Sarcoma of the Ewing Family in Pregnancy: A Case Report of Intrauterine Fetal Death after Induction of Chemotherapy

Abstract

Ewing’s sarcoma is an ultra-orphan disease (2/1,000,000/year) which requires a multimodal therapy approach in high-volume centers. Treatment consists of pre-operative therapy followed by surgery and post-operative combination of chemo-radiotherapy. Experience with diagnosis and therapy of Ewing’s sarcoma in pregnancy is very limited. We herein report the case of an atypical Ewing’s sarcoma detected in the second trimester of gestation. Neoadjuvant chemotherapy was initiated and resulted in substantial tumor shrinkage and intrauterine fetal death. The rare nature of this condition underlines once more the need for a multidisciplinary team to improve the quality of care for this highly special patient collective.

Bone and soft tissue sarcomas during pregnancy: A narrative review of the literature

“…Most cases were treated during pregnancy with chemotherapy, radiotherapy to the extremity and/or surgery and resulted in a favorable outcome for both mother and newborn. Only two patients underwent termination of pregnancy [10] , [13] , [14] , [15] , [16] , [17] , [18] .…”

Ewing's sarcoma of the cervix: A case report of an unusual diagnosis in pregnancy treated with surgery, adjuvant VIDE and radiotherapy

“…Our patient was pregnant and her diagnosis was an incidental finding during her scheduled routine prenatal ultrasound. In the current literature, that extraosseus Ewing sarcoma diagnosis during pregnancy has been reported in 6 cases (13,20). Only 5 of these cases received chemotherapy during pregnancy.…”

“…The coexistence of pregnancy makes the therapeutic strategy challenging. Only 6 cases with extraosseous Ewing sarcomas during pregnancy have been reported (13,20).…”

A Rare Case of Ewing’s Sarcoma in Pregnancy

“…Bone and soft tissue sarcomas, being generally rare diseases, present more infrequently during gestation. 3…”