Scorpionicidal activity of secondary metabolites from Paecilomyces sp. CMAA1686 against Tityus serrulatus

Scorpion envenomation in Brazil: Current scenario and perspectives for containing an increasing health problem

“…have also been reported, causing behavioral changes similar to the ones reported for F. solani [156]. More recently, Brites-Neto and colleagues also sought for deleterious effects in T. serrulatus caused by fungi isolates [140]. An isolate identified as Paecilomyces sp.…”

“…Scorpions bear a condition that favors their visualization, as they become fluorescent in ultraviolet (UV) light [ 137 ], due to components of their exoskeleton [ 138 , 139 ]. Indeed, Brites-Neto and colleagues [ 140 ] reported that nocturnal specimen collection using UV light increased in 114% the annual mean of collected individuals, when compared to daily collection expeditions in the city of Americana, in São Paulo state. The number of accidents also decreased after adopting this collection methodology in this city.…”

“…More recently, Brites-Neto and colleagues also sought for deleterious effects in T . serrulatus caused by fungi isolates [ 140 ]. An isolate identified as Paecilomyces sp.…”

Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches

“…CMAA1686 isolated from a cemetery in Brazil, which includes pharmacologically active scorpionicidal (against Tityus serrulatus ) terpene lactones, phenylpropanoids, and alkaloids. 72 MolNetEnhancer can conveniently be run through the GNPS platform, 21 currently supporting in silico structural input from DEREPLICATOR, 73 a tool to annotate peptidic natural products, and Network Annotation Propagation. 41 In the future, it is anticipated that the output of other metabolite annotation tools such as DEREPLICATOR+, 60 which annotates besides peptides also other compound classes such as polyketides and flavonoids, and CANOPUS 37 will also be compatible with the MolNetEnhancer workflow.…”