Sarisan from leaves ofPiper affinis hispidinervum C. DC (long pepper)

Bizzo, H. R.; Lopes, Daniel Simões; Abdala, Rodrigo V.; Pimentel, F. A.; Souza, João Artur de; Pereira, Maria Julia Salim; Bergter, Lothar; Guimarães, Elsie Franklin

doi:10.1002/ffj.957

Cited by 28 publications

(20 citation statements)

References 10 publications

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“…Piper aduncum and P. marginatum presented compounds already reported as insecticides in previous works, such as dillapiol, asaricine (sarisan), piperitone and myristicin (Bizzo et al, 2001;Morais et al, 2007;Qin, Huang, Li, Chen, & Peng, 2010;Souto et al, 2012;Santana et al, 2015;Ribeiro, Camara, & Ramos, 2016;Krinski & Foerster, 2016). For P. caldense, P. fuligineum, P. Mollicomum, and P. mosenii, there are no studies regarding the insecticidal activity, and our work is the first to test the ovicidal activity against a lepidopteran pest of importance in Brazilian agriculture.…”

Section: Discussionmentioning

confidence: 98%

Ovicidal effect of the essential oils from 18 Brazilian Piper species: controlling Anticarsia gemmatalis (Lepidoptera, Erebidae) at the initial stage of development

2018

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ABSTRACT. The toxicities of essential oils (EOs) from 18 species of Brazilian Piperaceae were assessed on eggs of the velvetbean caterpillar, Anticarsia gemmatalis. Oils were extracted using steam distillation, and dilutions were made for bioassays at concentrations of 0.25, 0.5, 1.0, 2.0, and 4.0%. All EOs reduced larval hatching. The lowest lethal concentrations were obtained from Piper fuligineum (SP), Piper mollicomum "chemotype 1" (SP), Piper mosenii (PR), Piper aduncum (PA) and Piper marginatum (PA). Ovicidal activity is related to the potential toxicity of several compounds, especially dilapiolle, myristicin, asaricine, spathulenol and piperitone. According to our results, EOs from 16 Brazilian Piper species have potential for use as biorational botanical insecticides.

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Section: Discussionmentioning

confidence: 98%

Ovicidal effect of the essential oils from 18 Brazilian Piper species: controlling Anticarsia gemmatalis (Lepidoptera, Erebidae) at the initial stage of development

2018

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“…For example, myristicin, present at 3.6% in the tested EO, sarisan (BIZZO et al, 2001) or safrole (HUANG et al, 1999), all of which have a methylenedioxyphenyl group in their structure are natural insecticides that could be the target of such association. Brazão et al (2014), when assessing the EO extracted from P. aduncum against susceptible and resistant isolates of Staphylococcus spp., also showed the combined bactericidal action of dillapiole and myristicin (1 to 2%), lending further support to our conclusions.…”

Section: Discussionmentioning

confidence: 99%

Piper aduncum against Haemonchus contortus isolates: cross resistance and the research of natural bioactive compounds

Gaínza

Fantatto

Chaves

et al. 2016

Rev. Bras. Parasitol. Vet.

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The anthelminthic activity of the essential oil (EO) of Piper aduncum L. was tested in vitro on eggs and larvae of resistant (Embrapa2010) and susceptible (McMaster) isolates of Haemonchus contortus. The EO was obtained by steam distillation and its components identified by chromatography. EO concentrations of 12.5 to 0.02 mg/mL were used in the egg hatch test (EHT) and concentrations of 3.12 to 0.01 mg/mL in the larval development test (LDT). Inhibition concentrations (IC) were determined by the SAS Probit procedure, and significant differences assessed by ANOVA followed by Tukey's test. In the EHT, the IC 50 for the susceptible isolate was 5.72 mg/mL. In the LDT, the IC 50 and IC 90 were, respectively, 0.10 mg/mL and 0.34 mg/mL for the susceptible isolate, and 0.22 mg/mL and 0.51 mg/mL for the resistant isolate. The EO (dillapiole 76.2%) was highly efficacious on phase L 1 . Due to the higher ICs obtained for the resistant isolate, it was raised the hypothesis that dillapiole may have a mechanism of action that resembles those of other anthelmintic compounds. We further review and discuss studies, especially those conducted in Brazil, that quantified the major constituents of P. aduncum-derived EO.Keywords: Isolates, Haemonchus contortus, cross resistance, dillapiole, synergy. ResumoEste estudo avaliou a atividade anti-helmíntica in vitro do óleo essencial (OE) de Piper aduncum L. sobre ovos e larvas de Haemonchus contortus, verificando se um isolado resistente (Embrapa2010), apresentaria o mesmo comportamento que um sensível (McMaster). O OE foi obtido por arraste a vapor e analisado por cromatografia para identificação dos constituintes. O óleo foi avaliado nas concentrações de 12,5 a 0,02 mg/mL no Teste de eclosão dos ovos (TEO) e nas concentrações de 3,12 a 0,01 mg/mL no Teste de desenvolvimento larvar (TDL). As concentrações inibitórias (CI) foram determinadas pelo procedimento Probit do SAS e as diferenças estatísticas geradas pela ANOVA seguida pelo teste de Tukey. Para o isolado sensível obteve-se CI 50 de 5,72 mg/mL no TEO. No TDL o óleo apresentou CI 50 e CI 90 de 0,10 mg/mL e 0,34 mg/mL para o isolado sensível e 0,22 mg/mL e 0,51 mg/mL para o resistente, respectivamente. Demonstrou-se que o OE (dilapiol 76,2%) teve alta eficácia sobre a fase L 1 . Devido às elevadas CIs obtidas para o isolado resistente, levantou-se a hipótese de que o dilapiol talvez possua um mecanismo de ação semelhante a algum grupo anti-helmíntico. O artigo faz uma revisão e discute estudos de quantificação dos constituintes majoritários do OE de P. aduncum, destacando os realizados no Brasil.

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“…For identification, the unknown compound was isolated by CC on silica gel and eluted with hexane-ethyl acetate mixtures. After 1 H and 13 CNMR studies, it was identified as sarisan (Bizzo et al, 2001). …”

Section: Monoterpenes and Sesquiterpenes (Plant Volatiles)mentioning

confidence: 99%