Scarring alopecia and the dermatopathologist

Sperling, Leonard C.

doi:10.1034/j.1600-0560.2001.280701.x

Cited by 140 publications

(134 citation statements)

References 15 publications

Supporting

Mentioning

128

Contrasting

Unclassified

Order By: Relevance

“…This pathologic finding may be responsible for the permanent damage to the hair organ and support the theory that the bulge region is the site of hair regeneration [16].  Thickening of basement membrane and mucin deposition in the dermis is a feature of DLE [17].  Other laboratory abnormalities like antinuclear factor are frequently positive in DLE but not in LPP [14].…”

Section: Discussionmentioning

confidence: 76%

Lichen Planopilaris is a Common Scarring Alopecia among Iraqi Population

Sharquie¹,

Noaimi²,

Hameed³

2013

JCDSA

View full text Add to dashboard Cite

Background: Scarring alopecia like discoid lupus erythematosus, lichenplanopilaris and scarring folliculitis are common skin problems where differentiations between them are often difficult in many cases. Objective: To report, study and evaluate cases of lichen planopilaris and characterize the different clinical points in favor of this disease. Patients and Methods: This case series descriptive study was done at Department of Dermatology-Baghdad Teaching Hospital from January 2010 to November 2012. Sixty seven patients were included where histological and dermatological examinations were carried out to all patients regarding all relevant points related to the disease. Punch biopsies were performed from ten patients for histopathological study. Results: The mean age of onset of the disease was 36.7 ± 5 years with a mean duration of the disease being 4.4 ± 3 years. The male to female ratio was 1.4:1. The characteristic lesions were pigmented scarring moth eaten alopecia surrounded by pigmented hyperkeratotic follicular papules involving mainly the fronto-vertical and parietal scalp. Conclusions: Lichen planopilaris is a common cause of scalp scarring alopecia in adult and it has many characteristic clinical features which can facilitate differentiation from other pathologic scalp conditions like discoid lupus erythematosus.

show abstract

Section: Discussionmentioning

confidence: 76%

Lichen Planopilaris is a Common Scarring Alopecia among Iraqi Population

Sharquie¹,

Noaimi²,

Hameed³

2013

JCDSA

View full text Add to dashboard Cite

show abstract

“…Much of this data can only be obtained from transverse sections. In most of the cases, a good clinical/pathologic correlation is required, and so the clinicians are expected to provide demographic information as well as a brief description of the pattern of hair loss and a clinical differential diagnosis [6].…”

Section: Introductionmentioning

confidence: 99%

The Spectrum of Histopathological Lesions in Scarring Alopecia: A Prospective Study

Kumar

Yelikar²

2013

JCDR

View full text Add to dashboard Cite

Introduction: The aim of the article was to study the histo pathological features of various lesions of Scarring Alopecia (SA) and to classify Primary SA on the basis of the predominant type of inflammatory cell component. Scarring or cicatricial alopecias are those that are produced as a result of the malformation, damage or destruction of the pilosebaceous follicles, which are replaced by cicatricial tissue, in such a way that they cannot again produce hair. Material and Methods:This prospective study included 32 biopsy -proven cases of SA, who had attended our hospital. Primary SA was classified according to the North American Hair Research Society. The informed consents of the subjects and the institutional ethical clearance was obtained for the study. The SPSS, version 14 software was used to analyse the data.Frequencies and percentages were used to describe the data.Results: During the study period, 32 cases of scarring alopecia were diagnosed, of which 24 were primary SA and 8 were secondary SA. Among the primary SA, there were 23 cases of lymphocyte associated primary scarring alopecias, of which, 19 of lupus erythematosus, 3 of lichen planopilaris (LPP) and one case of non specific SA. 1 case of neutrophil associated primary scarring (folliculitis decalvans) was also noted and among the secondary SA, there were 4 cases of morphea and 1 case each of lupus vulgaris, congenital absence of skin, burn and sarcoidosis. Conclusion:To conclude, histopathology is a dependable tool for identifying the underlying cause in scarring alopecia, which is helpful for an early diagnosis and treatment.

show abstract

“…Histologic features of LP include a perifollicular lymphocytic infiltrate, with interface alterations involving the follicular epithelium [4,5,6]. These changes tend to be top-heavy.…”

Section: Introductionmentioning

confidence: 99%

“…Histologic features of LE include liquefaction degeneration of the basal cell layer and a perivascular and periadnexal lymphocytic infiltration on all levels of the dermis [6]. Civatte bodies may also be seen, although in smaller numbers than in LP [11, 12].…”

Section: Introductionmentioning

confidence: 99%

Value of Direct Immunofluorescence for Differential Diagnosis of Cicatricial Alopecia

Trachsler

Trüeb²

2005

Dermatology

View full text Add to dashboard Cite

Background: There are diverse causes of cicatricial alopecia characterized by lack of follicular ostia and irreversible loss of hair. While clinical differentiation between the causes may be difficult, particularly with regard to lichen planus (LP), lupus erythematosus (LE) and pseudopelade of Brocq (PB), it has been suggested that both histopathologic examination and direct immunofluorescence studies (DIF) are necessary for an accurate diagnosis. Objective: The aim of this study was to evaluate the diagnostic value of DIF studies in addition to histopathology in patients with cicatricial alopecia as a clinical feature. Methods: 136 scalp biopsy specimens received for histopathology and DIF during a 5-year period were reviewed. Results: Definitive diagnosis was achieved by careful evaluation of scalp biopsies. The most prevalent diagnoses in order of frequency were LP (26%), LE (21%) and folliculitis decalvans (20%). PB was diagnosed in 10%. In most cases, the diagnosis could be made on the basis of histopathology and independently of DIF. Characteristic DIF patterns showed high specificity, but low sensitivity for LP, and high specificity and sensitivity for LE. The DIF pattern in PB showed no difference to LP. Conclusions: Histopathology permits diagnosis in the majority of cicatricial alopecias. DIF is of value in histopathologically inconclusive cases, particularly when LE is in question.

show abstract

Scarring alopecia and the dermatopathologist

Cited by 140 publications

References 15 publications

Lichen Planopilaris is a Common Scarring Alopecia among Iraqi Population

Lichen Planopilaris is a Common Scarring Alopecia among Iraqi Population

The Spectrum of Histopathological Lesions in Scarring Alopecia: A Prospective Study

Value of Direct Immunofluorescence for Differential Diagnosis of Cicatricial Alopecia

Contact Info

Product

Resources

About