Schwangerschaftsberatung und Epilepsie

Rück, J.; Bauer, Jürgen

doi:10.1007/s00115-008-2443-0

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Geschlecht Frauen1

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2008

2015

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Cited by 4 publications

(1 citation statement)

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“…Möglicherweise profitieren in Bezug auf die Rate kindlicher Fehlbildungen insbesondere die hepatisch enzyminduzierenden Antiepileptika von der zunehmend konsequenteren Substitution mit Folsäure (beginnend mindestens 4 Wochen vor der Konzeption bis zum 2. Trimenon, meist in einer täglichen Dosierung von 5 mg/die empfohlen) [33]. Kontrazeptiva Die Wirkung hormoneller Kontrazeptiva (orale Kontrazeptiva, NUVA-Ring, Subkutanimplantat, intramuskuläre Applikation) kann durch AED gemindert werden.…”

Section: Geschlecht Frauenunclassified

Erstdiagnose Epilepsie – Wie ist das medikamentöse Vorgehen?

Bauer¹,

M²

2008

Fortschr Neurol Psychiatr

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Section: Geschlecht Frauenunclassified

Erstdiagnose Epilepsie – Wie ist das medikamentöse Vorgehen?

Bauer¹,

M²

2008

Fortschr Neurol Psychiatr

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Frauen mit Epilepsie: Befürchtungen, Wissen, Beratungsbedarf

May¹,

Pfäfflin²,

Coban³

et al. 2009

Nervenarzt

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Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function

et al. 2015

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Pregnancy needs complex pathways that together play a role in proper growth and protection of the fetus preventing its premature loss. Changes during pregnancy and postpartum period include the manifold machinery of neuroactive steroids that plays a crucial role in neuronal excitability by local modulation of specific inhibitory receptors: the GABAA receptors. Marked fluctuations in both blood and brain concentration of neuroactive steroids strongly contribute to GABAA receptor function and plasticity. In this review, we listed several interesting results regarding the regulation and plasticity of GABAA receptor function during pregnancy and postpartum period in rats. The increase in brain levels of neuroactive steroids during pregnancy and their sudden decrease immediately before delivery are causally related to changes in the expression/function of specific GABAA receptor subunits in the hippocampus. These data suggest that alterations in GABAA receptor expression and function may be related to neurological and psychiatric disorders associated with crucial periods in women. These findings could help to provide potential new treatments for these women's disabling syndromes.

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Schwangerschaftsberatung und Epilepsie

Abstract: Monotherapy with AED should be established if possible, and folic acid supplementation should be started prior to pregnancy.

Cited by 4 publications

References 20 publications

Erstdiagnose Epilepsie – Wie ist das medikamentöse Vorgehen?

Erstdiagnose Epilepsie – Wie ist das medikamentöse Vorgehen?

Frauen mit Epilepsie: Befürchtungen, Wissen, Beratungsbedarf

Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function

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