Sciatic T‐cell neurolymphomatosis in a dog

Rupp, Angie; Ives, Edward; Rudorf, Heike; Constantino‐Casas, Fernando

doi:10.1136/vetreccr-2014-000050

Cited by 5 publications

(4 citation statements)

References 20 publications

(49 reference statements)

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“…Lymphoma is the main secondary tumor in the feline CNS and neurolymphomatosis is a rare condition in cats, other animals, and humans (Allen & Amis 1975, Hankenson et al 1998, Kuntzer et al 2000, Mellanby et al 2003, Higgins et al 2008, Choi et al 2013, Shree et al 2016. The neoplastic infiltration in leptomeninges (leptomeningeal lymphomatosis) and perivascular space from medullar parenchyma, as observed in the present study, is a common consequence relative to spinal nerve neurolymphomatosis (Lane et al 1994, Schaffer et al 2012, Mandrioli et al 2012, Rupp et al 2014, Sakurai et al 2016. The unusual feature of this condition can lead to confusion with other neurological conditions, such as vasculitis and mononeuritis (Mandrioli et al 2012).…”

Section: Discussionsupporting

confidence: 57%

Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats

et al. 2019

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ISSN 0100-736X (Print) ISSN 1678-5150 (Online) RESUMO.-[Linfoma no sistema nervoso de felinos: aspectos patológicos, imuno-histoquímicos e etiológicos em 16 gatos.] Os aspectos patológicos, imuno-histoquímicos (IHQ) e etiológicos do linfoma envolvendo o sistema nervoso de felinos foram analisados através de um estudo retrospectivo (período de 2004-2017) no Estado do Rio Grande do Sul, Brasil. O envolvimento do sistema nervoso foi observado em 16 (12,2%) dos 125 felinos com linfoma desse estudo e afetou principalmente, jovens com idade mediana de 24 meses. A grande maioria dos casos o linfoma era secundário no sistema nervoso central e somente em três gatos o linfoma foi primário do sistema nervoso. Na IHQ, 14 (87,5%) casos foram positivos para FeLV, seis (37,5%) para FIV, e um foi negativo para ambos. A distribuição do linfoma no sistema nervoso foi em 8/16 felinos na medula espinhal, 7/16 no encéfalo e em 1/16 em nervos e gânglios paravertebrais (neurolinfomatose). Na medula espinhal, o padrão do linfoma foi exclusivamente extradural e frequentemente focal (6/8), localizadas nos segmentos lombares (3/6), sacrais (1/6), torácicos (1/6) e cervicais (1/6). No encéfalo, os padrões neuroanatômicos observados foram: linfomatose leptomeningeal (4/7), coroidite linfomatosa (2/7), linfoma intradural (1/7). ABSTRACT.-Mello L.S., Leite-Filho R.V., Panziera W., Bandinelli M.B., Sonne L., Driemeier D. & Pavarini S.P. 2019. Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats. Pesquisa Veterinária Brasileira 39(6):393-401.

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Section: Discussionsupporting

confidence: 57%

Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats

et al. 2019

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“…This is particularly important in human medicine because paraneoplastic syndromes and chemotherapy toxicity are other causes of neuropathy (Antoine & Camdessanché, 2007). Cranial or spinal nerve involvement in lymphoma has been described in dogs, cats and horses, and the term neurolymphomatosis has been increasingly used (Hsueh et al, 2019; Lehmbecker et al, 2014; Mandrioli et al, 2012; Rupp et al, 2014; Sakurai et al, 2016; Schaffer et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…lymphoma has been described in dogs, cats and horses, and the term neurolymphomatosis has been increasingly used (Hsueh et al, 2019;Lehmbecker et al, 2014;Mandrioli et al, 2012;Rupp et al, 2014;Sakurai et al, 2016;Schaffer et al, 2012).…”

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confidence: 99%

Femoral B‐cell neurolymphomatosis in a horse with multicentric lymphoma

Bearth,

Donati,

Beckmann

et al. 2023

Equine Veterinary Education

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SummaryAn 18‐year‐old Freiberger gelding was presented with a history of intermittent left hindlimb lameness after an acute onset 2 weeks prior to referral. The lameness had not responded to anti‐inflammatory therapy prescribed by the referring veterinarian. Physical, orthopaedic and neurological examinations revealed signs compatible with ipsilateral femoral nerve dysfunction. Transrectal sonographic examination showed a marked increase in the diameter of the left femoral nerve. The results of electromyography of the left hind quadriceps muscle were compatible with denervation attributable to neuropathy. Evaluation of cerebral spinal fluid (CSF) revealed pleocytosis consisting of medium‐sized lymphocytes, 5%–10% of which were positive for CD3 and CD79a. Neoplasia was suspected and steroid therapy was started. However, exacerbation of the clinical signs occurred and the horse was euthanised. Histopathological evaluation showed neurolymphomatosis of the left femoral nerve as the cause of the lameness. Infiltration of tumour cells was also seen to a lesser extent in the right femoral nerve, spinal cord, various parts of the cardiovascular system, renal capsules, an abdominal lymph node and the subcutis of the left stifle and upper lip. Histochemical evaluation revealed 60%–70% of the neoplastic lymphocytes were positive for CD20 and CD79a and up to 40% were positive for CD3. This report describes the uniqueness of a femoral mononeuropathy as the main clinical finding of B‐cell neurolymphomatosis and multicentric lymphoma.

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“…Although lymphoma is one of the more common types of cardiac tumors, 19 nervous system involvement is rarely reported in canine lymphoma cases. 14,16,17,20 Neurolymphomatosis refers to a rare manifestation of lymphoma or leukemia involving neoplastic infiltration of peripheral nerves. 8 The clear involvement of the peripheral nervous system, but not the central nervous system, in our case is compatible with a diagnosis of neurolymphomatosis.…”

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confidence: 99%

CD3 and CD20 co-expression in a case of canine peripheral T-cell lymphoma with prominent cardiac and peripheral nerve involvement

et al. 2018

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An 8-y 9-mo-old male Pug dog was presented because of anorexia, hindlimb ataxia, vomiting, and progressive weight loss. Clinical examinations revealed atrophic hindlimb muscles with decreased postural reaction, enlargement of the cardiac silhouette and megaesophagus on radiograph, and reduced cardiac contractility on ultrasonography. The dog died 10 d after the initial examination, and an autopsy was performed. Grossly, the heart was enlarged, with multifocal-to-coalescing extensive plaque-like areas of discoloration on the epicardial surface. On cross-section, the ventricles were moderately dilated, and discoloration extended into the myocardium. Peripheral lymph nodes were of normal size. Histologically, atypical lymphoid cells replaced the myocardium and also extensively infiltrated peripheral nerve bundles in various organs. With immunohistochemistry, the neoplastic cells exhibited strong immunoreactivity for CD3 and CD20, and were negative for CD8, granzyme B, CD79α, and Pax5. Double-label immunofluorescence confirmed co-expression of CD3 and CD20 by the neoplastic cells. Molecular clonality analysis presented a clonal T-cell receptor gamma gene rearrangement. The case was diagnosed as a CD3+/CD20+ peripheral T-cell lymphoma with prominent cardiac and peripheral nerve involvement, indicating neurolymphomatosis.

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Sciatic T‐cell neurolymphomatosis in a dog

Cited by 5 publications

References 20 publications

Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats

Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats

Femoral B‐cell neurolymphomatosis in a horse with multicentric lymphoma

CD3 and CD20 co-expression in a case of canine peripheral T-cell lymphoma with prominent cardiac and peripheral nerve involvement

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