Scenarios for 3D printing of personalized medicines - A case study

Beer, Netta; Hegger, Ingrid; Kaae, Susanne; Bruin, Marie L. De; Genina, Natalja; Alves, Teresa Leonardo; Hoebert, Joëlle M.; Sporrong, Sofia Kälvemark

doi:10.1016/j.rcsop.2021.100073

Cited by 35 publications

(39 citation statements)

References 26 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Such settings for the installation of 3D printers include in the patient’s house, in the pharmaceutical industry, in the community pharmacy, or in the hospital pharmacy. Beer et al published a detailed case study on the different theoretical scenarios mentioned here, where participants from various backgrounds related to the healthcare system were interviewed, sharing their perspective on the future of 3D printing as a manufacturing method for personalized treatments [ 53 ].…”

Section: Future Settings Of 3d-printed Pharmaceuticals and Challengesmentioning

confidence: 99%

“…This is especially worrying for pediatric dosage forms, where higher precision and safety should be achieved in all cases [ 55 ]. Additionally, another problem mentioned is the possible unintentional or intentional misuse of the home-produced drugs if no control is instituted [ 53 , 56 ]. Although involving patients in the process of their treatment has been proven to be beneficial for the outcome of treatment, meticulous training of the patients or the person taking care of them on the printing technology and assessment of the final product seems impractical [ 14 ].…”

Section: Future Settings Of 3d-printed Pharmaceuticals and Challengesmentioning

confidence: 99%

“…Nevertheless, there is the possibility of remote control of the printing process by specialists and medical staff [ 56 ], as there is always the chance that patients do not show an interest in participating in their treatment plan [ 54 ]. However, this setting is still considered the least realistic by healthcare professionals [ 53 ].…”

Section: Future Settings Of 3d-printed Pharmaceuticals and Challengesmentioning

confidence: 99%

See 2 more Smart Citations

The Advent of a New Era in Digital Healthcare: A Role for 3D Printing Technologies in Drug Manufacturing?

et al. 2022

View full text Add to dashboard Cite

The technological revolution has physically affected all manufacturing domains, at the gateway of the fourth industrial revolution. Three-dimensional (3D) printing has already shown its potential in this new reality, exhibiting remarkable applications in the production of drug delivery systems. As part of this concept, personalization of the dosage form by means of individualized drug dose or improved formulation functionalities has concentrated global research efforts. Beyond the manufacturing level, significant parameters must be considered to promote the real-time manufacturing of pharmaceutical products in distributed areas. The majority of current research activities is focused on formulating 3D-printed drug delivery systems while showcasing different scenarios of installing 3D printers in patients’ houses, hospitals, and community pharmacies, as well as in pharmaceutical industries. Such research presents an array of parameters that must be considered to integrate 3D printing in a future healthcare system, with special focus on regulatory issues, drug shortages, quality assurance of the product, and acceptability of these scenarios by healthcare professionals and public parties. The objective of this review is to critically present the spectrum of possible scenarios of 3D printing implementation in future healthcare and to discuss the inevitable issues that must be addressed.

show abstract

Section: Future Settings Of 3d-printed Pharmaceuticals and Challengesmentioning

confidence: 99%

Section: Future Settings Of 3d-printed Pharmaceuticals and Challengesmentioning

confidence: 99%

Section: Future Settings Of 3d-printed Pharmaceuticals and Challengesmentioning

confidence: 99%

See 1 more Smart Citation

The Advent of a New Era in Digital Healthcare: A Role for 3D Printing Technologies in Drug Manufacturing?

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The stability of intermediate products should be sufficient. Pharmacists should be able to store the intermediate products for an adequate amount of time before dosage form production to be cost-effective [77].…”

Section: Discussionmentioning

confidence: 99%

3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review

et al. 2022

View full text Add to dashboard Cite

3D printing of pediatric-centered drug formulations can provide suitable alternatives to current treatment options, though further research is still warranted for successful clinical implementation of these innovative drug products. Extensive research has been conducted on the compliance of 3D-printed drug products to a pediatric quality target product profile. The 3D-printed tablets were of particular interest in providing superior dosing and release profile similarity compared to conventional drug manipulation and compounding methods, such as oral liquids. In the future, acceptance of 3D-printed tablets in the pediatric patient population might be better than current treatments due to improved palatability. Further research should focus on expanding clinical knowledge, providing regulatory guidance and expansion of the product range, including dosage form possibilities. Moreover, it should enable the use of diverse good manufacturing practice (GMP)-ready 3D printing techniques for the production of various drug products for the pediatric patient population.

show abstract

“…This strategy combines the use of many 3D printers in the same room, producing the same product with control of the production [188]. On the other hand, the on-demand manufacture of pharmaceuticals at pharmacies, hospitals and health services still needs many discussion rounds regarding some ethical, stability and quality control concerns [189,190]. Even so, as discussed here, printing parameters (e.g., shape, size, pores) can affect the performance of 3D printed products, hence it is fundamental that an assay is capable of predicting drug content and performance of these products [191].…”

Section: Regulation Safety Considerations and Perspectivesmentioning

confidence: 99%

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

et al. 2021

View full text Add to dashboard Cite

3D printing has been widely used for the personalization of therapies and on-demand production of complex pharmaceutical forms. Recently, 3D printing has been explored as a tool for the development of topical dosage forms and wound dressings. Thus, this review aims to present advances related to the use of 3D printing for the development of pharmaceutical and biomedical products for topical skin applications, covering plain dressing and products for the delivery of active ingredients to the skin. Based on the data acquired, the important growth in the number of publications over the last years confirms its interest. The semisolid extrusion technique has been the most reported one, probably because it allows the use of a broad range of polymers, creating the most diverse therapeutic approaches. 3D printing has been an excellent field for customizing dressings, according to individual needs. Studies discussed here imply the use of metals, nanoparticles, drugs, natural compounds and proteins and peptides for the treatment of wound healing, acne, pain relief, and anti-wrinkle, among others. The confluence of 3D printing and topical applications has undeniable advantages, and we would like to encourage the research groups to explore this field to improve the patient’s life quality, adherence and treatment efficacy.

show abstract

Scenarios for 3D printing of personalized medicines - A case study

Cited by 35 publications

References 26 publications

The Advent of a New Era in Digital Healthcare: A Role for 3D Printing Technologies in Drug Manufacturing?

The Advent of a New Era in Digital Healthcare: A Role for 3D Printing Technologies in Drug Manufacturing?

3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

Contact Info

Product

Resources

About