facilitates detection of anal precancer and early-stage cancer, improves survival, and potentially uses less invasive therapies compared with the conventional chemoradiation treatments used for advanced cancers. No recently published guidelines currently describe details about screening women for anal squamous cell cancer (ASCC). The available evidence supports the existence of groups of women with higher prevalence of ASCC (e.g., women with human immunodeficiency virus, immune suppression, or previous lower-genital high-grade lesion or cancer) who would likely benefit from screening with some combination of anal cytology and human papillomavirus testing. Additional research is needed to establish the cost-effectiveness and the influence of screening on ASCC mortality rates.

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Anal human papillomavirus infection: prevalence, diagnosis and treatment of related lesions

Benevolo

Donà

Ravenda

et al. 2016

Expert Review of Anti-infective Therapy

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Human papillomavirus (HPV) infection is mostly asymptomatic, but may also have many diverse clinical signs encompassing benign ano-genital lesions, and carcinomas. Recently, interest has also particularly focused on anal cancer since, over the last decades, its incidence has been greatly increasing in developed countries, both in women and men and is drastically higher in specific risk groups, such as men who have sex with men (MSM) and HIV-1 infected individuals. Approximately 88% of anal cancer cases worldwide are associated with HPV infection. This review summarizes our current understanding of anal HPV infection, discussing its epidemiology and risk factors in various populations, and the state of the art in the detection of anal HPV infection and its related lesions through both cytology and histology. Finally, we discuss the clinical management and therapy for these lesions.

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HPV load and anal cytological abnormalities

Abstract: The estimated high-risk HPV viral load is significantly higher in samples with cytological abnormalities than in negative anal samples and may be useful as an adjunct to anal cytology for triage of patients to high-resolution anoscopy and biopsy.

Cited by 3 publications

References 19 publications

Oropharynx HPV status and its relation to HIV infection

Oropharynx HPV status and its relation to HIV infection

Screening Women for Anal Cancers: Guidance for Health Care Professionals

Anal human papillomavirus infection: prevalence, diagnosis and treatment of related lesions

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