Samarangenin B from
            <i>Limonium sinense</i>
            Suppresses Herpes Simplex Virus Type 1 Replication in Vero Cells by Regulation of Viral Macromolecular Synthesis

Kuo, Yu Chi; Lin, Lie Chwen; Tsai, Wei‐Jern; Chou, Cheng‐Jen; Kung, Szu Hao; Ho, Yen Hui

doi:10.1128/aac.46.9.2854-2864.2002

Cited by 88 publications

(53 citation statements)

References 38 publications

(29 reference statements)

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“…35) Vero cells (3.5ϫ10 5 /dish) were overlaid with test compounds (100 mM) and 100 plaque forming units (PFU) of HSV-1 were added to each dish. The viruses were adsorbed for 1 h at 37°C and 1% methylcellulose was added to each well.…”

Section: Methodsmentioning

confidence: 99%

The Constituents and Their Bioactivities of Houttuynia cordata

Chou

et al. 2009

Chem. Pharm. Bull.

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Chemical investigation on the whole plant of Houttuynia cordata has resulted in the isolation of two new compounds, named as houttuynoside A (1) and houttuynamide A (2), together with thirty-eight known compounds. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. In the inhibitory effects on herpes simplex virus type 1 (HSV-1) assay, norcepharadione B (10) showed good inhibitory activity against the replication of HSV-1. In addition, the antioxidant and antityrosinase activities of some isolated compounds were also evaluated. Among these compounds, quercitrin (25)

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Section: Methodsmentioning

confidence: 99%

The Constituents and Their Bioactivities of Houttuynia cordata

Chou

et al. 2009

Chem. Pharm. Bull.

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“…The method followed procedures described previously [23]. Aliquots of 1 lg of RNA were reverse-transcribed with the Advantage TM RTfor-PCR kit from CLONTECH according to the manufacturer's instructions.…”

Section: Synthesis Of First Strand Cdnamentioning

confidence: 99%

“…However, ethnopharmacology provides scientists with an alternative approach for the discovery of antiviral agents. The polysaccharides [19], anthraquinones [20], triterpenes [21], phloroglucinol [22], flavonoids [23], and catechin derivatives [24] isolated from medicinal plants are found to have inhibitory activities against the replication of HSV-1. There has been a promising result of a naturally occurring antiherpetic agent, n-docosanol, which has recently completed extensive clinical evaluation and been approved by the US Food and Drug Administration as a topical treatment for herpes labialis [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Herpes simplex virus type 1 propagation in HeLa cells interrupted by Nelumbo nucifera

et al. 2005

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Inhibitory effects of ethanolic extracts from 10 Chinese herbs on herpes simplex virus type 1 (HSV-1) replication were investigated. By a bioassay-guided fractionation procedure, NN-B-5 was identified from seeds of N. nucifera. NN-B-5 significantly blocked HSV-1 multiplication in HeLa cells without apparent cytotoxicity. To elucidate the point in HSV-1 replication where arrest occurred, a set of key regulatory events leading to the viral multiplication was examined, including HSV-1 DNA synthesis and viral immediate early gene expressions. Data from polymerase chain reaction and Southern blotting showed that there were impairments of HSV-1 DNA replication in HeLa cells treated with NN-B-5. Results indicated that the production and mRNA transcription of infected cell protein (ICP) 0 and ICP4 were decreased in NN-B-5 treated HeLa cells. Results of an electrophoretic mobility shift assay demonstrated that NN-B-5 interrupted the formation of alpha-trans-induction factor/C1/Oct-1/GARAT multiprotein/DNA complexes. The mechanisms of antiviral action of NN-B-5 seem to be mediated, at least in part, through inhibition of immediate early transcripts, such as ICP0 and ICP4 mRNA and then blocking of all downstream viral products accumulation and progeny HSV-1 production.

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“…To firmly establish the antiviral activity and adverse reactions like reactogenecity or toxicity of the purified phytomolecules, appropriate in vivo studies (animal models) and subsequent clinical trials are necessary. A bioactive flavonoid 'Baicalein' isolated from Chinese medicinal plant Scutellaria baicalensis Georgi showed antiviral properties using high-speed counter-current chromatography (HSCCC) technique [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58].…”

Section: Antiviral Molecules Of Plant Originmentioning

confidence: 99%

Antiviral Phytochemicals: An Overview

Kapoor¹,

Sharma²,

Kanwar³

2017

Biochem Physiol

100

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The pandemic of viral diseases during recent years has forced the scientific community to investigate less toxic antiviral phytomolecules instead of using nucleic acid analogues, protease inhibitors or other toxic synthetic molecules as antiviral therapeutics. Plants and many of their secondary metabolites because of the healing properties have been in traditional use throughout the world since ancient times. They provide us diverse bioactive phytochemicals which play synergetic role in maintaining human health. The development of clinical products from phyto-pharmaceuticals is a trending approach to look for ecofriendly therapeutic molecules. More than 50% of drugs used in Western nations are derived from plants or their constituents. Many plants have significant antiviral properties too. Very little information is available about plants of antiviral significance. This article briefly reviews various phytochemicals/bioactive molecules which have been isolated from plants and possess antiviral constituents, their mode of action and potential applications in treating/preventing viral diseases.

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Samarangenin B from Limonium sinense Suppresses Herpes Simplex Virus Type 1 Replication in Vero Cells by Regulation of Viral Macromolecular Synthesis

Cited by 88 publications

References 38 publications

The Constituents and Their Bioactivities of Houttuynia cordata

The Constituents and Their Bioactivities of Houttuynia cordata

Herpes simplex virus type 1 propagation in HeLa cells interrupted by Nelumbo nucifera

Antiviral Phytochemicals: An Overview

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