Orofacial granulomatosis and related conditions

Rees, Terry D.

doi:10.1111/j.1600-0757.1999.tb00173.x

Cited by 24 publications

(24 citation statements)

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“…In our case, pathology showed edema, non-caseating epithelioid granuloma and multinucleated giant cells. These granulomas are histologically similar to those found in Crohn's disease and sarcoidosis (8). To diagnose the patient with orofacial granulomatosis, hematologic and biochemical examinations to assess the possibility of malabsorption should be performed, and the serum angiotensin converting enzyme level should be estimated.…”

Section: Discussionmentioning

confidence: 99%

“…Other features described included mucosal tags, cervical lymphadenopathy, lingual burning or swelling, disturbance in taste sensation, and gingival bleeding. Patients with Crohn's disease, sarcoidosis, or mycobacterial infection may present with similar orofacial manifestations (8,(12)(13)(14)(15)(16)(17). Among them, the association of orofacial granulomatosis with Crohn's disease is well documented, and rates of 10 to 48% have been reported in various series (12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

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Orofacial Granulomatosis: Report of a case.

et al. 2002

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Orofacial Granulomatosis: Report of a case.

et al. 2002

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“…Atopy has been found in 12-60% of the patients, and specific intolerance to foods or additives has been proposed (1,8). Potential allergic factors should be evaluated early in the diagnostic process by querying any history of contact allergies, patch testing and elimination diets, particularly for oral hygiene products such as toothpaste and mouthrinses, foods, food additives, flavorings, metals and cosmetics (9).…”

Section: Discussionmentioning

confidence: 99%

Granulomatous glossitis: a case report

Şentürk¹,

Aydın²,

Yıldız

et al. 2004

J Oral Sci

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IntroductionThe term orofacial granulomatosis was introduced to encompass the broad spectrum of non-necrotizing granulomatous inflammation in the oral and facial region, including patients with the complete triad of MelkerssonRosenthal syndrome (MRS), chelitis granulomatosa, sarcoidosis, Crohn's disease and infectious disorders such as tuberculosis (1,2). There may be several underlying etiologic mechanisms, with similar clinical and pathologic presentations, often manifesting at different points in time (3).Granulomatous glossitis was first described as a peculiar manifestation of MRS by Schuermann in 1952 (4). The typical triad of MRS is rarely seen simultaneously, and involvement of the tongue as a sole manifestation of MRS is much rarer. In monosymptomatic cases, making a clear diagnosis is difficult, and therefore a complete differential diagnosis for the other recurrent or persistent disorders characterized by macroglossia has to be done (5).Herein we report a case of granulomatous glossitis with no associated systemic disorder that was unresponsive to clofazimine and metronidazole, yet showed minor improvement with tetracycline. Case ReportA 50-year-old man presented with a complaint of enlargement of the tongue associated with small glossal tags. The papules had developed at the edge of the tongue and gradually increased in number during the previous five years. The patient complained of speech impairment, hypersalivation and a burning sensation on eating. He denied swelling of the lips, buccal and labial mucosa, and the face. His medical history was unremarkable except for hypertension that had been controlled with anti-hypertensive drug therapy for the previous 10 years.Dermatologic examination revealed slight enlargement of the tongue with a deep central furrow, multiple shallow radial fissures and multiple white mucosal tags at the edge of the tongue (Figs. 1 and 2).Laboratory investigations including a complete blood count, erythrocyte sedimentation rate, serum electrolytes, hepatic and renal function tests, serum iron level, anti-HIV antibodies, angiotensin converting enzyme level, thyroid function tests, IgG, IgA, IgM, IgE levels, ANA, anti-DNA, 24 hours urine calcium level, and stool examination for the presence of blood were all either negative or within normal limits.

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“…However, advanced diagnosis using immunological techniques indicates that most cases of DG are caused by mucocutaneous diseases, the most common ones being lichen planus (LP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV) (Endo et al, 2008a;Leao et al, 2008;Lo Russo et al, 2008;Lo Russo et al, 2009;Nisengard & Rogers, 1987;Yih et al, 1998). Contact allergic reactions to various oral hygiene products have also been reported to present as DG Endo et al, 2010;Lamey et al, 1990;Rees, 1998Rees, , 1999. Although a definitive diagnosis of the specific disease or disorder causing DG is required to provide proper treatment, it is almost impossible to do so based solely on clinical manifestations.…”

Section: Introductionmentioning

confidence: 99%

“…Localized or generalized epithelial desquamation, erythema, ulceration, and/or vesiculobullous lesions of the gingiva is sometimes elicited by contact hypersensitivity reactions to various foodstuffs, preservatives, oral hygiene products and dental restorative materials Endo et al, 2010;Lamey et al, 1990;Rees, 1998Rees, , 1999 ( Figs. 7 and 8).…”

Section: Hypersensitivity Reactions As Cause Of Dgmentioning

confidence: 99%