SARS-CoV-2 B.1.1.7 Decline Is Not Driven by the Introduction of a More Successful Variant

Rodríguez‐Grande, Cristina; Buenestado‐Serrano, Sergio; Alcalá, Luís; Sola‐Campoy, Pedro J.; Molero-Salinas, Andrea; Otero-Sobrino, Álvaro; Rodríguez-Grande, Jorge; García, Víctor Manuel de la Cueva; Adán‐Jiménez, Javier; Rico-Luna, Carla; Losada, Carmen; Catalán, Pilar; Muñóz, Patricia; Pérez‐Lago, Laura; Viedma, Darío García de

doi:10.1128/spectrum.01128-21

Cited by 4 publications

(3 citation statements)

References 10 publications

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Section: Methodsmentioning

confidence: 99%

“…Data were stratified in 3 periods according to the circulation of the different SARS-CoV-2 variants: Wuhan and Alpha: March 1, 2020 to June 30, 2021; Delta: July 1 to November 30, 2021 and Omicron: December 1, 2021 to January 15, 2023. 5,6 Statistical analyses were performed with R statistical software (v3.5.3). Frequency distributions and rates were used to summarize descriptive analyses.…”

Section: Methodsmentioning

confidence: 99%

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Clinical Relevance of RSV and SARS-CoV-2 Coinfections in Infants and Young Children

Rodriguez-Fernandez,

González-Martínez,

Perez-Moreno

et al. 2023

Pediatric Infectious Disease Journal

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We analyzed the frequency, clinical impact and severity of respiratory syncytial virus (RSV) and SARS-CoV-2 coinfections in a single pediatric center between March 2020 and January 2023. Compared to single RSV infections, RSV/SARS-CoV-2 coinfections were uncommon (2.1%), occurred more frequently during circulation of omicron, and were associated with increased disease severity as defined by longer hospitalization and increased need for high-flow nasal cannula.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Clinical Relevance of RSV and SARS-CoV-2 Coinfections in Infants and Young Children

Rodriguez-Fernandez,

González-Martínez,

Perez-Moreno

et al. 2023

Pediatric Infectious Disease Journal

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“…T3 (Omicron period): patients hospitalized for RSV bronchiolitis from December 1, 2021, to December 31, 2021, during the circulation of the Omicron SARS-CoV-2 variant. 12…”

Section: Methodsmentioning

confidence: 99%

Clinical Phenotype of Respiratory Syncytial Virus Bronchiolitis before and during the Coronavirus Disease 2019 Pandemic

et al. 2022

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Objective The main objective of this report was to comprehensively analyze the clinical characteristics of children hospitalized with respiratory syncytial virus (RSV) infections in 2021 during the coronavirus disease 2019 (COVID-19) pandemic and to compare them with those in the five previous RSV seasons. We hypothesized that the clinical and demographic features of children hospitalized with RSV infection in 2021 were different from those hospitalized in previous respiratory seasons. Study Design In this retrospective observational study, children younger than 2 years hospitalized with RSV bronchiolitis from January 1, 2015, to December 31, 2021, at the Department of Pediatrics of the Hospital Gregorio Marañón, Madrid, Spain, were included. We compared the clinical characteristics of children hospitalized with RSV bronchiolitis in the five seasons before the COVID-19 pandemic and during the subsequent off-seasonal surge of RSV infections. Results We found a significant reduction in hospitalizations for RSV bronchiolitis during the usual winter epidemic period due to the COVID-19 pandemic. Children hospitalized with RSV infection in 2021, during the COVID-19 pandemic, were older than children hospitalized in the prepandemic period (2015–2020; 4.0 [1.6–9.2] vs. 3 [1.5–6.5] months; p < 0.01). We also found shorter duration of oxygen days during the COVID-19 period compared with previous respiratory seasons (3 [2–5] vs. 4 [2–6] days; p = 0.02). Conclusion The COVID-19 pandemic modified the RSV seasonality with a significant reduction in RSV hospitalizations during the expected 2020–2021 season and a reappearance of RSV 7 months later than expected. We also found changes in the median age of children with RSV bronchiolitis during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic compared with the prepandemic RSV seasons and shorter duration of oxygen days suggesting a modest reduction in disease severity. We hypothesize that this observation reflects the lack of RSV circulation in the previous months (April 2020-March 2021), with a larger pool of vulnerable infants that had not been previously infected. Key Points

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Genomic surveillance of SARS-CoV-2 in Puerto Rico enabled early detection and tracking of variants

et al. 2022

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Background Puerto Rico has experienced the full impact of the COVID-19 pandemic. Since SARS-CoV-2, the virus that causes COVID-19, was first detected on the island in March of 2020, it spread rapidly though the island’s population and became a critical threat to public health. Methods We conducted a genomic surveillance study through a partnership with health agencies and academic institutions to understand the emergence and molecular epidemiology of the virus on the island. We sampled COVID-19 cases monthly over 19 months and sequenced a total of 753 SARS-CoV-2 genomes between March 2020 and September 2021 to reconstruct the local epidemic in a regional context using phylogenetic inference. Results Our analyses reveal that multiple importation events propelled the emergence and spread of the virus throughout the study period, including the introduction and spread of most SARS-CoV-2 variants detected world-wide. Lineage turnover cycles through various phases of the local epidemic were observed, where the predominant lineage was replaced by the next competing lineage or variant after ~4 months of circulation locally. We also identified the emergence of lineage B.1.588, an autochthonous lineage that predominated in Puerto Rico from September to December 2020 and subsequently spread to the United States. Conclusions The results of this collaborative approach highlight the importance of timely collection and analysis of SARS-CoV-2 genomic surveillance data to inform public health responses.

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SARS-CoV-2 B.1.1.7 Decline Is Not Driven by the Introduction of a More Successful Variant

Cited by 4 publications

References 10 publications

Clinical Relevance of RSV and SARS-CoV-2 Coinfections in Infants and Young Children

Clinical Relevance of RSV and SARS-CoV-2 Coinfections in Infants and Young Children

Clinical Phenotype of Respiratory Syncytial Virus Bronchiolitis before and during the Coronavirus Disease 2019 Pandemic

Genomic surveillance of SARS-CoV-2 in Puerto Rico enabled early detection and tracking of variants

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