Scaffolds for bone tissue engineering

Martin-Piedra, Alberto; Martín-Piedra, Laura

doi:10.15568/am.2019.806.re01

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bones are the second-most transplanted tissue in the world, with more than four million surgeries per year performed using bone grafts or substitutes [ 1 ]. Conventional regeneration techniques involve the transplantation of a living bone tissue either from one part of the body to another in the same patient (autograft), from one individual (living or dead) to another (allotransplant or allograft), or even from animals (xenograft); the latter presents low use expectations owing to its scarce utility for medical needs and other complications [ 2 ]. Nowadays, tissue transplants from the same patient are the most widely used and recommended technique because they offer all the necessary properties for a bone-graft material.…”

Section: Introductionmentioning

confidence: 99%

“…To mitigate the largest number of problems, bioengineering and materials science have been used to advance toward tissue engineering or regenerative medicine, whose aim is to develop biological substitutes to restore and/or improve natural tissue functions by cell and tissue stimulation and manipulation. In this sense, considerable progress has been reported in this field in the last 20 years [ 2 ]. Tissue engineering combines three-dimensional (3D) lattices (scaffolds) of cells with biologically active molecules and growth factors that promote cell evolution to create functional bone tissues [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Propolis Impregnation on Polylactic Acid (PLA) Scaffolds Loaded with Wollastonite Particles against Staphylococcus aureus, Staphylococcus epidermidis, and Their Coculture for Potential Medical Devices

Moreno,

Orozco,

Ocampo

et al. 2023

Polymers

View full text Add to dashboard Cite

Several diseases and injuries cause irreversible damage to bone tissues, which may require partial or total regeneration or replacement. Tissue engineering suggests developing substitutes that may contribute to the repair or regeneration process by using three-dimensional lattices (scaffolds) to create functional bone tissues. Herein, scaffolds comprising polylactic acid and wollastonite particles enriched with propolis extracts from the Arauca region of Colombia were developed as gyroid triply periodic minimal surfaces using fused deposition modeling. The propolis extracts exhibited antibacterial activity against Staphylococcus aureus (ATCC 25175) and Staphylococcus epidermidis (ATCC 12228), which cause osteomyelitis. The scaffolds were characterized using scanning electron microscopy, Fourier-transform infrared spectroscopy, differential scanning calorimetry, contact angle, swelling, and degradation. Their mechanical properties were assessed using static and dynamic tests. Cell viability/proliferation assay was conducted using hDP-MSC cultures, while their bactericidal properties against monospecies cultures (S. aureus and S. epidermidis) and cocultures were evaluated. The wollastonite particles did not affect the physical, mechanical, or thermal properties of the scaffolds. The contact angle results showed that there were no substantial differences in the hydrophobicity between scaffolds with and without particles. Scaffolds containing wollastonite particles suffered less degradation than those produced using PLA alone. A representative result of the cyclic tests at Fmax = 450 N showed that the maximum strain reached after 8000 cycles is well below the yield strain (i.e., <7.5%), thereby indicating that even under these stringent conditions, these scaffolds will be able to work properly. The scaffolds impregnated with propolis showed a lower % of cell viability using hDP-MSCs on the 3rd day, but these values increased on the 7th day. These scaffolds exhibited antibacterial activity against the monospecies cultures of S. aureus and S. epidermidis and their cocultures. The samples without propolis loads did not show inhibition halos, whereas those loaded with EEP exhibited halos of 17.42 ± 0.2 mm against S. aureus and 12.9 ± 0.5 mm against S. epidermidis. These results made the scaffolds possible bone substitutes that exert control over species with a proliferative capacity for the biofilm-formation processes required for typical severe infectious processes.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Propolis Impregnation on Polylactic Acid (PLA) Scaffolds Loaded with Wollastonite Particles against Staphylococcus aureus, Staphylococcus epidermidis, and Their Coculture for Potential Medical Devices

Moreno,

Orozco,

Ocampo

et al. 2023

Polymers

View full text Add to dashboard Cite

show abstract

Hidrogeles de colágeno acoplados con hidroxiapatita para aplicaciones en ingeniería tisular

et al. 2020

View full text Add to dashboard Cite

Los hidrogeles basados en colágeno son redes tridimensionales (3D) con la capacidad de absorber agua y una alta biocompatibilidad para utilizarlos en la reparación de tejidos dañados. Estos materiales presentan pobres propiedades mecánicas y velocidades de degradación rápidas, limitando su aplicación a estrategias de ingeniería tisular y biomedicina; por ésto, la incorporación de fases inorgánicas en la matriz 3D del colágeno como la hidroxiapatita ha contribuido en la mejora de sus propiedades, incrementado la eficiencia de los hidrogeles híbridos obtenidos. Este trabajo, presenta las contribuciones más relevantes relacionadas con los sistemas de hidrogeles basados en colágeno y partículas de hidroxiapatita dispersas dentro de la matriz colagénica, lo que evidencia que la combinación de los materiales no altera la biocompatibilidad y biodegradabilidad típicas del colágeno, permitiendo la adhesión, proliferación, crecimiento celular y control del metabolismo de las células implicadas en los procesos de una reparación ósea, presentando a los hidrogeles como una estrategia para su uso potencial en la ingeniería tisular.

show abstract

Scaffolds for bone tissue engineering

Cited by 2 publications

References 0 publications

Effects of Propolis Impregnation on Polylactic Acid (PLA) Scaffolds Loaded with Wollastonite Particles against Staphylococcus aureus, Staphylococcus epidermidis, and Their Coculture for Potential Medical Devices

Effects of Propolis Impregnation on Polylactic Acid (PLA) Scaffolds Loaded with Wollastonite Particles against Staphylococcus aureus, Staphylococcus epidermidis, and Their Coculture for Potential Medical Devices

Hidrogeles de colágeno acoplados con hidroxiapatita para aplicaciones en ingeniería tisular

Contact Info

Product

Resources

About