Scanning electron microscopic observations of early plaque formation in vivo on enamel specimens treated with delmopinol

Collaert, Bruno; Attström, Rolf; Holmstrup, Palle; Fredebo, L.; Hase, Jan C.

doi:10.1111/j.1600-051x.1993.tb00367.x

Cited by 11 publications

(8 citation statements)

References 15 publications

(11 reference statements)

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“…The inhibitory effect of delmopinol on plaque formation was more pronounced compared to placebo, which is in agreement with previous studies (8)(9)(10)(11)(12)(13). Comparing baselines values after professional toothcleaning of the two test periods revealed a slightly higher Plaque Index score in the second than the first test period (P=0.016).…”

Section: Discussionsupporting

confidence: 91%

Development of plaque and gingivitis after mouthrinsing with 0.2% delmopinol hydrochloride

Hase¹,

Söder

et al. 1995

European J Oral Sciences

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A double-blind, randomized, 2-wk experimental gingivitis clinical trial with cross-over design in 14 dental students was conducted in order to study the efficacy and safety of delmopinol hydrochloride solution (2 mg/ml), used with no other oral hygiene procedures, in comparison with placebo. Plaque formation was measured by the Quigley & Hein Plaque Index and gingivitis was assessed by bleeding on probing according to Mühlemann & Son. Rinsing with delmopinol resulted in lower plaque scores compared to placebo. The development of gingivitis was weak during the 2-wk test periods, and thus no conclusive results were obtained. As in previous studies, the most frequent adverse event when rinsing with delmopinol was a transient anaesthetic sensation in the oral mucosa. The results showed that rinsing with delmopinol hydrochloride solution (2 mg/ml) for 60 s twice daily with no other oral hygiene procedures led to less plaque formation than rinsing with placebo. This study also showed good tolerance and acceptability of mouthrinsing with delmopinol.

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Section: Discussionsupporting

confidence: 91%

Development of plaque and gingivitis after mouthrinsing with 0.2% delmopinol hydrochloride

Hase¹,

Söder

et al. 1995

European J Oral Sciences

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“…(32.5%). These re- suits are in agreement with the presence of coccoid-dominated plaque in subjects applying deltnopinol, as observed by light atid scanning electron tnicroscopy (6,8). On day 7 an Increase in the proportion of Streptoeoecus spp., Haemophilus spp.…”

Section: Discussionsupporting

confidence: 85%

“…Although the agents did not eliminate plaque, they selectively altered the subgingival fiora with higher percentages of gram-positive cocci and lower percentages of gram-negative rods and Forphyromonas gingivalis compared to the control atiitnals. The amino alcohol, delmopitiol hydrochloride (Decapinol'") has the potential to change the composition of the supragingival plaque (5,6,8). Microscopic evaluation of the supragingival plaque adjacent to the gingival margin showed that it was dotninated by coccoid microbial forms when delmopinol was applied or rinsed with for 14 days.…”

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confidence: 99%

Microbiology of early supragingival plaque development after delmopinol treatment

Collaert

Edwardsson

Attström

et al. 1993

Oral Microbiology and Immunology

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The aim of this double blind, cross-over, microbiological study was to compare the effect of topical application of the plaque control agent 0.5% delmopinol HCl with placebo on early supragingival plaque formation. Six subjects underwent 7 periods (0.5, 1, 2, 8 and 24 h and 3 and 7 days) of placebo and delmopinol application, respectively. At the start of each study period the teeth were professionally cleaned and 2 ml of placebo and delmopinol 0.5%, respectively, were applied on all teeth (twice daily for periods lasting 24 h or more). At the end of each period, supragingival plaque samples of one upper and one lower buccal tooth surface were collected separately and cultured on anaerobically incubated Brucella blood agar, on aerobically incubated blood agar and on selective media for the enumeration of Streptococcus spp., Haemophilus spp., Actinomyces spp., Veillonella spp., Neisseria spp. and Fusobacterium spp. The total anaerobic cultivable microflora after delmopinol use was 10-100 times lower than after placebo use. Compared with placebo, the proportion of cultivable aerobes (61.3%), Streptococcus spp. (104.8%) and Haemophilus spp. (82.3%) increased and the proportion of Actinomyces spp. (86.1%), Veillonella spp. (60.5%), Neisseria spp. (96.9%) and Fusobacterium spp. (60.6%) decreased after 7 days. Short-term application of 0.5% delmopinol HCl on supragingival dental plaque regrowth resulted in a reduction of the number of cultivable microorganisms in the plaque and produced a shift in the cultivable plaque composition.

