Background Various factors contribute to the pathogenesis of a disease. These include genetic factors, family history, and some idiopathic causes. Genetic makeup has an important role in the progression of disease. This is due to mutations in genetic material, that is, deoxyribonucleic acid (DNA). Methodology This is a cross‐sectional study that involved 5000 participants distributed across 250 countries. All the participants were randomly selected and asked to fill out the online survey. All the participants were fully informed about the study's purpose before providing their consent. Results The participants were distributed among 250 countries. Their age mean (standard deviation) is 46.7 (12.4). We discovered a significant difference between those who have genetic or congenital diseases and those who have a family history of the disease. Also, there is a statistically significant difference between the recurrence of the disease and the duration of the visits of close relatives who have the same disease. Conclusion The study suggests that there might be some ways, through gene waves or the environment, in which a gene changes the expression of other genes of similar sequence in different individuals when the required period of contact is provided. In the future, this theory might explain the idiopathic nature of some diseases.

Uterine rupture mostly occurs in the third trimester. However, it may occur at an earlier time with the same catastrophic consequences. The authors present a case report of uterine rupture occurring in the second trimester at 18 weeks gestation.

This case report presents the first H‐syndrome rarity in Iraq, a 12‐year‐old female patient who was attending the Rheumatology out clinic for progressive hands joint deformities. She has a history of a multi‐systemic collection of diseases with various clinical features that include beta thalassemia minor, sensorineural deafness, and celiac disease.

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Rheumatoid arthritis is a systemic autoimmune disease with a peak incidence between the ages of 30 and 50 years old. Rheumatoid arthritis that first appears in people over the age of 60 is commonly referred to as "elderly onset Rheumatoid Arthritis." We present an extremely rare case of a 106-year-old female newly diagnosed with rheumatoid arthritis. By reporting this case, we hope to encourage medical professionals to concentrate on diagnosing old patients with unusual presentation of rheumatoid arthritis."Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting synovial tissue and leading to joint destruction and disability". 1 Approximately 0.3-1% of the world's population suffers from RA. 2 RA that first appears in people over the age of 60 is commonly referred to as "elderly onset Rheumatoid Arthritis". 3 Traditional estimates place the peak incidence of RA between the ages of 30 and 50; nevertheless, the number of late-60s onset cases has been rising in recent years. 4 Elderly-onset rheumatoid arthritis (EORA) differs from RA that presents before age 60 in a variety of ways, including the prevalence of males, the clinical presentation, the prognosis, the presence of co-morbid conditions, and the frequency with which an anti-cyclic citrullinated peptide antibody or rheumatoid factor is positive. 5,6 We present an extremely rare case of a 106-year-old female newly diagnosed with RA. | CASE PRESENTATIONA 106-year-old female presented with generalized bone pain, low-grade fever, and the inability to walk; she was previously able to walk alone in her home without an assistant. She went to a a general practitioner, who

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cleredema of Buschke is a rare pathological disorder of connective tissue, which is characterized by a woody, diffuse induration of the skin, most often in the upper extremities. We report an extremely rare complication of post-streptococcal infection in a six-year-old male complaining of gradually progressing, painless skin thickening and tightness which was preceded by a one-month history of fever, cough, and tonsillitis. By reporting this case, we hope to contribute to the creation of a database for future research aimed at better understanding the incidence, pathophysiology, and management of this extremely rare complication.