2005
DOI: 10.1159/000086436
|View full text |Cite
|
Sign up to set email alerts
|

Value of Direct Immunofluorescence for Differential Diagnosis of Cicatricial Alopecia

Abstract: Background: There are diverse causes of cicatricial alopecia characterized by lack of follicular ostia and irreversible loss of hair. While clinical differentiation between the causes may be difficult, particularly with regard to lichen planus (LP), lupus erythematosus (LE) and pseudopelade of Brocq (PB), it has been suggested that both histopathologic examination and direct immunofluorescence studies (DIF) are necessary for an accurate diagnosis. Objective: The aim of this study was to evaluate the diagnostic… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
50
2

Year Published

2013
2013
2022
2022

Publication Types

Select...
4
3
1

Relationship

1
7

Authors

Journals

citations
Cited by 56 publications
(53 citation statements)
references
References 65 publications
(64 reference statements)
1
50
2
Order By: Relevance
“…In the majority of the series, routine histology is usually sufficient for diagnosis, with only 6% of LPP and 7% of LE cases being diagnosed exclusively with DIF. The sensitivity of this technique for LPP is 34%, and the specificity is 95%; for LE, DIF sensitivity is reported as 83% and specificity, 93% (the percentage of positivity ranges between 63 and 100% according to the different reports) [23,24]. In our series, of 48 DIF studies performed, only 18 were positive and, from these, the diagnosis was made solely based on DIF results in only 10 cases due to the fact that histopathology was doubtful or nonspecific.…”
Section: Discussionmentioning
confidence: 99%
“…In the majority of the series, routine histology is usually sufficient for diagnosis, with only 6% of LPP and 7% of LE cases being diagnosed exclusively with DIF. The sensitivity of this technique for LPP is 34%, and the specificity is 95%; for LE, DIF sensitivity is reported as 83% and specificity, 93% (the percentage of positivity ranges between 63 and 100% according to the different reports) [23,24]. In our series, of 48 DIF studies performed, only 18 were positive and, from these, the diagnosis was made solely based on DIF results in only 10 cases due to the fact that histopathology was doubtful or nonspecific.…”
Section: Discussionmentioning
confidence: 99%
“…Increased dermal mucin is usually present both superficially and deep and is best detected in alcian blue-stained sections. Direct immunofluorescence studies demonstrate dense granular deposition of immunoglobulin (most commonly IgG, but IgM and IgA may also be present) and complement factor C3 at the dermal-epidermal junction in 76% of cases [17]. As with the other primary scarring alopecias, specifically LPP, there is no ideal treatment for the alopecias related to LE.…”
Section: Discussionmentioning
confidence: 99%
“…Based on previous studies [3], globular deposits (colloid bodies) of immunoglobulins or C3 on the papillary dermis or around the hair follicles were considered characteristic of LPP. All other findings were considered nonspecific, and the absence of staining was considered a negative finding.…”
Section: Methodsmentioning
confidence: 99%
“…It has been shown to be useful for differential diagnosis of cicatricial alopecias [3]. DIF patterns in LPP consist of numerous globular deposits of immunoglobulins, particularly IgM (colloid bodies), and deposits of C3 in the papillary dermis.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation