Scleredema and paraproteinemia. Enhanced collagen production and elevated type I procollagen messenger RNA level in fibroblasts grown from cultures from the fibrotic skin of a patient

Juvenile, insulin‐dependent diabetes mellitus, type 1‐related dermatoses

“…Histological confirmation by punch or incision biopsy is not systematically required. 70 The specific histological findings are represented by the thickness of the dermis caused by both enlarged collagen bundles and the presence of clear spaces or 'fenestrations' between them, filled with mucopolysaccharides. Mucin deposit is more likely to be observed in the deep dermis and can be stained with Alcian Blue dye.…”

UVA‐1 as a treatment for scleredema

“…UVA‐1 irradiation has been shown to induce collagenase in vitro and in vivo ,(2) and has been used successfully as a therapy in morphea(3). Studies have indicated an increased synthesis of collagen and elevated levels of collagen mRNA in scleredema (4, 5); therefore, it is reasonable to think that UVA‐1 therapy may be used as treatment of scleredema as well as scleroderma. Here we report two cases of scleredema that were successfully treated with UVA‐1.…”

Radiotherapy of Benign Diseases—Scleredema Adultorum Buschke

“…This process may extend into the subcutaneous fatty tissue. Abnormal expression of extracellular matrix genes in skin fibroblasts [34] as well as increased procollagen production in fibroblast cultures established from the lesional skin [26] have been observed. Serum samples from patients with dermal fibrosis and paraproteinemia stimulate the collagen synthesis in fibroblast cultures [25].…”