Schistosoma mansoni: In vitro schistosomicidal activity of essential oil of Baccharis trimera (less) DC

Oliveira, Rosimeire Nunes de; Rehder, Vera Lúcia Garcia; Oliveira, Adriana Silva Santos; Júnior, Ílio Montanari; Carvalho, João Ernesto de; Ruiz, Ana Lúcia Tasca Góis; Jeraldo, Verónica de Lourdes Sierpe; Linhares, Arício Xavier; Allegretti, Silmara Marques

doi:10.1016/j.exppara.2012.06.005

Cited by 81 publications

(82 citation statements)

References 43 publications

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“…Being a part of the Asteraceae family [21,22], B. trimera has numerous pharmacological activities popularly attributed to their leaves, such as antiinflammatory, digestive [23], antioxidant [24], antiulcer [23,25], and antimicrobial [19,20] properties that can be helpful in the treatment of diabetes [26], rheumatism, and hepatobiliary disorders [27]. Therefore, the aim of this study was to investigate the in vitro antifungal activity of the essential oil of B. trimera against the main strains of filamentous fungi that cause onychomycosis.…”

Section: Introductionmentioning

confidence: 99%

In vitro Antifungal Activity of Baccharis trimera Less (DC) Essential Oil against Dermatophytes

Caneschi¹,

Martins²,

Larrudé³

et al. 2015

Trop. J. Pharm Res

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Section: Introductionmentioning

confidence: 99%

In vitro Antifungal Activity of Baccharis trimera Less (DC) Essential Oil against Dermatophytes

Caneschi¹,

Martins²,

Larrudé³

et al. 2015

Trop. J. Pharm Res

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“…Hence, the massive use of PZQ in zones of endemicity with the possibility of the emergence of drug-resistant Schistosoma, combined with the lack of any other effective antischistosomal drug, requires new effective schistosomicidal compounds to be developed and further studies to be carried out with a view to developing alternative therapies that could either replace or complement the use of PZQ for treatment of S. mansoni infection (4,13).…”

mentioning

confidence: 99%

“…This parasitic disease ranks second after malaria in terms of its public health importance and has a significant economic and social impact. It is estimated that more than 207 million people have been infected worldwide, while 779 million people remain at risk of infection (1)(2)(3)(4)(5)(6).…”

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confidence: 99%

Evaluation of the Anti-Schistosoma mansoni Activity of Thiosemicarbazones and Thiazoles

Santiago

Oliveira

Filho

et al. 2014

Antimicrob Agents Chemother

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f Schistosomiasis is a chronic and debilitating disease caused by a trematode of the genus Schistosoma and affects over 207 million people. Chemotherapy is the only immediate recourse for minimizing the prevalence of this disease and involves predominately the administration of a single drug, praziquantel (PZQ). Although PZQ has proven efficacy, there is a recognized need to develop new drugs as schistosomicides since studies have shown that repeated use of this drug in areas of endemicity may cause a temporary reduction in susceptibility in isolates of Schistosoma mansoni. Hydrazones, thiosemicarbazones, phthalimides, and thiazoles are thus regarded as privileged structures used for a broad spectrum of activities and are potential candidates for sources of new drug prototypes. The present study determined the in vitro schistosomicidal activity of 10 molecules containing these structures. During the assays, parameters such motility and mortality, oviposition, morphological changes in the tegument, cytotoxicity, and immunomodulatory activity caused by these compounds were evaluated. The results showed that compounds formed of thiazole and phthalimide led to higher mortality of worms, with a significant decline in motility, inhibition of pairing and oviposition, and a mortality rate of 100% starting from 144 h of exposure. These compounds also stimulated the production of nitric oxide and tumor necrosis factor alpha (TNF-␣), thereby demonstrating the presence of immunomodulatory activity. The phthalyl thiazole LpQM-45 caused significant ultrastructural alterations, with destruction of the tegument in both male and female worms. According to the present study, phthalyl thiazole compounds possess antischistosomal activities and should form the basis for future experimental and clinical trials.

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“…The results of the present study showed that the susceptibility of male and female worms to venom varied, with male worms being more susceptible than females were. In this regard, male S. mansoni worms were also more susceptible than females were to praziquantel, ginger extract, diamines, and amino alcohols and to treatment with certain essential oils (35) (36) (37) (38) (39) . However, there was no differential sensitivity to piplartine between male and female worms in vitro (34) .…”

Section: Discussionmentioning

confidence: 99%

In vitro antischistosomal activity of venom from the Egyptian snake Cerastes cerastes

Hassan

Abdel-Rahman

Ibrahim

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:We studied the potential in vitro antischistosomal activity of Cerastes cerastes venom on adult Schistosoma mansoni worms. Methods: Live specimens of the horned viper snake, C. cerastes were collected from the Aswan Governorate (Egypt). Venom was collected from snakes by manual milking. Worms of S. mansoni were obtained from infected hamsters by perfusion and isolated from blood using phosphate buffer. Mortality rates of worms were monitored after 3 days of exposure to snake venom at LC 50 and various sublethal concentrations (10, 5, 2.5µg/ml). Scanning electron microscopy was used to investigate tegumental changes in treated worms after exposure to LC 50 doses of venom. Results: The LC 50 of C. cerastes venom was 21.5µg/ml. The effect of C. cerastes venom on Schistosoma worms varied according to their sex. The mortality rate of male and female worms after 48-h exposure was 83.3% and 50% , respectively. LC 50 of C. cerastes venom induced mild to severe tegumental damage in Schistosoma worms in the form of destruction of the oral sucker, shrinkage and erosion of the tegument, and loss of some tubercle spines. Conclusions: The present study demonstrated that C. cerastes venom exerts potential in vitro antischistosomal activity in a time and dose-dependent manner. These results may warrant further investigations to develop novel schistosomicidal agents from C. cerastes snake venom.

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Schistosoma mansoni: In vitro schistosomicidal activity of essential oil of Baccharis trimera (less) DC

Cited by 81 publications

References 43 publications

<i>In vitro</i> Antifungal Activity of <i>Baccharis trimera</i> Less (DC) Essential Oil against Dermatophytes

<i>In vitro</i> Antifungal Activity of <i>Baccharis trimera</i> Less (DC) Essential Oil against Dermatophytes

Evaluation of the Anti-Schistosoma mansoni Activity of Thiosemicarbazones and Thiazoles

In vitro antischistosomal activity of venom from the Egyptian snake Cerastes cerastes

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