Schizophrenic micellization of poly(ethylene oxide-b-methacrylic acid) induced by phosphate and calcium ions

Guragain, Sudhina; Bastakoti, Bishnu Prasad; Nakashima, Kenichi

doi:10.1016/j.jcis.2010.06.007

Cited by 21 publications

(19 citation statements)

References 34 publications

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“…It has been found that some of the stimuli-responsive polymeric micelles of poly (N-isopropylacrylamide) and poly (acrylic acid) blocks show schizophrenic behavior. Here, the schizophrenic behavior means that some AB-type diblock copolymers can create two different micelle structures, for example, the A-core/B-corona arrangement and B-core/A-corona arrangement, and the two structures can be reversibly converted to each other by some stimuli [ 41–44 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of sharply thermo and PH responsive PMA-b-PNIPAM-b-PEG-b-PNIPAM-b-PMA by RAFT radical polymerization and its schizophrenic micellization in aqueous solutions

Ahmadkhani

Abbasian

Akbarzadeh

2017

Designed Monomers and Polymers

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Sharply thermo- and pH-responsive pentablock terpolymer with a core-shell-corona structure was prepared by RAFT polymerization of N-isopropylacrylamide and methacrylic acid monomers using PEG-based benzoate-type of RAFT agent. The PEG-based RAFT agent could be easily synthesized by dihydroxyl-capped PEG with 4-cyano-4-(thiobenzoyl) sulfanylpentanoic acids, using esterification reaction. This pentablock terpolymer was characterized by 1H NMR, FT-IR, and GPC. The PDI was obtained by GPC, indicating that the molecular weight distribution was narrow and the polymerization was well controlled. The thermo- and pH-responsive micellization of the pentablock terpolymer in aqueous solution was investigated using ﬂuorescence spectroscopy technique, UV–vis transmittance, and TEM. The LCST of pentablock terpolymer increased (over 50 °C) compared to the NIPAM homopolymer (~32 °C), due to the incorporation of the hydrophilic PEG and PMA blocks in pentablock terpolymer (PNIPAM block as the core, PEG the block and the hydrophilic PMA block as the shell and the corona). Also, pH-dependent phase transition behavior shows at a pH value of about ~5.8, according to pKa of MAA. Thus, in acidic solution at room temperature, the pentablock terpolymer self-assembled to form core–shell–corona micelles, with the hydrophobic PMA block as the core, the PNIPAM block and the hydrophilic PEG block as the shell and the corona, respectively.

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Section: Introductionmentioning

confidence: 99%

Synthesis of sharply thermo and PH responsive PMA-b-PNIPAM-b-PEG-b-PNIPAM-b-PMA by RAFT radical polymerization and its schizophrenic micellization in aqueous solutions

Ahmadkhani

Abbasian

Akbarzadeh

2017

Designed Monomers and Polymers

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“…As the molar ratios of H 3 PO 4 and TEOS were varied from 2:1 (Sample A) to 3:1 (Sample B) and 5:1 (Sample C), the local ordering of mesopores was destroyed and, therefore, the optimized molar ratio of H 3 PO 4 and TEOS in the present study was 2:1 (Sample A). It has been already reported that the water‐soluble PEO unit becomes insoluble at higher PO 4 3− concentrations 23. Thus, the insolubility of PEO unit cannot work well to preserve the micelle structure and finally causes the deformation of the mesoporous structure of phosphosilicate films, as seen in SEM images (Figure S2 in the Supporting Information).…”

Section: Resultsmentioning

confidence: 93%

Synthesis of a Large‐Sized Mesoporous Phosphosilicate Thin Film through Evaporation‐Induced Polymeric Micelle Assembly

Bastakoti

Imura

et al. 2014

Chemistry An Asian Journal

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A triblock copolymer, poly(styrene-b-2-vinyl pyridine-b-ethylene oxide) (PS-b-P2VP-b-PEO) was used as a soft template to synthesize large-sized mesoporous phosphosilicate thin films. The kinetically frozen PS core stabilizes the micelles. The strong interaction of the inorganic precursors with the P2VP shell enables the fabrication of highly robust walls of phosphosilicate and the PEO helps orderly packing of the micelles during solvent evaporation. The molar ratio of phosphoric acid and tetraethyl orthosilicate is crucial to achieve the final mesostructure. The insertion of phosphorus species into the siloxane network is studied by (29) Si and (31) P MAS NMR spectra. The mesoporous phosphosilicate films exhibit steady cell adhesion properties and show great promise as excellent materials in bone-growth engineering applications.

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“…Our group has reported a number of studies on schizophrenic micellization of DHBCs employing various stimuli 99–103. One of them employed temperature and metal ions to induce schizophrenic micellization of PAMPS‐ b ‐PNIPAM.…”

Section: Schizophrenic Micellesmentioning

confidence: 99%

Multi‐Stimuli‐Responsive Polymeric Materials

Guragain

Bastakoti

Malgras

et al. 2015

Chemistry A European J

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195

114

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Stimuli-responsive materials are of immense importance because of their ability to undergo alteration of their properties in response to their environment. The properties of such materials can be tuned by subtle adjustments in temperature, pH, light, and so forth. Among such smart materials, multi-stimuli-responsive polymeric materials are of pronounced significance as they offer a wide range of applications and their properties can be tuned through several mechanisms. Here, we aim to highlight some recent studies showcasing the multi-stimuli-responsive character of these polymers, which are still relatively little known compared to their single-stimuli-responsive counterpart.

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Schizophrenic micellization of poly(ethylene oxide-b-methacrylic acid) induced by phosphate and calcium ions

Cited by 21 publications

References 34 publications

Synthesis of sharply thermo and PH responsive PMA-b-PNIPAM-b-PEG-b-PNIPAM-b-PMA by RAFT radical polymerization and its schizophrenic micellization in aqueous solutions

Synthesis of sharply thermo and PH responsive PMA-b-PNIPAM-b-PEG-b-PNIPAM-b-PMA by RAFT radical polymerization and its schizophrenic micellization in aqueous solutions

Synthesis of a Large‐Sized Mesoporous Phosphosilicate Thin Film through Evaporation‐Induced Polymeric Micelle Assembly

Multi‐Stimuli‐Responsive Polymeric Materials

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