Scleredema diabeticorum – A case report

Abstract

Scleredema, a medical problem first described by Buschke in 1902, is a rare scleromatosis of unknown aetiology, which is characterized by wooden, nonpitting induration of the skin. This skin disorder first affects the neck and face and may symmetrically spread to the shoulders, trunk, arms, and legs. We report a case of a 65 year-old hypertensive and diabetic male who presented with marked thickening of the upper back with obvious peau d'orange changes. Association with other complications of diabetes is not certain and treatment is difficult, though improvement is possible with optimal glycaemic control. Scleredema diabeticorum is rare and is a cause of significant morbidity in diabetes. Ó 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

Treatment of scleredema adultorum of Buschke with intravenous immunoglobulin and mycophenolate mofetil in a 14-year-old girl: a case report

“…This type progresses slowly and is associated with paraproteinemias including multiple myeloma [ 4 , 5 ]. Type 3 is associated with diabetes mellitus and, similar to type 2, is slowly progressive and has a non-resolving course [ 6 ]. In our patient, skin thickness developed rapidly within 1 month and was not completely resolved after 5 years.…”

Scleredema diabeticorum – A case report

“…[ 1 ] In dermis, more collagen and mucin (hyaluronic acid, an acid mucopolysaccharide) is produced by fibroblasts, as there is irreversible glycosylation of collagen and alterations in collagenase activity. [ 1 2 6 7 ] Another pathogenesis approach reports that the microvascular damage and hypoxia have the primary role in the excessive genesis of collagen and mucin.…”

“…But the vast majority of reported patients have undergone systemic therapy with systemic steroids, methotrexate, cyclosporine, IVIg, and colchicine. [ 1 2 3 4 5 6 7 8 9 ] Physical therapy is recommended to increase range of motion. [ 10 ]…”

Post-streptococcal scleredema an unusual rare mimicker of scleroderma: a case report

“…n DISCUSSION Scleredema of Buschke is a rare skin condition that is characterized by thickening and hardening of the skin (6). It is typically caused by a streptococcal infection, such as strep throat or scarlet fever, and can occur in individuals of any age (7). The condition typically affects the neck, upper chest, and back, although it can also occur in the arms and legs.…”