Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

Herrmann, Florian; Romero, Marta R.; Blazquez, Alba G.; Kaufmann, Dorothea; Ashour, Mohamed L.; Kahl, Stefan; Marin, José J.G.; Efferth, Thomas

doi:10.3390/d3040547

Cited by 43 publications

(29 citation statements)

References 91 publications

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“…b . brucei line was obtained from Prof. Peter Overath (Max‐Planck‐Institut für Biologie, Tübingen, Germany) and has been cultured in our department of IPMB since 1999 . Trypanosoma brucei brucei was maintained in complete Baltz medium .…”

Section: Methodsmentioning

confidence: 99%

Chemical Profiling of the Essential Oils of Syzygium aqueum, Syzygium samarangense and Eugenia uniflora and Their Discrimination Using Chemometric Analysis

Sobeh

Braun

Krstin

et al. 2016

Chemistry & Biodiversity

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The essential oil compositions of the leaves of three related Myrtaceae species, namely Syzygium aqueum, Syzygium samarangense and Eugenia uniflora, were investigated using GLC/MS and GLC/FID. Altogether, 125 compounds were identified: α-Selinene (13.85%), β-caryophyllene (12.72%) and β-selinene constitute the most abundant constituents in S. aqueum. Germacrene D (21.62%) represents the major compound in S. samarangense whereas in E. uniflora, spathulenol (15.80%) represents the predominant component. Multivariate chemometric analyses were used to discriminate the essential oils using hierarchical cluster analysis (HCA) and principal component analysis (PCA) based on the chromatographic results. The antimicrobial activity of the popularly used E. uniflora essential oil was assessed using broth microdilution method against six Gram-positive, three Gram-negative bacteria and two fungi. The oil showed moderate antimicrobial activity against Bacillus licheniformis exhibiting MIC and MMC of 0.63 mg/ml. The cytotoxic activity of E. uniflora essential oil was investigated against Trypanosoma brucei brucei (T. b. brucei) and MCF-7 cancer cell line using MTT assay. It showed moderate activity against MCF-7 cells with an IC value of 76.40 μg/ml. On the other hand, T. brucei was highly susceptible to E. uniflora essential oil with IC of 11.20 μg/ml, and a selectivity index of 6.82.

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Section: Methodsmentioning

confidence: 99%

Chemical Profiling of the Essential Oils of Syzygium aqueum, Syzygium samarangense and Eugenia uniflora and Their Discrimination Using Chemometric Analysis

Sobeh

Braun

Krstin

et al. 2016

Chemistry & Biodiversity

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“…Artemisia is a diverse genus of plants with 400 species belonging to the family Asteraceae, with most herbs having strong aromas and bitter tastes arising from the presence of terpenoids and sesquiterpene lactones (Herrmann et al, 2011). The representative species of the Artemisia are Artemisia annua Linne and Artemisia capillaris Thunberg.…”

Section: Introductionmentioning

confidence: 99%

Artemisia capillaris extract protects against bile duct ligation-induced liver fibrosis in rats

Han

Kim

Choi

et al. 2013

Experimental and Toxicologic Pathology

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“…In this regard, Arctium lappa (Asteraceae), also known as burdock, is a medicinal plant popularly used as hepatoprotective, antiseptic and anti-inflammatory that has provided biologically activity compounds, mainly lignans, against some parasites, such as Trypanosoma cruzi [13]. Furthermore, it was shown that the fruits extract of A. lappa improved kidney function in mice infected with S. haematobium [14].…”

Section: Introductionmentioning

confidence: 99%

In vivo and In vitro of Arctiin Schistosomicidal Activity

LC¹,

MM²,

PM³

et al. 2017

Clin Exp Pharmacol

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Human schistosomiasis, caused by trematode worms of the genus Schistosoma, is one of the most significant neglected tropical diseases, affecting more 200 million individuals worldwide and praziquantel is the only available drug to treat this neglected disease. Arctiin is a lignan obtained from Arctium lappa (Asteraceae) with antiinflammatory and antiproliferative activities. Our purpose was to investigate the in vitro and in vivo schistosomicidal activities of arctiin in mice infected with S. mansoni. Arctiin (200 and 100 μM) caused mortality, tegumental alterations, and reduction of motor activity of adult worms of S. mansoni in culture. Oral administration of a single dose of arctiin (25 mg/kg) on day 45 of infection did not reduce worm burden or cause any alteration in the analyzed parameters when compared to infected untreated mice. On the other hand, intraperitoneal treatment with arctiin (50 mg/kg) was able to reduce the hepatic granuloma volume by 20% in comparison to infected untreated mice. In addition, after intraperitoneal administration of arctiin in mice it was shown by HPLC analysis that arctiin was present in murine plasma. More studies should be conducted to verify the possible mechanism of action on inflammatory components present in granuloma formation.

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Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

Cited by 43 publications

References 91 publications

Chemical Profiling of the Essential Oils of Syzygium aqueum, Syzygium samarangense and Eugenia uniflora and Their Discrimination Using Chemometric Analysis

Chemical Profiling of the Essential Oils of Syzygium aqueum, Syzygium samarangense and Eugenia uniflora and Their Discrimination Using Chemometric Analysis

Artemisia capillaris extract protects against bile duct ligation-induced liver fibrosis in rats

In vivo and In vitro of Arctiin Schistosomicidal Activity

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