SCC-Antigen: ein sensitiver und spezifischer Tumormarker für Plattenepithelkarzinome?

Fischbach, Wolfgang; Rink, Christian

doi:10.1055/s-2008-1067632

Cited by 15 publications

(2 citation statements)

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“…Tj/T 2 und dem Mangel an Spezifität eingeschränkt. So finden sich erhöhte Antigenkonzentrationen auch bei 7-16% der präinvasiven Zervixneoplasien (2,3,17,21,22) und bei nicht-malignen internistischen Krankheiten, beispielsweise bei 7-9% der Leberfunktionsstörungen, bei 4-11% der entzündlichen Lungenerkrankungen und bei 53% der Patienten mit Nierenfunktionsstörungen (4,5,14 Sorgfältige prospektive Folgeuntersuchungen und insbesondere der Einsatz des SCC-Antigens in der klinischen Routine neben dem bisher schon gebräuchlichen CEA werden zeigen, inwieweit der Marker diesen Ansprüchen gerecht werden kann.…”

Section: Diskussionunclassified

Bedeutung des SCC-Antigens in der Diagnostik und Verlaufskontrolle des Zervixkarzinoms: Eine kooperative Studie der Gynäkologischen Tumor-Marker-Gruppe (GTMG)

Crombach¹,

Würz²,

Herrmann³

et al. 2008

Dtsch med Wochenschr

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SCC (squamous cell carcinoma) antigen is a subfraction of tumour antigen TA-4 isolated from cervical squamous cell carcinomas. Serum concentrations of SCC antigen were measured by radioimmunoassay in 382 control subjects, 70 women with cervical intraepithelial neoplasia (CIN), 517 with cervical carcinoma and 203 with other gynaecological carcinomas. Elevated SCC antigen levels (greater than 2.5 ng/ml) were found in 4% of normal controls, in 7% of women with CIN I-III, in 2%-23% with various forms of genital adenocarcinomas, in 55% with primary and in 76% of those with recurrent cervical squamous cell carcinoma. The positivity rate of the antigen was correlated with tumour stage (FIGO) and lymph node involvement of primary cervical squamous cell carcinomas. During long-term follow-up serum levels of SCC antigen were found to be concordant with tumour activity in 74% of cases. Patients with still elevated marker levels after therapy had twice the recurrence rate of women with normal serum values. Routine determination of SCC antigen during follow-up of cervical cancer is recommended.

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Section: Diskussionunclassified

Bedeutung des SCC-Antigens in der Diagnostik und Verlaufskontrolle des Zervixkarzinoms: Eine kooperative Studie der Gynäkologischen Tumor-Marker-Gruppe (GTMG)

Crombach¹,

Würz²,

Herrmann³

et al. 2008

Dtsch med Wochenschr

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“…Diese Ergebnisse müssen allerdings noch an einer größeren Zahl von Patienten bestätigt werden. Zu berücksichtigen ist, daß Nierenfunktionsstörungen zu falsch hohen SCC-Konzentrationen führen können (16).…”

Section: Squamous-cell-carcinoma-antigenunclassified

Tumormarker bei der Diagnostik und Verlaufsbeurteilung von Bronchialkarzinomen

Fischbach¹

2008

Dtsch med Wochenschr

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Squamous cell carcinoma antigen in the diagnosis and treatment follow-up of oral and facial squamous cell carcinoma

Fischbach

Meyer

Barthel

1990

Cancer

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The squamous cell carcinoma (SCC) antigen was determined by radioimmunoassay in the serum of 40 untreated patients with SCC of the oromaxillofacial region. The mean (+/- SEM) serum concentration for these patients (3.8 +/- 0.8 ng/ml) was significantly higher than that of 52 disease-free patients coming to routine postoperative care (1.2 +/- 0.1 ng/ml) and of 74 healthy controls (1.1 +/- 0.07 ng/ml). Using a arbitrary limit of 2.2 ng/ml, pathologic serum levels of SCC were observed in 15 (38%) of 40 untreated patients, whereas only four (7.7%) of 52 tumor-free patients revealed an elevated serum SCC. Serial measurements of SCC were pretherapeutically available in 28 patients as well as during individual therapy and further follow-up. All but one of these patients had a normal serum SCC postoperatively. The authors' results demonstrate that the clinical value of SCC lies mainly in monitoring the course of the disease. Careful follow-up studies should be undertaken to determine whether serial determination of SCC is promising in early prediction of tumor reoccurrence.

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SCC-Antigen: ein sensitiver und spezifischer Tumormarker für Plattenepithelkarzinome?

Cited by 15 publications

References 0 publications

Bedeutung des SCC-Antigens in der Diagnostik und Verlaufskontrolle des Zervixkarzinoms: Eine kooperative Studie der Gynäkologischen Tumor-Marker-Gruppe (GTMG)

Bedeutung des SCC-Antigens in der Diagnostik und Verlaufskontrolle des Zervixkarzinoms: Eine kooperative Studie der Gynäkologischen Tumor-Marker-Gruppe (GTMG)

Tumormarker bei der Diagnostik und Verlaufsbeurteilung von Bronchialkarzinomen

Squamous cell carcinoma antigen in the diagnosis and treatment follow-up of oral and facial squamous cell carcinoma

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