The Constituents and Their Bioactivities of Houttuynia cordata

Chou, S C; Su, Chung Ren; Ku, Yuh Chi; Wu, Tian Shung

doi:10.1248/cpb.57.1227

Cited by 64 publications

(52 citation statements)

References 34 publications

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“…Amounts of 27.35 ± 0.35, 17.73 ± 0.40, 46.13 ± 0.26, and 77.69 ± 0.28 lg/kg of fresh weight were quantified for chlorogenic acid, caffeic acid, rutin, and quercitrin hydrate, respectively. Previous studies chemically identified bioactive components in HC extract such as quercitrin, isoquercitrin, rutin, hyperoside, chlorogenic acid, quercetin (Xu et al 2006;Chou et al 2009;Meng et al 2009;Jang et al 2011). Results from the current study showed a similar profile of bioactive components in HC extract to those from previous studies.…”

Section: Resultssupporting

confidence: 80%

Preventive responses to a standardized extract of Houttuynia cordata supplemented diet in obesity induced by a high-fat diet in mice

Park

Shim

2015

J Korean Soc Appl Biol Chem

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The current study investigated preventive responses to Houttuynia cordata (HC) standardized extract in obesity induced by a high-fat diet (HFD) in mice. Highperformance liquid chromatography was carried out to analyze bioactive components in HC. Mice were divided into HFD groups as a control and HFD groups fed with 1 and 4 % of HC supplementation diet. Changes of the body weight of mice, blood biological factors, and histopathological markers were measured. Bioactive components from HC were characterized to contain chlorogenic acid, caffeic acid, rutin, and quercitrin. HC supplementation reduced body weight, glucose, and total cholesterol levels, but it did not affect aspartic acid transaminase, alanine transaminase, or triglyceride amounts in plasma from mice induced by HFD. A 4 % HC supplementation showed a remarkable decrease in the number of large adipocyte in subcutaneous and abdominal adipose tissue. Histopathological evaluation of liver injury induced by HFD was observed to be improved by HC supplementation, leading to attenuated levels of cytoplasmic vacuolation of hepatocytes. From these results, we explored that standardized extract of HC could be a potential natural product to be directly associated with the control of weight.

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Section: Resultssupporting

confidence: 80%

Preventive responses to a standardized extract of Houttuynia cordata supplemented diet in obesity induced by a high-fat diet in mice

Park

Shim

2015

J Korean Soc Appl Biol Chem

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“…Some phenolic compounds in the extract of this plant have been described [15][16][17] , however, the phenolic acid composition in the commercialized fermentation products has not yet been determined. Preliminary separation and identification of individual phenolic compounds in water-soluble constituents of two commercialized fermentation products were conducted by reversed phase HPLC.…”

Section: Phenolic Acid Compositionmentioning

confidence: 99%

“…Four flavonoid compounds (rutin, hyperoside, quercitrin, and quercetin) were reported as major bioactive ingredients in H. cordata 15,16 . Two new compounds, houttuynoside A and houttuynamide A, and 38 known compounds have been also identified from a whole plant methanolic extract 17 . Nonetheless, phenolic acid composition of a plant fermentation product has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Phenolic acid composition and anticancer activity against human cancer cell lines of the commercially available fermentation products of Houttuynia cordata

Senawong¹,

Khaopha²,

Misuna³

et al. 2014

ScienceAsia

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A number of Houttuynia cordata fermentation products are commercially available in Thailand. However, their anticancer activity remains to be investigated. In this study, the phenolic acid composition and anticancer activity of two commercialized H. cordata fermentation products were investigated. Reversed phase HPLC was used to identify and quantify phenolic acids. MTT and Annexin V staining assays were used to investigate antiproliferative and apoptosis induction activities, respectively. Seven phenolic acids including protocatechuic, p-hydroxybenzoic, vanillic, syringic, p-coumaric, ferulic, and sinapinic acids were detected in the water-soluble constituents of both fermentation products 1 and 2. Water-soluble constituents of fermentation product 2 containing a greater phenolic acid content were more effective than product 1 in inhibiting the growth of HeLa, HCT116, and HT29 cells in a dose-and time-dependent manner. The non-cancer cell line Vero cells appeared to be resistant to both fermentation products. The growth inhibitory effects of both fermentation products in HeLa, HCT116, and HT29 cells included induction of apoptosis. These results suggest that commercially available fermentation products of H. cordata contain several anticancer phenolic acids that may be beneficial in the treatment of human cancer.

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“…Quercetin 3-O-methyl ether and ophioglonin obtained from plants belonging to Ophioglossaceae genus have shown slight activity against HBV [50]. Since 1995 when antiviral activities against enveloped viruses were discovered in extracts of Houttuynia cordata [51], such as influenza, HIV, herpes, SARS and also in enteroviruses [51][52][53][54], 40 compounds have been isolated from the whole plant [55].…”

Section: Resultsmentioning

confidence: 99%

“…Among all of them, norcepharadione B has been identified as anti-herpes virus type 1 compound [55], quercetin may reduce virions production of HCV [56], but not against HBV [7] and quercetin 3-rhamnoside may be effective against influenza A virus [57].…”

Section: Resultsmentioning

confidence: 99%

Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

et al. 2011

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Abstract:In an extensive screening, the antiviral, antitrypanosomal and anticancer properties of extracts from 82 plants used in traditional Chinese medicine and European phytomedicine were determined. Several promising plants that were highly effective against hepatitis B virus (HBV), bovine viral diarrhoea virus (BVDV)-a flavivirus used here as a surrogate in vitro model of hepatitis C virus, trypanosomes (Trypanosoma brucei brucei) and several cancer cell lines were identified. Six aqueous extracts from Celosia cristata, Ophioglossum vulgatum, Houttuynia cordata, Selaginella tamariscina, Alpinia galanga and Alpinia oxyphylla showed significant antiviral effects against BVDV without toxic effects on host embryonic bovine trachea (EBTr) cells, while Evodia lepta, Hedyotis Moreover, among fifteen water extracts that combined high antiproliferative activity (IC 50 0.5-20 µg/mL) and low acute in vitro toxicity (0-10% reduction in cell viability at IC 50 ), Coptis chinensis presented the best beneficial characteristics. In conclusion, traditional herbal medicine from Europe and China still has a potential for new therapeutic targets and therapeutic applications.

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The Constituents and Their Bioactivities of Houttuynia cordata

Cited by 64 publications

References 34 publications

Preventive responses to a standardized extract of Houttuynia cordata supplemented diet in obesity induced by a high-fat diet in mice

Preventive responses to a standardized extract of Houttuynia cordata supplemented diet in obesity induced by a high-fat diet in mice

Phenolic acid composition and anticancer activity against human cancer cell lines of the commercially available fermentation products of Houttuynia cordata

Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

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