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“…No serious adverse events were reported in this study. As in previous studies (Collaert et al 1992a, b, 1993a, b, 1994, Moran et al, 1992, Rundegren et al, 1992a, Hase et al 1995a, b, Claydon et al 1996, Klinge et al 1996, a transient anaesthetic sensation, especially located at the tip of the tongue, was the dominant adverse event reported in the delmopinol group. At the 6-month examination, however, this side-effect was reported with the same frequency also in the chlorhexidine group.…”

Section: Discussionsupporting

confidence: 72%

“…The results of the microbiological examinations in this study and previous clinical studies indicate that painting (Collaert et al, 1992b(Collaert et al, , 1993a and rinsing (Collaert et al 1992a) with delmopinol delays and interferes with dental plaque maturation. In this study, the 0.2% chlorhexidine rinsing solution showed 38% lower plaque scores than placebo.…”

Section: Discussionsupporting

confidence: 70%

6‐month use of 0.2% delmopinol hydrochloride in comparison with 0.2% chlorhexidine digluconate and placebo

Hase¹,

Attström

Edwardsson

et al. 1998

J Clinic Periodontology

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A double-blind, randomised, 6-month clinical trial with parallel group design in 149 patients with gingivitis was conducted to study the efficacy and safety of delmopinol hydrochloride 2 mg/ml (0.2% w/v, Decapinol Mouthwash) used for partly supervised mouthrinsing in comparison with chlorhexidine digluconate 2 mg/ml (0.2% w/v, Hibitane Dental, ICI Pharmaceuticals, UK) and placebo as an addition to normal oral hygiene. Assessments of efficacy were performed using the plaque index and bleeding on probing (BOP). Delmopinol showed 22% lower plaque index scores than placebo after 3 months (p<0.01) and 13% lower scores after 6 months. The corresponding figures for chlorhexidine were 38% (p<0.001) and 38% (p<0.001) after 3 and 6 months, respectively. Bleeding on probing was reduced for delmopinol in comparison with placebo by 11% after 3 months and by 18% (p<0.05) after 6 months. For chlorhexidine the corresponding figures were 18% (p<0.01) and 22% (p<0.01) after 3 and 6 months, respectively. While chlorhexidine showed greater plaque reduction than delmopinol (p<0.01 at 6 months), no statistically significant difference was reached between these two solutions regarding BOP. Both active solutions showed an increased amount of dental calculus in comparison with placebo. A transient anaesthetic sensation in the oral mucosa and taste affection were commonly reported adverse events in both the delmopinol and the chlorhexidine groups. The number of patients withdrawn from treatment due to adverse events or lack of cooperation was 7 in the chlorhexidine group, 4 in the placebo group and 1 in the delmopinol group. The results showed that rinsing with either 0.2% delmopinol hydrochloride or 0.2% chlorhexidine digluconate twice daily for 60 secs for 6 months results in less plaque formation and gingivitis than rinsing with placebo. Mouthrinsing with the 0.2% delmopinol hydrochloride solution was well accepted in this study.

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Scanning electron microscopic observations of early plaque formation in vivo on enamel specimens treated with delmopinol

Cited by 11 publications

References 15 publications

Development of plaque and gingivitis after mouthrinsing with 0.2% delmopinol hydrochloride

Development of plaque and gingivitis after mouthrinsing with 0.2% delmopinol hydrochloride

Microbiology of early supragingival plaque development after delmopinol treatment

6‐month use of 0.2% delmopinol hydrochloride in comparison with 0.2% chlorhexidine digluconate and placebo

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