&lt;i&gt;In vitro&lt;/i&gt; Antifungal Activity of &lt;i&gt;Baccharis trimera&lt;/i&gt; Less (DC) Essential Oil against Dermatophytes

Caneschi, CA; Martins, Francislene Juliana; Larrudé, DG; Romani, EC; Brandão, M. A. F.; Raposo, Nádia Rezende Barbosa

doi:10.4314/tjpr.v14i11.19

Cited by 22 publications

(12 citation statements)

References 32 publications

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“…We identified a new partial sequence in the ITS region from the T. mentagrophytes ATCC 11481-NCBI/GenBank KX132909 complex due to the difficulties of identifying different species using only phenotypic characteristics, as reported previously by Packeu et al (2013). 43 Moreover, this procedure was not necessary for other strains used herein because these standard strains have been investigated recently by different authors, 18 , 34 , 44 , 45 confirming the characterization of the strains.…”

Section: Discussionsupporting

confidence: 56%

“…Moreover, this procedure was not necessary for other strains used herein because these standard strains have been investigated recently by different authors,18, 34, 44, 45 confirming the characterization of the strains.…”

Section: Discussionmentioning

confidence: 60%

“…Despite recent advances in medicine, treating onychomycosis remains challenging due to the anatomical characteristics of nails and the poor efficacy of currently available treatments. 1 , 18 , 19 , 20 Existing therapies for onychomycosis are only partially effective, and recurrence and consequent fungal resistance are common when combined with poor medication compliance. 21 , 22 , 23 , 24 , 25 Furthermore, oral antifungal drugs are associated with undesirable side effects, such as hepatotoxicity.…”

Section: Introductionmentioning

confidence: 99%

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In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis

Caneschi

Almeida

Martins

et al. 2017

Brazilian Journal of Microbiology

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Onychomycosis is a fungal infection of the nail caused by high densities of filamentous fungi and yeasts. Treatment for this illness is long-term, and recurrences are frequently detected. This study evaluated in vitro antifungal activities of 12 organic compounds derived from amino alcohols against standard fungal strains, such as Trichophyton rubrum CCT 5507 URM 1666, Trichophyton mentagrophytes ATCC 11481, and Candida albicans ATCC 10231. The antifungal compounds were synthesized from p-hydroxybenzaldehyde (4a–4f) and p-hydroxybenzoic acid (9a–9f). Minimum inhibitory concentrations and minimum fungicidal concentrations were determined according to Clinical and Laboratory Standards Institute protocols M38-A2, M27-A3, and M27-S4. The amine series 4b–4e, mainly 4c and 4e compounds, were effective against filamentous fungi and yeast (MIC from 7.8 to 312 μg/mL). On the other hand, the amide series (9a–9f) did not present inhibitory effect against fungi, except amide 9c, which demonstrated activity only against C. albicans. This allowed us to infer that the presence of amine group and intermediate carbon number (8C–11C) in its aliphatic side chain seems to be important for antifungal activity. Although these compounds present cytotoxic activity on macrophages J774, our results suggest that these aromatic compounds might constitute potential as leader molecules in the development of more effective and less toxic analogs that could have considerable implications for future therapies of onychomycosis.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

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In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis

Caneschi

Almeida

Martins

et al. 2017

Brazilian Journal of Microbiology

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“…In Brazil, there are about 180 Baccharis species that are predominantly found in Southeastern and Southern regions and are commonly used in folk medicine for treatment of headaches, diabetes symptoms, skin ulcerations and hepatobiliary disorders. [15] However, until now there are no reports on characterization and evaluation of biological applications for leaves of B. oreophila. [11][12][13] Among the Baccharis species, which already were chemically studied and were verified regard the antimicrobial and antioxidant potentials, stand out B. parvidentata MALAG., [5] B. psiadioides LESS., [11] B. aracatubaensis MALAG., B. burchellii BAKER, B. organensis BAKER, [13] B. uncinella DC.…”

Section: Introductionmentioning

confidence: 99%

“…DC. [15] However, until now there are no reports on characterization and evaluation of biological applications for leaves of B. oreophila.…”

Section: Introductionmentioning

confidence: 99%

Chemical Characterization, Antioxidant Capacity and Antimicrobial Potential of Essential Oil from the Leaves of Baccharis oreophilaMalme

Oliveira

Maia

Ferriani

et al. 2019

Chemistry & Biodiversity

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This is the first time that composition, antimicrobial potential and antioxidant ability of essential oil from the leaves of Baccharis oreophila are reported. Essential oil was obtained by hydrodistillation and analyzed by GC/MS. Antimicrobial potential was evaluated by diffusion disk and broth microdilution methods. ABTS * + , DPPH * and FRAP methods were employed for antioxidant activity evaluation. Essential oil yield was 0.47 %. Sixty-five compounds were identified, representing 88.53 % of the total essential oil, which showed to be rich in oxygenated (37.88 %) and hydrocarbons sesquiterpenes (34.84 %). The main constituents were khusimone (16.37 %) and spathulenol (16.12 %). Antimicrobial activity was verified against S. aureus (10.33 � 0.5 mm, MIC: 1250 μg mL À 1 ) and C. albicans (8.66 � 0.5 mm, MIC: > 2500 μg mL *1 ). Antioxidant ability was evidenced by FRAP (4.09 μmol FeSO 4 E mL À 1 ), ABTS * + (1.45 μmol TE mL À 1 ) and DPPH * (1.04 μmol TE mL À 1 ) scavenging capacity. Results showed that this essential oil has interesting biological potential, encouraging further investigations especially in relation to action mechanisms of antimicrobial and antioxidant activity.

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Volatile Organic Compounds and Their Capacity for Controlling Fungal Infection in Humans

Achimón

Merlo

Pizzolitto

et al. 2022

Promising Antimicrobials From Natural Products

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<i>In vitro</i> Antifungal Activity of <i>Baccharis trimera</i> Less (DC) Essential Oil against Dermatophytes

Abstract: Purpose: To identify the main components of the essential oil (EO) of Baccharis trimera Less and investigate their in vitro antifungal

Cited by 22 publications

References 32 publications

In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis

In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis

Chemical Characterization, Antioxidant Capacity and Antimicrobial Potential of Essential Oil from the Leaves of Baccharis oreophilaMalme

Volatile Organic Compounds and Their Capacity for Controlling Fungal Infection in Humans

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