SB-202742, a Novel β-Lactamase Inhibitor Isolated from Spondias mombin

Coates, Nigel; Gilpin, Martin L.; Gwynn, Mick N.; Lewis, David E.; Milner, Peter H.; Spear, S. R.; Tyler, John W.

doi:10.1021/np50107a016

Cited by 59 publications

(34 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Preliminary reports suggest that the phenolic acid, 6-alkenyl-salicylic acid from Spondias mombin are responsible for the antibacterial and molluscicidal of this plant extract (Corthout et al, 1994). In another study, the anacardis acid derivative from the hexane extract of the plant was showed to possess beta lactamase inhibitory properties (Coates et al, 1994). Keshinro, 198524 Wound-healing Deferreyra, 1981, 1997Jaramillo and Ahnmadebormol, 1983;Ajao et al, 1985;Villegas et al, 1997 The plant extract has been shown to possess phenolic derivatives with antiherpes and antioxidant properties, which have been formulated for use in Brazil (Corthout et al, 1992;Caster et al, 1998;Shultes and Raffauf, 1990;Mats, 1994).…”

Section: Biological Activitiesmentioning

confidence: 93%

“…There is evidence of arabinofuranose residues as structural features of the Spondias gums. Coates et al (1994) isolated a novel betalactamase inhibitor from Spondias mombin. Two caffeoyl esters: 2-0-caffeoyl-(+)-allohyroycritic acid and chlorogenic and butyl ester with antiviral properties were isolated by Corthout et al (1992).…”

Section: Phytochemistry Of Spondias Mombinmentioning

confidence: 99%

“…The presence of these active compounds has been reported for several activities like antibacterial (Corthout et al, 1994;Ajao et al, 1985), anti-inflammation (Abad et al, 1996), haemostatic activity (Kone-Bamba et al, 1987), anti-microbial (Corthout et al, 1994;Abo et al, 1999;Verpoorte and Dihal, 1987), antioxidant (Castner et al, 1998;Shaltes and Raffauf, 1990), abortifacients (Akubue et al, 1983;Offiah and Anyanwu, 1989), purgatives (Akubue et al, 1983), hypnotics (Akubue et al, 1983;Ayoka et al, 2005), anti-diarrhoea (Akubue et al, 1983), anti-helmintic (Ademola et al, 2005), anti-malarial (Carabalo et al, 2004), wound-healing (Villegas et al, 1997;Ajao et al, 1985), enzyme inhibitor (Coates et al, 1994), increased capillary permeability in rats (Villegas et al, 1997), anti-free radical action, anti-aging, reduced glutathione synthesis (Pauly and Fleury, 2002). The phenolic acids composition was observed to cause antibacterial and molluscicidal effect (Corthout et al, 1994).…”

Section: Phytochemistry Of Spondias Mombinmentioning

confidence: 99%

See 2 more Smart Citations

Medicinal and economic value of spondias mombin

Ayoka¹,

Akomolafe²,

.³

et al. 2010

African Journal of Biomedical Research

View full text Add to dashboard Cite

This article reviewed the folk medical value of Spondias mombin with the correlated research findings on the uses of Spondias mombin. Most of the folk uses had been scientifically proven in most of the regions where those beliefs are based. The plant was described with habitat, the local uses including the uses of its parts mentioned. We reviewed the ethnomedicinal uses, the biological activities and the phytochemistry of Spondias mombin.

show abstract

Section: Biological Activitiesmentioning

confidence: 93%

Section: Phytochemistry Of Spondias Mombinmentioning

confidence: 99%

Section: Phytochemistry Of Spondias Mombinmentioning

confidence: 99%

See 1 more Smart Citation

Medicinal and economic value of spondias mombin

Ayoka¹,

Akomolafe²,

.³

et al. 2010

African Journal of Biomedical Research

View full text Add to dashboard Cite

show abstract

“…Preliminary reports suggest that the phenolic acid, 6-alkenylsalicylic acid in the leaf extract of Spondias mombin are responsible for its antibacterial property 6 . In another study, the anacardis acid derivative from the hexane extract of the plant was showed to possess beta lactamase inhibitory properties 7 . The anti-malarial activity of Spondias mombin discovered lately is said to have been linked to a range of compounds like anthraquinones, berberine, flavonoids, naphthoquinones, sesquiterpenes, quassiniods, indole and quinoline alkaloids present in the leaves 8 .…”

Section: Introductionmentioning

confidence: 98%

In Vitro Evaluation of Antioxidant Activity of Spondias Mombin Leaf Extract: Discovering Future Avenues for an Affordable and Efficient Antioxidant

Bhandarkar¹,

Bhat²,

Vinodraj³

et al. 2015

Int. Res. J. Pharm.

