Bone and soft tissue sarcomas during pregnancy: A narrative review of the literature

Zarkavelis, George; Petrakis, Dimitrios; Fotopoulos, George; Mitrou, Sotirios; Pavlidis, Nicholas

doi:10.1016/j.jare.2016.01.003

Cited by 20 publications

(27 citation statements)

References 69 publications

(77 reference statements)

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“…The recommended treatment for synovial sarcoma is surgery followed by radiotherapy; chemotherapy is reserved for patients with advanced or metastatic disease,15 although experts still debate the role of chemotherapy in preventing metastases and improving survival. Indeed, the management plan for all 12 patients involved surgical resection of the tumour, however the choice of additional therapy was not as consistent.…”

Section: Discussionmentioning

confidence: 99%

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Synovial sarcoma in an HIV-positive pregnant woman and review of literature

Akhanoba

Zill‐E‐Huma²,

Pollock

et al. 2019

BMJ Case Rep

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We present a first case of synovial sarcoma in an HIV-positive pregnant woman. This 28-year-old woman was diagnosed with synovial sarcoma, a high-grade malignant soft tissue sarcoma, involving her left thigh during the first trimester of her pregnancy. She underwent surgical treatment in the form of hip disarticulation at 30 weeks’ gestation. She was subsequently delivered by emergency caesarean section (CS) at 34 weeks’ gestation when she presented with wound sepsis and a scan revealed static growth in a small for gestational age fetus. Prompt diagnosis and treatment of this aggressive tumour is important and should involve a multidisciplinary approach, with a balanced consideration of the maternal and fetal outcomes.

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Section: Discussionmentioning

confidence: 99%

“…There can be involvement of the skin, mouth, gastrointestinal and respiratory tract. Since 1971, there has been 14 reported cases of Kaposi’s sarcoma in pregnancy in both seropositive and seronegative patients 15 17–19…”

Section: Discussionmentioning

confidence: 99%

Synovial sarcoma in an HIV-positive pregnant woman and review of literature

Akhanoba

Zill‐E‐Huma²,

Pollock

et al. 2019

BMJ Case Rep

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“…Ewing's sarcoma is a member of tumor family including peripheral primitive neuroectodermal tumors and Askin tumors [1]. Primary lesion is most commonly localized in femur, pelvic bones, humerus, fibula, clavicula or tibia, localization in rib, scapula and vertebrae is very rare.…”

Section: Discussionmentioning

confidence: 99%

“…The rib localization has better prognosis. Initial findings are pain and tenderness by the growth of tumor [1,2].…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of coexistence of pregnancy and malignancy is approximately 1 in 1000-3000. Soft tissue sarcomas compose a very little portion of malignancies, and 137 cases were reported between the years of 1963-2016 and only 19 of these were Ewing's sarcoma (ES) [1]. ES is one of these tumors, which is very rare, and the most lethal of all [2].…”

Section: Introductionmentioning

confidence: 99%

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Rapidly growing chest wall tumor of a pregnant woman: ewingâs sarcoma

Özdil¹,

Kavurmacı²,

Akçam³

et al. 2018

Curr Thorac Surg

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The incidence of coexistence of pregnancy and malignancy is approximately 1 in 1000-3000. Soft tissue sarcomas compose a very little portion of malignancies and Ewing's sarcoma is one of these tumors, which is very rare, and the most lethal of all. We report a 37-year-old female at gestational age of 23 weeks with a rapidly growing tumor on the right chest wall and managed with chest wall resection and reconstruction. The togetherness of pregnancy and Ewing's sarcoma is a rare entity and there is no exact information for treatment in the literature except a few case reports.

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Pregnancy outcomes related to the treatment of sarcomas with anthracyclines and/or ifosfamide during pregnancy

et al. 2022

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Background Sarcomas are rare diagnoses but are seen with relative frequency in adolescents and young adults and thus can present in pregnancy. We sought to study the administration of anthracyclines and/or ifosfamide in pregnancy‐associated sarcomas. Patients and Methods We conducted a multi‐institutional retrospective study, identifying sarcoma patients who received anthracyclines and/or ifosfamide during pregnancy. Chart review identified variables related to demographics, cancer diagnosis, therapies, and outcome of the patient and fetus. Wilcoxon rank‐sum test compared two independent samples. Results We identified 13 patients at seven institutions with sarcoma who received anthracyclines and/or ifosfamide during pregnancy, including four bone sarcomas and nine soft tissue sarcomas diagnosed at a mean gestational age of 16.7 ± 5.9 weeks. Only nine patients had live births (9/13, 69.2%), with mean gestational age of 30.8 ± 3.8 weeks at delivery. The four patients with pregnancy loss all received both doxorubicin and ifosfamide, with chemotherapy initiated at 15.5 weeks as compared with 21.3 weeks for those patients with live births (p = 0.016). Conclusion In this multi‐institutional study of sarcoma chemotherapy regimens administered during pregnancy, we found a high rate of fetal demise that was seen only in patients receiving both doxorubicin and ifosfamide and statistically more likely with chemotherapy initiation earlier in the second trimester. While limited by a small sample size, our study represents the largest study of sarcoma patients that received anthracyclines and/or ifosfamide in pregnancy thus far reported and supports development of an international registry to study concerns raised by our study.

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Bone and soft tissue sarcomas during pregnancy: A narrative review of the literature

Abstract: Graphical abstract

Cited by 20 publications

References 69 publications

Synovial sarcoma in an HIV-positive pregnant woman and review of literature

Synovial sarcoma in an HIV-positive pregnant woman and review of literature

Rapidly growing chest wall tumor of a pregnant woman: ewingâs sarcoma

Pregnancy outcomes related to the treatment of sarcomas with anthracyclines and/or ifosfamide during pregnancy

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Bone and soft tissue sarcomas during pregnancy: A narrative review of the literature

Abstract: Graphical abstract

Cited by 20 publications

References 69 publications

Synovial sarcoma in an HIV-positive pregnant woman and review of literature

Synovial sarcoma in an HIV-positive pregnant woman and review of literature

Rapidly growing chest wall tumor of a pregnant woman: ewingâs sarcoma

Pregnancy outcomes related to the treatment of sarcomas with anthracyclines and/or ifosfamide during pregnancy

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Product

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Rapidly growing chest wall tumor of a pregnant woman: ewingâs sarcoma