Prevalence and Clinical Significance of Anti-phospholipid Antibodies in Multiple Sclerosis: a Study of 89 Patients

Roussel, V; Yi, Fan; Jauberteau, Marie‐Odile; Couderq, C; Lacombe, Christian; Michelet, V; Gil, Roger; Couratier, Philippe; Vallat, Jean‐Michel; Preud'homme, J L

doi:10.1006/jaut.2000.0367

Cited by 63 publications

(52 citation statements)

References 41 publications

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“…Contrary to our results, some studies have shown higher positivity of aCl IgG than aCl IgM in MS patients [16]. In our CIS cohort, 11.2% patients had positive aCI-IgG, and 19.8% aCIIgM titers.…”

Section: Discussioncontrasting

confidence: 55%

“…It is interesting that aCl IgG titers were weakly or moderately positive, while 21.7% of patients with positive aCl IgM had moderately to high titers. As well, although we did not find any correlation between ANA and aCl positivity, other have found opposite results [16]. Most of the published studies found no correlation between aCl and age, sex, disease duration, clinical classification, clinical evolution, or peculiar clinical symptoms.…”

Section: Discussioncontrasting

confidence: 48%

“…Recent studies showed a prevalence of aCl in MS patients of 4.8-44% of cases [11][12][13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

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Do we need broad immunological work-up in all patients with CIS?

Adamec

Bošković

Škvorc

et al. 2012

Journal of the Neurological Sciences

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Section: Discussioncontrasting

confidence: 55%

Section: Discussioncontrasting

confidence: 48%

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Do we need broad immunological work-up in all patients with CIS?

Adamec

Bošković

Škvorc

et al. 2012

Journal of the Neurological Sciences

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“…Há relatos na literatura de outros tipos de anticorpos coexistentes nos pacientes com EM além dos antitireoidianos, como anticorpo anti-RO (SS-A) 19 , antifosfolipídeo 20 , anticardiolipina 19,21 e antinuclear 19 .…”

Section: Discussionunclassified

Prevalência de anticorpos antimicrossomais em pacientes com esclerose múltipla

Vecino

Czepielewski

Freitas

et al. 2004

Arq. Neuro-Psiquiatr.

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RESUMO -O objetivo deste estudo consiste em avaliar a prevalência de anticorpos antimicrossomais (AAM), a função tireóidea e a ocorrência de sintomas relacionados ao hipotireoidismo em pacientes com esclerose multipla (EM). Em um grupo de 21 pacientes com EM, foi realizado exameclínico, foram dosados o TSH, T4 e T4 livre e pesquisados AAM. A média de idade foi 41,05 anos e a média de tempo de doença foi 85,9 meses. Os sintomas relacionados ao hipotireoidismo foram fadiga, fraqueza, letargia e parestesias. Os AAM foram encontrados em 4 pacientes (19%). O tempo de doença foi dividido em três períodos: <60 meses (3 pacientes AAM+/7AAM-), 60-120 meses (8 pacientes AAM-) e >120 meses (1 paciente AAM+/2 AAM-). Dois pacientes apresentaram níveis de T4 livre diminuídos, porém com T4 e TSH normais. Em 1 paciente, constatou-se hipotireoidismo subclínico, e em outro, hipotireoidismo clássico. Conclui-se que na avaliação dos pacientes com EM, em vista da falta de precisão na avaliação clínica do hipotireoidismo ocasionada pela sobreposição de sintomas referentes à EM, devam ser incorporadas as dosagens das provas de função tireóidea (PFT) e dos AAM.PALAVRAS-CHAVE: esclerose múltipla, anticorpos antimicrossomais, hipotireoidismo. Prevalence of antimicrosomal antibodies in patients with multiple sclerosisABSTRACT -The aim of this study was to assess the prevalence of Antimicrosomal Antibodies AMA, thyroid function and the occurrence of hypothyroidism symptoms in patients with Multiple Sclerosis (MS). Clinical examination was carried out in 21 MS patients; thyroid-stimulating hormone (TSH), thyroxine (T4), free T4 and AMA were measured. Mean age was 41.05 years. Hypothyroidism symptoms included fatigue, weakness, lethargy and paresthesia. AMA were found in four patients (19%). Three categories of disease duration were considered: <60 months (3 patients AMA+; 7 AMA-), 60-120 months (8 patients AMA-), and >120 months (1 patient AMA+; 2 AMA-). Two patients presented decreased free T4 levels, but there was no associated decrease in T4 and TSH levels. In two patients, a mild increase in TSH levels was observed: one presented normal T4 levels (subclinical hypothyroidism) and the other one had low free T4 levels (classical hypothyroidism). We conclude that AMA measurement and thyroid function tests should become part of the routine assessment of MS patients, in view of the inaccuracy currently observed in the assessment of clinical hypothyroidism as a result of the superposition of hypothyroidism and MS signs and symptoms.KEY WORDS: multiple sclerosis, antimicrosomal antibodies, hypothyroidism.A esclerose múltipla (EM) é doença desmielinizante que resulta de reações inflamatórias desencadeadas por mecanismos complexos de anormalidade imunorregulatória, provavelmente associados a fatores genéticos e ambientais. O mecanismo autoimune pode ser caracterizado pela presença de diversos auto-anticorpos contra antígenos circulantes órgão-específicos (tireóide, estômago, pâncreas) entre os quais os antimicrossomais (AAM) [1][2][3][4][5] . Os ...

