CRNDE: An important oncogenic long non‐coding RNA in human cancers

Abstract

Aberrant overexpression of long non-coding RNA CRNDE (Colorectal Neoplasia Differentially Expressed) is confirmed in various human cancers, which is correlated with advanced clinicopathological features and poor prognosis. CRNDE promotes cancer cell proliferation, migration and invasion, and suppresses apoptosis in complicated mechanisms, which result in the initialization and development of human cancers. In this review, we provide an overview of the oncogenic role and potential clinical applications of CRNDE.

LncRNA CRNDE is a biomarker for clinical progression and poor prognosis in clear cell renal cell carcinoma

“…7 In renal cell carcinoma, Shao et al performed loss-of-function and gain-of-function assays and found that CRNDE enhanced the cell proliferation and growth both in vitro and in vivo through regulating Wnt/β-catenin signaling. 7 In renal cell carcinoma, Shao et al performed loss-of-function and gain-of-function assays and found that CRNDE enhanced the cell proliferation and growth both in vitro and in vivo through regulating Wnt/β-catenin signaling.…”

“…CRNDE served as oncogenic lncRNA to promote tumor cell proliferation, migration and invasion in complicated mechanisms, which result in the initialization and development of human cancers. 7 In renal cell carcinoma, Shao et al performed loss-of-function and gain-of-function assays and found that CRNDE enhanced the cell proliferation and growth both in vitro and in vivo through regulating Wnt/β-catenin signaling. 9 However, the effect of CRNDE on ccRCC cell mobility was still unknown.…”

“…5 CRNDE was originally identified as an lncRNA, which was upregulated in colorectal adenomas and carcinomas tissues. 7 A human exon array showed that CRNDE was upregulated in ccRCC tissue samples compared with paired normal adjacent tissue samples. 7 A human exon array showed that CRNDE was upregulated in ccRCC tissue samples compared with paired normal adjacent tissue samples.…”

The role of long non‐coding RNAs in multiple myeloma

“…With seven exons, colorectal neoplasia differentially expressed (CRNDE), which is localized on chromosome 16q12 and encodes a 1.1-kb lncRNA, was first identified as a mediator of oncogenesis by promoting growth and suppressing apoptosis in colorectal adenomas and carcinomas. 74 Recent reports have demonstrated that CRNDE is able to regulate certain serum components with cell cycle, growth, and differentiation by binding specific transcription factors (TFs), such as Fosl, JunD, and SRF. 75 In addition, CRNDE may also play a role in the Myc regulatory pathway by binding with Max, which is one of the Myc partner proteins.…”

Emerging roles of non‐coding RNAs in scoliosis

“…[24][25][26][27][28][29][30] It therefore comes as no surprise that ncRNAs are deregulated in most, if not all, kinds of diseases, including neoplastic, inflammatory and metabolic diseases. [31][32][33][34][35] From a clinical perspective, the frequent alteration of ncRNA abundance in the body fluid, such as saliva, blood and urine, during diseases make this class of molecules promising candidates for development into biomarkers for early diagnosis and prognostication. [36][37][38] A growing body of evidence now suggests that deregulated expression of ncRNAs is a key to the development of orthopaedic diseases, including osteosarcoma, osteoporosis, osteoarthritis and intervertebral disc degeneration.…”