Sarcoidosis Responding to Allopurinol

Cutaneous sarcoidosis

“…The role of mycophenolate mofetil remains to be established. Surgery may be of value in selected patients 2,15 , 23–27 . Well‐designed clinical trials are needed.…”

Generalized Ulcerative Sarcoidosis

“…Other treatment modalities have been described, including methotrexate,15 azathioprine, peripheral vasodilators,4 and, recently, allopurinol. 16 Although daily corticosteroid therapy given for systemic effect alone has also been reported as being beneficial,5 we chose this regimen empirically and were pleased with its results. We included the antimalarial hydroxychloroquine because of its anti-inflammatory and immunosuppressive properties, hoping that it would be steroid sparing and might suppress lymphocyte transformation.17 The latter could be a critical treatment mechanism, since sarcoidosis may be a disease characterized by activated T lympho¬…”

Orofacial granulomatosis and related conditions

“…Localized or systemic lesigns may undergo spontaneous remission in the early stages of the disease and treatment is sometimes reserved for advanced cases. Systemic lesions have responded favorably to systemic corticosteroids or allopurinol although the mortality rate for advanced disease remains approximately 5% (81,96).…”