Juvenile, insulin‐dependent diabetes mellitus, type 1‐related dermatoses

Sehgal, Virendra; Bhattacharya, S N; Verma, Parul

doi:10.1111/j.1468-3083.2010.03912.x

Cited by 27 publications

(24 citation statements)

References 126 publications

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“…7 Other possibilities include antibody-mediated vasculitis, collagen abnormalities, platelet aggregation, trauma, inflammatory and metabolic changes or a tumour necrosis factor mediated process. 6,8 The finding of Glut 1 (human erythrocyte glucose transporter) expression in areas of sclerotic collagen suggest a possible role for abnormal glucose transport by fibroblasts. 1…”

Section: Aetiologymentioning

confidence: 99%

Necrobiosis lipoidica

George

Walton

2015

Br J Diabetes

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Necrobiosis lipoidica and granuloma annulare are granulomatous skin conditions that have been traditionally associated with diabetes mellitus, although recently the strength of association has been questioned. In the first section of this two-part article, we describe the suggested aetiology, clinical features, histology and treatment of necrobiosis lipoidica. It is found in 0.3% of patients with diabetes, but has also been reported with other systemic conditions. Clinically it appears as a waxy, atrophic, yellowish plaque with overlying telangiectasia and a brown border. Although usually asymptomatic, it may be extremely painful, especially if ulcerated. Squamous cell carcinoma has occasionally been reported with longstanding lesions. Treatment is often difficult: numerous topical and systemic agents have been employed, but evidence is limited to small case series and individual case reports. Br J Diabetes 2016;16:6-9

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Section: Aetiologymentioning

confidence: 99%

Necrobiosis lipoidica

George

Walton

2015

Br J Diabetes

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“…The etiology of NLD is still unknown. Microangiopathy, immune complex vasculitis with involvement of T cells, release of proinflammatory cytokines, and abnormal collagen production have all been implicated [11]. Several different therapies have been reported with limited success in the literature, including topical and systemic corticosteroids, nicotinamide, pentoxifylline, tretinoin, anti-TNF- α , mycophenolate mofetil, thalidomide, cyclosporine, tacrolimus, dipyridamole-aspirin, antimalarials, and PUVA [12–14].…”

Section: Discussionmentioning

confidence: 99%

Remission of Ulcerated Necrobiosis Lipoidica Diabeticorum after Bariatric Surgery

Bozkurt

Coşkun

Kadıoğlu

et al. 2013

Case Reports in Dermatological Medicine

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A 32-year-old woman with type 2 diabetes mellitus suffering from morbid obesity with BMI 45,14 kg/m2 was operated on. Not only the type 2DM but also one of its complication known as necrobiosis lipoidica diabeticorum remitted postoperatively. Obesity should no longer be regarded simply as a cosmetic problem affecting certain individuals but an epidemic that threatens global well-being. It causes or exacerbates many health problems, and in particular, it is associated with the type 2 diabetes. Necrobiosis lipoidica is a granulomatous skin disease of unknown etiology, associated mainly with diabetes mellitus. We presented in this paper a morbid obese case of necrobiosis lipoidica diabeticorum with dramatic good response to bariatric surgery.

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“…There are numerous medical consequences: blindness caused by diabetic retinopathy [11]; 21% to 40% of diabetic neuropathy cases [12,13]; up to 29% of occlusive arteriopathy cases of the lower limbs [14], not forgetting 50-70% of cases of skin conditions [15] and so on. Regarding professional consequences, diabetes can put a stop to a career in deep-sea diving.…”

Section: Discussionmentioning

confidence: 99%