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Abstract:The purpose of this study was to investigate the effect of green tea extract (GTE) supplementation combined with endurance training on endurance capacity and performance in sedentary men. Forty untrained men (age: 20 ± 1 years) participated in this study. Subjects were assigned to 1 of 4 treatments: (i) placebo-control (CTRL), (ii) GTE, (iii) endurance training (Ex), and (iv) endurance training with GTE (ExGTE). During the 4-week intervention, exercise training was prescribed as 75% oxygen uptake reserve for three 20-min sessions per week, and either GTE (250 mg/day) or placebo was provided. Endurance capacity, malondialdehyde (MDA), total antioxidant status (TAS), and creatine kinase (CK) were examined. Ex and ExGTE but not GTE improved exhaustive-run time (Ex: +8.2%, p = 0.031; ExGTE: +14.3%, p < 0.001); in addition, Ex and ExGTE significantly increased maximal oxygen uptake by ϳ14% (p = 0.041) and ϳ17% (p = 0.017) above the values of the CTRL group, respectively. Both Ex and ExGTE significantly decreased the increase of CK by ϳ11%-32% below that of CTRL following an exhaustive run (Ex: p = 0.007; ExGTE: p = 0.001). Moreover, TAS levels increased by ϳ11% in ExGTE after training (p = 0.040), and GTE, Ex, and ExGTE markedly attenuated exercise-induced MDA production (p = 0.01, p = 0.005, p = 0.011, respectively). In conclusion, this investigation demonstrated that daily ingestion of GTE during endurance training does not impair improvements in endurance capacity. Moreover, endurance training combined with GTE not only increases antioxidant capacity without attenuating endurance training adaptations, but also further attenuates acute exercise-induced CK release.Key words: V O 2max , malondialdehyde (MDA), creatine kinase (CK), oxidative stress, catechins.Résumé : Cette étude se propose d'examiner l'effet de la supplémentation en extrait de thé vert (« GTE ») combinée à l'entraînement en endurance sur la capacité d'endurance et la performance chez des hommes sédentaires. Quarante hommes non entraînés (âge de 20 ± 1 ans) participent à cette étude. Les sujets sont assignés à l'un des quatre traitements : (i) placebocontrôle (« CTRL »), (ii) GTE, (iii) entraînement en endurance (Ex) et (iv) entraînement en endurance plus GTE (ExGTE). Durant les quatre semaines de l'intervention, l'entraînement physique consiste en trois séances de 20 min à une intensité sollicitant 75 % du consommation d'oxygène de réserve dans la condition de GTE (250 mg/jour) ou de placebo. On évalue la capacité d'endurance, le taux de malonaldéhyde (« MDA »), le statut antioxydant total (« TAS ») et la créatine kinase (« CK »). Ex et ExGTE, mais pas GTE suscitent une amélioration du temps de course jusqu'à épuisement (Ex: +8,2 %, p = 0,031; ExGTE: +14,3 %, p < 0,001); de plus, Ex et ExGTE suscitent une augmentation significative du consommation maximale d'oxygène de ϳ14 % (p = 0,041) et de ϳ17 % (p = 0,017) respectivement par rapport au groupe CTRL. EX et ExGTE suscitent une baisse significative de l'augmentation de CK de ϳ11-32 % par rap...

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Three known flavones and seven known homoisoflavonoids were isolated from the methanolic extract of the leaves of Agave sisalana Perrine ex Engelm. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were also evaluated for immunopharmacological activity. PBMC were used as target cells, and cell proliferation was determined by 3H-thymidine uptake. (±)-3,9-Dihydroeucomin (4), dihydrobonducellin (5), and 5,7-dihydroxy-3-(4′-hydroxybenzyl)-4-chromanone (7) showed inhibitory effects on PBMC proliferation activated by PHA with IC50 values 19.4, 73.8, and 58.8 µM, respectively. All three compounds significantly inhibited the production of IL-2 and IFN-γ in activated PBMC in a concentration-dependent manner.

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Objective. To investigate the effect of muscle strength exercise training (MSET) on lean mass (LM) gain and muscle hypertrophy in older patients with lower extremity osteoarthritis (OA). Methods. A comprehensive search of online databases was performed on April 20, 2019. Randomized controlled trials (RCTs) that reported the effects of MSET on LM, muscle thickness, and cross-sectional area (CSA) in older patients with OA were identified. A risk of bias assessment and meta-analysis were performed for the included RCTs. Results. We included 19 RCTs with a median Physiotherapy Evidence Database score of 6 of 10 (range 3-7). In total, data from 1,195 patients (65% women, 85% with knee OA) with a mean age of 62.1 years (range 40-86 years) were analyzed. MSET resulted in significantly higher LM gain (standardized mean difference [SMD] 0.49 [95% confidence interval (95% CI) 0.28, 0.71], P < 0.00001) than did the nonexercise controls. Meta-analysis results revealed significantly positive effects of MSET on muscle thickness (SMD 0.82 [95% CI 0.20, 1.43], P = 0.009) and CSA (SMD 0.80 [95% CI 0.25, 1.35], P = 0.004) compared with nonexercise controls. No significant effects in favor of MSET were observed for any muscle outcome compared with exercise controls. Five RCTs reported nonsevere adverse events in response to MSET, whereas no RCTs reported severe events. Conclusion. MSET is effective in increasing LM and muscle size in older adults with OA. Clinicians should incorporate MSET into their management of patients at risk of low muscle mass to maximize health status, particularly for older individuals with OA.