Anal human papillomavirus infection: prevalence, diagnosis and treatment of related lesions

Benevolo, Maria; Donà, Maria Gabriella; Ravenda, Paola Simona; Chiocca, Susanna

doi:10.1586/14787210.2016.1174065

Cited by 26 publications

(37 citation statements)

References 129 publications

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“…132 The main risk factor for cervical cancer development is a long-term persistent infection with HR-HPV. 133 HPV infection has also been linked to the development of a proportion of vulvar, penile, 134,135 and HNSCC. 136 On the other hand, the β genus of cutaneous HPVs, such as HPV5 and HPV8, have been linked to nonmelanoma skin cancer (NMSC) driven by UV irradiation.…”

Section: Human Papillomavirusesmentioning

confidence: 99%

Deregulation of the Notch pathway as a common road in viral carcinogenesis

Vázquez-Ulloa

Lizano

Sjöqvist

et al. 2018

Reviews in Medical Virology

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The Notch pathway is a conserved signaling pathway and a form of direct cell-cell communication related to many biological processes during development and adulthood. Deregulation of the Notch pathway is involved in many diseases, including cancer. Almost 20% of all cancer cases have an infectious etiology, with viruses responsible for at least 1.5 million new cancer cases per year. Seven groups of viruses have been classified as oncogenic: hepatitis B and C viruses (HBV and HCV respectively), Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV), human T lymphotropic virus (HTLV-1), human papillomavirus (HPV), and Merkel cell polyomavirus (MCPyV). These viruses share the ability to manipulate a variety of cell pathways that are critical in proliferation and differentiation, leading to malignant transformation. Viral proteins interact directly or indirectly with different members of the Notch pathway, altering their normal function. This review focuses exclusively on the direct interactions of viral oncoproteins with Notch elements, providing a deeper understanding of the dual behavior of the Notch pathway as activator or suppressor of neoplasia in virus-related cancers.

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Section: Human Papillomavirusesmentioning

confidence: 99%

Deregulation of the Notch pathway as a common road in viral carcinogenesis

Vázquez-Ulloa

Lizano

Sjöqvist

et al. 2018

Reviews in Medical Virology

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“…Classifying cellular histology of anal lesions also employs the revised Bethesda System for Reporting Cervical Cytology [38, 39]. Sensitivity of detecting high-grade anal neoplasia ranges from 69–93% in several studies [38], and abnormal anal cytology should be further investigated with high resolution anoscopy (HRA), which is analogous to the cervical colposcopy [40, 41].…”

Section: Anal Cancermentioning

confidence: 99%

“…Sensitivity of detecting high-grade anal neoplasia ranges from 69–93% in several studies [38], and abnormal anal cytology should be further investigated with high resolution anoscopy (HRA), which is analogous to the cervical colposcopy [40, 41]. HPV DNA testing is controversial given the high prevalence of hrHPV viral infection in HIV-infected persons [39, 42]. However, presence of hrHPV genotype 16 is associated with concurrent high-grade anal lesions in women with HIV [43, 44].…”

Section: Anal Cancermentioning

confidence: 99%

Malignancies in women with HIV infection

Oliver

Chiao

2017

Current Opinion in HIV and AIDS

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Purpose of Review To review current knowledge of different cancer states affecting women with HIV infection. Recent Findings With improved survival of persons with HIV in the post-cART era, the landscape of malignancies in this population has greatly changed with fewer AIDS-defining malignancies (ADM) and a growing number of non-AIDS defining malignancies (NADM). Women, however, continue to represent a vulnerable population at risk for certain ADM and NADM such as cervical, anal, and breast cancer. Human papilloma virus-mediated cancers disproportionately burden women in resource-poor settings such as Subsaharan Africa. For cancers such as Kaposi’s Sarcoma, lung cancer, liver cancer, and colorectal cancer, women share a lower burden of disease compared to their male counterparts. However, there remains a dearth of evidence characterizing these disease states specifically among women. Summary Cancer in women with HIV continues to be a major source of morbidity and mortality worldwide, especially in low-income countries. Screening strategies, primary prevention through vaccination against human papillomavirus and viral hepatitis, and treatment for HIV with combined antiviral therapy remain cornerstones in cancer prevention.

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“…Both forms can co-exist and are usually evoked by different genotypes of HPV. Namely, benign AGW are more often evoked by lowrisk HPV types 6 and 11, whereas HPV types 16 and 18 produce higher risk lesions [4,16]. The vast majority of patients with AGW primarily carries HPV types 6 and 11.…”

mentioning

confidence: 99%

Efficacy of Generic Drug Wartocid® (Imiquimod 5% Cream for External Use) in Anogenital Warts Treatment

Смирнов¹,

Petlenko²,

Савельев³

et al. 2017

Russian Journal of Infection and Immunity

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Abstract. Aim. To evaluate the efficacy and safety of the generic drug Wartocid ® (Imiquimod cream 5% for external use) in patients with external anogenital (venereal) warts (AGW). Materials and methods. The single-blind comparative, randomized, placebo-controlled clinical trial included 50 women aged 18 to 60 with an established clinical diagnosis of AGW in the vulva and perianal region. Patients in group 1 received placebo cream for external use, while patients in group 2 received therapy with Wartoсid in a daily dose of 10 mg cream/cm 2 of skin area. The drug was applied every other day until the complete disappearance of AGW, but in any case, not more than 16 weeks. A follow-up was carried out for 4 more weeks. The study evaluated the dynamics of subjective and objective symptoms, the presence and the frequency of relapses, and the percentage of full treatment of AGW. Main results. Treatment with Wartoсid resulted in a complete cure of AGW in 16% of patients, and a reduction in the focus area of AGW in 36% of patients. Against the background of the placebo no dynamics of the disease were reached. Neither serious adverse events nor clinically significant changes in blood tests, urine or serum biochemical parameters in any of the patients who received treatment with Wartoсid were observed. Conclusion. The generic drug Wartocid has been proved to be effective and safe for AGW treatment and its effectiveness is similar to the original drug Aldara ® (Imiquimod cream 5% for external use). Резюме. Цель. Оценка эффективности и безопасности воспроизведенного препарата Вартоцид ® (Имихимод крем 5% для наружного применения) у пациентов с наружными аногенитальными (венерическими) боро-давками (АГБ). Материалы и методы. Простое слепое сравнительное рандомизированное плацебо-контро-лируемое клиническое исследование включало 50 женщин в возрасте от 18 до 60 лет с установленным кли-ническим диагнозом АГБ в вульве и перианальном регионе. Пациенты в группе 1 получали плацебо-крем для наружного применения, тогда как пациенты в группе 2 получали терапию Вартоцидом в суточной дозе 10 мг крема/см 2 области кожи. Препарат применялся через день до полного исчезновения АГБ, но в любом

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Anal human papillomavirus infection: prevalence, diagnosis and treatment of related lesions

Cited by 26 publications

References 129 publications

Deregulation of the Notch pathway as a common road in viral carcinogenesis

Deregulation of the Notch pathway as a common road in viral carcinogenesis

Malignancies in women with HIV infection

Efficacy of Generic Drug Wartocid® (Imiquimod 5% Cream for External Use) in Anogenital Warts Treatment

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