Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function

Licheri, Valentina; Talani, Giuseppe; Gorule, Ashish Avinash; Mostallino, Maria Cristina; Biggio, Giovanni; Sanna, Enrico

doi:10.1155/2015/170435

Cited by 28 publications

(18 citation statements)

References 78 publications

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“…Therefore, there is also interest in a potential role in postpartum depression. The role of GABA in pregnancy and the postpartum period has been nicely reviewed previously [169]. Relevant to postpartum depression, GABA levels have been shown to be inversely correlated with depression scores in women at risk for developing postpartum depression [163].…”

Section: Neurotransmitters and Postpartum Depressionmentioning

confidence: 99%

Pathophysiological mechanisms implicated in postpartum depression

Payne

Maguire

2019

Frontiers in Neuroendocrinology

258

171

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This review aims to summarize the diverse proposed pathophysiological mechanisms contributing to postpartum depression, highlighting both clinical and basic science research findings. The risk factors for developing postpartum depression are discussed, which may provide insight into potential neurobiological underpinnings. The evidence supporting a role for neuroendocrine changes, neuroinflammation, neurotransmitter alterations, circuit dysfunction, and the involvement of genetics and epigenetics in the pathophysiology of postpartum depression are discussed. This review integrates clinical and preclinical findings and highlights the diversity in the patient population, in which numerous pathophysiological changes may contribute to this disorder. Finally, we attempt to integrate these findings to understand how diverse neurobiological changes may contribute to a common pathological phenotype. This review is meant to serve as a comprehensive resource reviewing the proposed pathophysiological mechanisms underlying postpartum depression.

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Section: Neurotransmitters and Postpartum Depressionmentioning

confidence: 99%

Pathophysiological mechanisms implicated in postpartum depression

Payne

Maguire

2019

Frontiers in Neuroendocrinology

258

171

View full text Add to dashboard Cite

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“…Sudden estradiol withdrawal could lead to dysregulation in brain dopaminergic pathways and hence PPD. Multiple neuroendocrine changes caused by pregnancy may also play a role in PPD development, including dysfunctional gamma-aminobutyric acid (GABA) signaling ( 36 , 37 ). PPD has also been found to be associated with low allopregnanolone levels during pregnancy ( 38 ).…”

Section: Etiological Models Of Ppdmentioning

confidence: 99%

Postpartum Depression: Current Status and Possible Identification Using Biomarkers

Yu¹,

Hong²,

Chen

et al. 2021

Front. Psychiatry

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Postpartum depression (PPD) is a serious health issue that can affect about 15% of the female population within after giving birth. It often conveys significant negative consequences to the offsprings. The symptoms and risk factors are somewhat similar to those found in non-postpartum depression. The main difference resides in the fact that PPD is triggered by postpartum specific factors, including especially biological changes in the hormone levels. Patients are usually diagnosed using a questionnaire onsite or in a clinic. Treatment of PPD often involves psychotherapy and antidepressant medications. In recent years, there have been more researches on the identification of biological markers for PPD. In this review, we will focus on the current research status of PPD, with an emphasis on the recent progress made on the identification of PPD biomarkers.

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“…Given the ability of steroid hormones and neurosteroids to regulate GABA A Rs ( Abramian et al, 2014 ; Modgil et al, 2017 ), which occurs throughout the peripartum period ( Licheri et al, 2015 ), it is not surprising that alterations in GABAergic signaling has been implicated in the underlying neurobiology of PPD. In women at risk for developing PPD, GABA levels have been shown to be lower during the peripartum period ( Deligiannidis et al, 2016 ).…”

Section: Postpartum Depressionmentioning

confidence: 99%

Neuroactive Steroids and GABAergic Involvement in the Neuroendocrine Dysfunction Associated With Major Depressive Disorder and Postpartum Depression

Maguire

2019

Front. Cell. Neurosci.

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Stress and previous adverse life events are well-established risk factors for depression. Further, neuroendocrine disruptions are associated with both major depressive disorder (MDD) and postpartum depression (PPD). However, the mechanisms whereby stress contributes to the underlying neurobiology of depression remains poorly understood. The hypothalamic-pituitary-adrenal (HPA) axis, which mediates the body’s neuroendocrine response to stress, is tightly controlled by GABAergic signaling and there is accumulating evidence that GABAergic dysfunction contributes to the impact of stress on depression. GABAergic signaling plays a critical role in the neurobiological effects of stress, not only by tightly controlling the activity of the HPA axis, but also mediating stress effects in stress-related brain regions. Deficits in neuroactive steroids and neurosteroids, some of which are positive allosteric modulators of GABAA receptors (GABAARs), such as allopregnanolone and THDOC, have also been implicated in MDD and PPD, further supporting a role for GABAergic signaling in depression. Alterations in neurosteroid levels and GABAergic signaling are implicated as potential contributing factors to neuroendocrine dysfunction and vulnerability to MDD and PPD. Further, potential novel treatment strategies targeting these proposed underlying neurobiological mechanisms are discussed. The evidence summarized in the current review supports the notion that MDD and PPD are stress-related psychiatric disorders involving neurosteroids and GABAergic dysfunction.

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Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function

Cited by 28 publications

References 78 publications

Pathophysiological mechanisms implicated in postpartum depression

Pathophysiological mechanisms implicated in postpartum depression

Postpartum Depression: Current Status and Possible Identification Using Biomarkers

Neuroactive Steroids and GABAergic Involvement in the Neuroendocrine Dysfunction Associated With Major Depressive Disorder and Postpartum Depression

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