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“…Ijdo et al [21] also detected high prevalence of APL, mainly of IgM class (88%) in MS patients. Roussel et al [22] suggest that despite anti-beta-2-glycoprotein I antibodies are found in 32% of the studied MS patients, they show no correlation with the disease manifestations and progression. Heinzief et al [23] found positive ACL in 15% of 285 MS patients, mainly of IgM class, and these antibodies showed no correlation with the disease manifestations and evolution.…”

Section: Introductionmentioning

confidence: 99%

Annexin V antibodies in multiple sclerosis and SLE/APS

et al. 2013

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AbstractMultiple sclerosis (MS) is an autoimmune disease with unclear etiopathogenesis. Some MS patients have anticardiolipin (ACL), anti-beta-2-glycoprotein-I (B2GPI) and anti-annexin V (AnV) antibodies. These antibodies can also be found in systemic lupus erythematosus with antiphospholipid syndrome (SLE/APS). The aim of our study was to compare the levels of ACL, B2GPI and AnV antibodies in MS and SLE/APS. Materials and methods: We investigated serum levels of IgG and IgM ACL, B2GPI and AnV in 21 MS patients, 30 SLE/APS patients and 30 controls using ELISA. Results: Mean levels of IgM and IgG ACL and B2GPI in MS were comparable with controls and lower than SLE/APS (p<0.05). Mean levels of IgM AnV in MS were higher compared to SLE/APS and controls (p<0.05); mean levels of IgG AnV in MS were higher than normal but similar to SLE/APS (p>0.05). Discussion: The results show that MS with negative “classic” autoantibodies (ACL and B2GPI) and without clinical data for antiphospholipid syndrome may have other positive antiphospholipid antibodies, such as AnV. Larger studies are needed to clarify whether AnV are epiphenomenon of the vascular and organ damage or they play a pathogenic role in the development of MS.

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Prevalence and Clinical Significance of Anti-phospholipid Antibodies in Multiple Sclerosis: a Study of 89 Patients

Cited by 63 publications

References 41 publications

Do we need broad immunological work-up in all patients with CIS?

Do we need broad immunological work-up in all patients with CIS?

Prevalência de anticorpos antimicrossomais em pacientes com esclerose múltipla

Annexin V antibodies in multiple sclerosis and SLE/APS

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