Sclérose en plaques associée à une symptomatologie biologique évocatrice d'un lupus érythémateux disséminé Une observation avec étude anatomique

Lorcerie, B.; Marchal, G; Borsotti, J. P.; Guard, O; Giroud, M.; Dumas, R; Martin, F

doi:10.1016/s0248-8663(89)80058-x

Cited by 6 publications

(1 citation statement)

References 13 publications

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“…In SLE, support for the direct pathogenicity of anti-DNA antibodies derives from the close correlation between disease activity, particularly lupus nephritis, and levels of anti-DNA reactivity in serum, as well as from the ability of anti-DNA antibodies to induce disease in severe combined immunodeficient-and recombination-activating gene-1-deficient mice (38). Intriguingly, an estimated 40-70% of patients with SLE develop CNS involvement, including optic neuritis (39)(40)(41)(42)(43). Indeed, the term ''lupoid sclerosis'' is used to describe a patient presenting with clinical features of both MS and SLE.…”

Section: Resultsmentioning

confidence: 99%

Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis

Williamson

Burgoon

Owens

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

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Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of unknown cause that afflicts the central nervous system. MS is typified by a highly clonally restricted antigen-driven antibody response that is confined largely to the central nervous system. The major antigenic targets of this response and the role of antibody in disease pathogenesis remain unclear. To help resolve these issues, we cloned the IgG repertoire directly from active plaque and periplaque regions in MS brain and from B cells recovered from the cerebrospinal fluid of a patient with MS with subacute disease. We found that high-affinity anti-DNA antibodies are a major component of the intrathecal IgG response in the patients with MS that we studied. Furthermore, we show DNA-specific monoclonal antibodies rescued from two subjects with MS as well as a DNA-specific antibody rescued from an individual suffering from systemic lupus erythematosus bound efficiently to the surface of neuronal cells and oligodendrocytes. For two of these antibodies, cell-surface recognition was DNA dependent. Our findings indicate that anti-DNA antibodies may promote important neuropathologic mechanisms in chronic inflammatory disorders, such as MS and systemic lupus erythematosus.

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