Synthesis of a Large‐Sized Mesoporous Phosphosilicate Thin Film through Evaporation‐Induced Polymeric Micelle Assembly

Abstract

A triblock copolymer, poly(styrene-b-2-vinyl pyridine-b-ethylene oxide) (PS-b-P2VP-b-PEO) was used as a soft template to synthesize large-sized mesoporous phosphosilicate thin films. The kinetically frozen PS core stabilizes the micelles. The strong interaction of the inorganic precursors with the P2VP shell enables the fabrication of highly robust walls of phosphosilicate and the PEO helps orderly packing of the micelles during solvent evaporation. The molar ratio of phosphoric acid and tetraethyl orthosilicate is crucial to achieve the final mesostructure. The insertion of phosphorus species into the siloxane network is studied by (29) Si and (31) P MAS NMR spectra. The mesoporous phosphosilicate films exhibit steady cell adhesion properties and show great promise as excellent materials in bone-growth engineering applications.

Smart Soft‐Templating Synthesis of Hollow Mesoporous Bioactive Glass Spheres

“…Considering the influence of structural and textural features on bone‐tissue‐engineering application, mesoporous materials are the most suitable candidates due to their unique assets, such as high surface area, large pore volume, and controllable pore size 2. Mesoporous materials provide an appropriate scaffold for the adhesion and proliferation of bone cells, and also allow ions for easy dissolution and diffusion into the environment to accelerate the rate of formation of hydroxyapatite (HA) after immersion into simulated body fluid (SBF) 3–5. Moreover, a large amount of drug molecules and active agents are loaded into the mesopores and can be used as drug‐delivery system for bone regeneration.…”

“…They are reacted each other to form a gel at room temperature and subsequently calcined at high temperature to form the final BG 2. Different morphologies of mesoporous bioactive glass (MBG) including spheres, monoliths, and films have already been reported 3. 7–9 Commonly, the diameter of MBG spheres is several micrometers, which is improper size for phagocytosis when they are used as drug carriers.…”

“…[2] Mesoporousm aterials provide an appropriate scaffold for the adhesion andp roliferation of bone cells, and also allow ions for easy dissolution and diffusion into the environment to accelerate the rate of formation of hydroxyapatite( HA) after immersion into simulated body fluid (SBF). [3][4][5] Moreover,alarge amount of drug molecules and active agents are loaded into the mesopores and can be used as drug-delivery system for bone regeneration.Sol-gel methodi sm ostly used route compared with traditional melt-quenching for the synthesis of BG. [6] As at ypical example,t etraethyl orthosilicate (TEOS), triethylphosphate (TEP), and calcium nitrate (Ca(NO 3 ) 2 )a re used as startingp recursors.…”

“…[2] Different morphologies of mesoporous bioactive glass (MBG) including spheres, monoliths, and films have already been reported. [3,[7][8][9] Commonly,t he diameter of MBG spheres is severalm icrometers, which is improper size for phagocytosis when they are used as drugc arriers. For example, Wu and co-workers reported easy synthesis of MBG nanospheres,b yu sing cetyltrimethylammonium bromide (CTAB) and poly(vinylpyrrolidone) (PVP) as templates, which were promising materials for drug carriers.…”

Asymmetric Block Copolymers for Supramolecular Templating of Inorganic Nanospace Materials

“…We have introduced a “polymeric micelle assembly approach” to prepare mesoporous materials and the schematic illustration for the preparation of mesoporous metal oxides is shown in Figure . Asymmetric triblock copolymers are micellized and stabilized as porogens, and then the micelles are assembled with inorganic precursors and removed by calcination.…”