View full text Add to dashboard Cite

Spondias mombin is valued ethno medically in folkloric medicine. This medicinal plant according to traditional claim is said to cure various infectious and inflammatory ailments of gastrointestinal and genitourinary tract. Formation of reactive oxygen species (ROS) in inflammatory conditions is said to result in oxidative stress. The antibacterial and anti-inflammatory properties of Spondias mombin especially its leaves, have been linked to a range of compounds in it viz., anthraquinones, berberine, flavonoids, naphthoquinones, sesquiterpenes, quassiniods, indole and quinoline alkaloids. Hence, we aimed at exploring the antioxidant potential of the leaf extract of Spondias mombin by in vitro methods. The ethanolic extract of leaves was subjected to spectrophotometric analysis and DPPH methods to explore its reducing potential. The total phenolic and total flavonoid content was estimated by colorimetric methods. It was observed that ethanolic extract of Spondias mombin demonstrated a dose-dependent increase in the reducing property, with higher potency than the reference compound sodium metabisulphate. Spondias mombin shade dried leaf powder macerated and later extracted with hot water possessed a significantly high content of flavonoids than those extracted with other solvents. The leaf extract of Spondias mombin possesses significant antioxidant activity that may be attributed to its high flavonoid content which could afford protection in inflammatory conditions. This finding strengthens its widespread use in traditional medicine. Animal studies and clinical trials are necessary to validate these beneficial properties and translate them into clinical utility.

show abstract

“…Crude Spondias mombin (L. Anacardiaceae) leaves extracts have been reported to modulate multiple behaviours (novelty-induced, sedative, antipsychotic, antiepileptic) in mice and rats (Ayoka et al 2005). Previous studies have reported extraction of different chemical compounds (phenolic acid 6-alkenyl-salicylic acid, anarcardic acid and phenolic derivatives) from Spondias mombin, which exhibited different biological properties including antibacterial, molluscicidal, antiviral and antioxidant effects (Corthout et al, 1994;Coates et al, 1994;Castner et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Effect of fractionated extracts and isolated pure compounds of spondias mombin (<i>L. Anacardiaceae</i>) leaves on novelty-induced rearing and grooming behaviors in mice.

Ayoka¹,

Owolabi²,

Bamitale³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

This study attempted to elucidate the neurotransmitter systems involved in the neurophysiological properties of ethanolic extract, fractions and pure isolates of Spondias mombin leaves in mice (n = 6) after intraperitoneal (i.p.) route of administration.The crude ethanolic extract of spondian mombin leaves was fractionated using the partitioning method to obtain the ethylacetate, butanolic and aqueous fractions. Open column chromatographic fractionation of the ethylacetate fraction yielded seven sub-fractions, out of which the pure coumaroyl, quercetine and gallic acid derivatives were obtained after purification on Sephadex LH 20. The ethanolic extract, butanolic fractions, ethylacetate subfractions and pure isolates of the spondian mombin leaves were tested on novelty-induced rearing and grooming behaviours in mice with standard pharmacological tools using the open field method.The extract and its fractions decreased novelty-induced rearing in a dose-dependent manner. While the Coumaroyl derivative had no effect on novelty-induced rearing, it significantly reversed the inhibitory effect of yohimbine, propranolol and haloperidol on novelty-induced rearing. Quercetin significantly potentiated the inhibitory effect of yohimbine on noveltyinduced rearing. Naloxone significantly potentiated the quercetine-induced suppression of novelty-induced rearing. Gallic acid derivative significantly potentiated the inhibitory effect of yohimbine on novelty-induced rearing. Naloxone, atropine and haloperidol pretreatments significantly potentiated gallic acid derivative-induced suppression of novelty-induced rearing .The extract and its fractions had biphasic effect on novelty-induced grooming in mice. Coumaroyl derivative significantly increased novelty-induced grooming, while quercetine and gallic acid derivative decreased novelty-induced grooming significantly. The three pure isolates significantly reversed the effects of yohimbine and atropine on the noveltyinduced grooming in mice. Propranolol-induced increase in novelty-induced grooming was significantly reversed by coumaroyl and gallic acid derivatives. Pre-treatment with naloxone significantly increased the gallic acid derivative-induced suppression of novelty-induced grooming. Pre-treatment with haloperidol reversed the effect of coumaroyl derivative and potentiated the inhibitory effect of quercetine derivative and gallic acid derivative significantly.This study suggested that adrenergic and dopaminergic neuro-transmissions are strongly involved in the neural mechanisms of the effect of the three pure isolates derivative, while opioid neuro-transmission is strongly linked with the neural mechanism of behavioural effect of coumaroyl derivative.

show abstract

SB-202742, a Novel β-Lactamase Inhibitor Isolated from Spondias mombin

Abstract: SB-202742 [1], an anacardic acid derivative possessing beta-lactamase inhibitory activity, has been isolated from a hexane extract of the plant, Spondias mombin. Its isolation, structure determination, and biological activity are reported herein.

Cited by 59 publications

References 10 publications

Medicinal and economic value of spondias mombin

Medicinal and economic value of spondias mombin

In Vitro Evaluation of Antioxidant Activity of Spondias Mombin Leaf Extract: Discovering Future Avenues for an Affordable and Efficient Antioxidant

Effect of fractionated extracts and isolated pure compounds of spondias mombin (<i>L. Anacardiaceae</i>) leaves on novelty-induced rearing and grooming behaviors in mice.

Contact Info

Product

Resources

About