Sapovirus in Adults in Rehabilitation Center, Upper Austria

Mikula, Claudia; Springer, Burkhard; Reichart, Sandra; Bierbacher, Katharina; Lichtenschopf, Alfred; Hoehne, Marina

doi:10.3201/eid1607.091789

Cited by 11 publications

(7 citation statements)

References 9 publications

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“…We also found that adults had symptomatic sapovirus infections. Adults have been found to have sapovirus infections in other studies [12], [73], [74]. The occurrence of human infecting sapoviruses among the patient cases together with the detection of human-specific genetic marker HF183, adenoviruses and noroviruses from the contaminated drinking water suggests that human faecal material was present at the pipe breakage site.…”

Section: Discussionmentioning

confidence: 86%

Novel Microbiological and Spatial Statistical Methods to Improve Strength of Epidemiological Evidence in a Community-Wide Waterborne Outbreak

Jalava

Rintala²,

Ollgren

et al. 2014

PLoS ONE

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Failures in the drinking water distribution system cause gastrointestinal outbreaks with multiple pathogens. A water distribution pipe breakage caused a community-wide waterborne outbreak in Vuorela, Finland, July 2012. We investigated this outbreak with advanced epidemiological and microbiological methods. A total of 473/2931 inhabitants (16%) responded to a web-based questionnaire. Water and patient samples were subjected to analysis of multiple microbial targets, molecular typing and microbial community analysis. Spatial analysis on the water distribution network was done and we applied a spatial logistic regression model. The course of the illness was mild. Drinking untreated tap water from the defined outbreak area was significantly associated with illness (RR 5.6, 95% CI 1.9–16.4) increasing in a dose response manner. The closer a person lived to the water distribution breakage point, the higher the risk of becoming ill. Sapovirus, enterovirus, single Campylobacter jejuni and EHEC O157:H7 findings as well as virulence genes for EPEC, EAEC and EHEC pathogroups were detected by molecular or culture methods from the faecal samples of the patients. EPEC, EAEC and EHEC virulence genes and faecal indicator bacteria were also detected in water samples. Microbial community sequencing of contaminated tap water revealed abundance of Arcobacter species. The polyphasic approach improved the understanding of the source of the infections, and aided to define the extent and magnitude of this outbreak.

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Section: Discussionmentioning

confidence: 86%

Novel Microbiological and Spatial Statistical Methods to Improve Strength of Epidemiological Evidence in a Community-Wide Waterborne Outbreak

Jalava

Rintala²,

Ollgren

et al. 2014

PLoS ONE

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“…It also suggests stability of the genotype as older strains from 2003 shared high nucleotide identities over the partial capsid gene region to strains as recent as 2012 and 2013. Genogroup IV has been frequently reported in children as well as adults with gastroenteritis [4,10,32,33] and particularly in SaV-associated outbreaks [7,8,34,35]. The second most prevalent and widely-distributed genotype, GI.2, is also frequently reported in patients with gastroenteritis worldwide [6,8,10,30,31].…”

Section: Discussionmentioning

confidence: 99%

“…The virus is predominantly reported in outbreaks and sporadic cases of gastroenteritis in children [2][3][4][5][6], but has more recently been reported in adult populations [7][8][9][10]. Sapoviruses are small, non-enveloped, single-stranded RNA viruses.…”

Section: Introductionmentioning

confidence: 99%

Diverse sapovirus genotypes identified in children hospitalised with gastroenteritis in selected regions of South Africa

Murray

Nadan

Page³

et al. 2016

Journal of Clinical Virology

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“…5). All reported intergenogroup recombinant strains were GIV (based on VP1 sequence), whereas they were clustered together with GII strains in the RdRp region (46,85,102,116,117). Intragenogroup recombinant strains within GI (118)(119)(120), GII (84,121,122), and GIII (123) have been identified.…”

Section: Recombinant Strainsmentioning

confidence: 99%

Comprehensive Review of Human Sapoviruses

et al. 2015

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SUMMARY Sapoviruses cause acute gastroenteritis in humans and animals. They belong to the genus Sapovirus within the family Caliciviridae . They infect and cause disease in humans of all ages, in both sporadic cases and outbreaks. The clinical symptoms of sapovirus gastroenteritis are indistinguishable from those caused by noroviruses, so laboratory diagnosis is essential to identify the pathogen. Sapoviruses are highly diverse genetically and antigenically. Currently, reverse transcription-PCR (RT-PCR) assays are widely used for sapovirus detection from clinical specimens due to their high sensitivity and broad reactivity as well as the lack of sensitive assays for antigen detection or cell culture systems for the detection of infectious viruses. Sapoviruses were first discovered in 1976 by electron microscopy in diarrheic samples of humans. To date, sapoviruses have also been detected from several animals: pigs, mink, dogs, sea lions, and bats. In this review, we focus on genomic and antigenic features, molecular typing/classification, detection methods, and clinical and epidemiological profiles of human sapoviruses.

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Sapovirus in Adults in Rehabilitation Center, Upper Austria

Cited by 11 publications

References 9 publications

Novel Microbiological and Spatial Statistical Methods to Improve Strength of Epidemiological Evidence in a Community-Wide Waterborne Outbreak

Novel Microbiological and Spatial Statistical Methods to Improve Strength of Epidemiological Evidence in a Community-Wide Waterborne Outbreak

Diverse sapovirus genotypes identified in children hospitalised with gastroenteritis in selected regions of South Africa

Comprehensive Review of Human Sapoviruses

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