Generalized Ulcerative Sarcoidosis

Schwartz, Robert A.

doi:10.1001/archderm.1982.01650230059030

Cited by 19 publications

(6 citation statements)

References 11 publications

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“…The patients with ulcerative sarcoidosis in our study had lesions with an atrophic base which resembled necrobiosis lipoidica. They were located in the pretibial area, consistent with previously published observations 13 . The atrophic nature and the location of these lesions implicate trauma as a possible etiology of the ulceration 11,12 ,14 …”

Section: Discussionsupporting

confidence: 90%

Clinicopathologic features of ulcerative‐atrophic sarcoidosis

et al. 2004

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Section: Discussionsupporting

confidence: 90%

Clinicopathologic features of ulcerative‐atrophic sarcoidosis

et al. 2004

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“…4,14,15,18,22,,,–26 It is also theorized that ulceration may be related to trauma, exposure to cold, or venous insufficiency, explaining the common lower leg involvement. 19,24,27,–29…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis Can Present with Necrotizing Granulomas Histologically: Two Cases of Ulcerated Sarcoidosis and Review of the Literature

et al. 2013

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Background: Sarcoidosis is a systemic inflammatory disorder with cutaneous involvement present in 25% of cases. The presence of naked granulomas histologically is the hallmark of sarcoidosis. The presence of necrotizing granulomas is highly suggestive of other granulomatous conditions and leads the clinician to pursue other diagnoses, such as infectious causes.Objectives: We describe two cases of sarcoidosis in which necrotizing granulomas were present on biopsy. Both patients had ulcerated cutaneous lesions of sarcoidosis. In one case, the presence of these atypical histologic features led to a delay in diagnosis of almost 10 years. We review the various histopathologic findings associated with cutaneous sarcoidosis and discuss a potential connection between ulcerated sarcoidosis and atypical histologic findings.Conclusion: When atypical histopathologic features are present, the differential diagnosis of sarcoidosis should not be excluded.Contexte: La sarcoïdose est une affection inflammatoire gé né rale, accompagné e de lé sions cutané es dans 25% des cas. La pré sence, sur le plan histologique, de granulomes «nus» est le signe d'appel de la sarcoïdose. La pré sence de granulomes né crosants est fortement é vocatrice d'autres affections granulomateuses et incite les cliniciens à approfondir la recherche d'autres diagnostics possibles, tels que des infections.Objectifs: Seront dé crits ici deux cas de sarcoïdose, dans lesquels il y avait pré sence de granulomes né crosants à la biopsie. Les deux patients pré sentaient des lé sions cutané es ulcé ré es de sarcoïdose. Dans l'un des cas, la pré sence de ces aspects histologiques atypiques a mê me retardé de presque 10 ans la pose du diagnostic. Les diffé rents ré sultats de l'examen histopathologique, associé s à la sarcoïdose cutané e seront passé s en revue, et il sera question d'un lien possible entre la sarcoïdose ulcé rative et des aspects histologiques atypiques.Conclusion: Il ne faudrait pas é carter le diagnostic diffé rentiel de sarcoïdose devant la pré sence d'aspects histologiques atypiques.

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“…Ulcerative lesions occur rarely, most frequently affecting women and blacks. The lesions usually are small (1–2 cm), involve the legs, and frequently resolve with systemic corticosteroid therapy 1–3 . Surgical treatment of ulcerative sarcoidosis has been reported only twice previously 2,4 .…”

Section: Introductionmentioning

confidence: 99%