Lupoid sclerosis

Keiserman, Briele; Silva, Luiz Fernando Garcias da; Keiserman, Mauro Waldemar; Mühlen, Carlos Alberto von; Staub, Henrique Luiz

doi:10.1007/s00296-009-1175-1

Cited by 13 publications

(6 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An association between lupus and MS-like brain changes have been suggested, and sometimes termed “lupoid sclerosis” ( 85 ). However, many such studies pre-date high quality MRI brain imaging which has greatly facilitated accurate diagnosis of MS. Much of this confusion stems from the superficial similarities between the presence of small white matter lesions on the MRI brain scans of patients with both MS and lupus.…”

Section: Clinical Approach In Neurolupusmentioning

confidence: 99%

Neurological Disease in Lupus: Toward a Personalized Medicine Approach

et al. 2018

View full text Add to dashboard Cite

The brain and nervous system are important targets for immune-mediated damage in systemic lupus erythematosus (SLE), resulting in a complex spectrum of neurological syndromes. Defining nervous system disease in lupus poses significant challenges. Among the difficulties to be addressed are a diversity of clinical manifestations and a lack of understanding of their mechanistic basis. However, despite these challenges, progress has been made in the identification of pathways which contribute to neurological disease in SLE. Understanding the molecular pathogenesis of neurological disease in lupus will inform both classification and approaches to clinical trials.

show abstract

Section: Clinical Approach In Neurolupusmentioning

confidence: 99%

Neurological Disease in Lupus: Toward a Personalized Medicine Approach

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Overlap of clinical and laboratory findings of multiple sclerosis (MS) and SLE have been described long ago, leading to the proposal of a hybrid condition named “lupoid sclerosis” ( 77 , 78 ). Diagnostic criteria, as well as the role of anti-nuclear antibodies (ANA) and aPL are still matter of debate ( 79 ). Several studies have provided different estimates of aPL prevalence in definite MS patients, ranging from 2 to 88% ( 80 ), with higher titers observed during exacerbations of the disease ( 81 ).…”

Section: Neurological Manifestations Of Apsmentioning

confidence: 99%

Antiphospholipid Syndrome and the Neurologist: From Pathogenesis to Therapy

2018

View full text Add to dashboard Cite

Antiphospholipid syndrome (APS) is an autoimmune antibody-mediated condition characterized by thrombotic events and/or pregnancy morbidity in association with persistent positivity to antiphospholipid antibodies (aPL). The nervous system is frequently affected, as intracranial vessels are the most frequent site of arterial pathology. Over the course of years, many other neurological conditions not included in the diagnostic criteria, have been associated with APS. The pathogenic mechanisms behind the syndrome are complex and not fully elucidated. aPL enhance thrombosis, interfering with different pathways. Nevertheless, ischemic injury is not always sufficient to explain clinical features of the syndrome and immune-mediated damage has been advocated. This may be particularly relevant in the context of neurological complications. The reason why only a subgroup of patients develop non-criteria nervous system disorders and what determines the clinical phenotype are questions that remain open. The double nature, thrombotic and immunologic, of APS is also reflected by therapeutic strategies. In this review we summarize known neurological manifestations of APS, revisiting pathogenesis and current treatment options.

show abstract

“…Arthritis isolated to the first TMTJ was also assessed using the "piano key test". 15 The presence of one or more of these signs was used to define the clinical presence of midfoot arthritis.…”

Section: Tibialis Anterior Passive Stretch (Taps) Testmentioning

confidence: 99%